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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
PAFAH1B3 Is a KLF9 Target Gene that Promotes Proliferation and Metastasis in Pancreatic Cancer
[Scientific Reports] Researchers found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) was highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells, while downregulation of PAFAH1B3 inhibited these processes.
The Clinical Significance and Oncogenic Function of LRRFIP1 in Pancreatic Cancer
[Discover Oncology] Investigators explored the roles and mechanisms of leucine rich repeat of flightless-1 interacting protein 1 (LRRFIP1) in pancreatic cancer. The influences of LRRFIP1 on the proliferation and migration of pancreatic cancer cells were assessed in vitro.
MIF/NR3C2 Axis Regulates Glucose Metabolism Reprogramming in Pancreatic Cancer Through MAPK-ERK and AP-1 Pathways Get Access Arrow
[Carcinogenesis] Scientists provided evidence that migration inhibitory factor (MIF) and nuclear receptor subfamily 3 group C member 2 (NR3C2) interactively regulated metabolic reprogramming, resulting in MIF-induced cancer growth and progression in PDAC.
Codetection of Proteins and RNAs on Extracellular Vesicles for Pancreatic Cancer Early Diagnosis
[Analytical Chemistry] Investigators analyzed the coexpressions of three protein markers and three RNA markers on extracellular vesicles from three pancreatic cell lines and 30 human plasma samples using codetection platform of proteins and RNAs.
Effects of Hypertriglyceridemia with or Without NEFA Elevation on β-Cell Function and Insulin Clearance and Sensitivity
[Journal Of Clinical Endocrinology & Metabolism] Researchers compared the glucometabolic effects of acute hypertriglyceridemia alone or combined with non-esterified fatty acids (NEFA) elevation in non-diabetic subjects.
Mechanisms of Spinophilin-Dependent Pancreas Dysregulation in Obesity
[American Journal of Physiology - Endocrinology and Metabolism] Scientists provided the first evidence that pancreatic spinophilin protein interactions were modulated by obesity and that loss of spinophilin specifically in pancreatic beta cells impacted whole-body glucose tolerance.
Quantitative MR Imaging Biomarkers for Distinguishing Inflammatory Pancreatic Mass and Pancreatic Cancer-A Systematic Review and Meta-Analysis
[European Radiology] The authors evaluated the diagnostic performance of quantitative magnetic resonance (MR) imaging biomarkers in distinguishing between inflammatory pancreatic masses and pancreatic cancer
Roche and VinCense to Augment Access to Diabetes Care in Tamil Nadu
[Express Healthcare] Roche has signed a Memorandum of Understanding with VinCense. Under the terms of the agreement, the two companies aim to implement 3 programs in Madurai district of Tamil Nadu state, screening 100,000 individuals over the next two years for diabetes and intervention for uncontrolled diabetes mellitus management and tuberculosis–diabetes mellitus co-morbidity management.
PAFAH1B3 Is a KLF9 Target Gene That Promotes Proliferation and Metastasis in Pancreatic Cancer
[Scientific Reports] Researchers found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) was highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells, while downregulation of PAFAH1B3 inhibited these processes.
Hepatic Signal Transducer and Activator of Transcription-3 signaling Drives Early-Stage Pancreatic Cancer Cachexia via Suppressed Ketogenesis
[Journal Of Cachexia Sarcopenia And Muscle] Researchers establishes a direct link between skeletal muscle homeostasis and hepatic metabolism. Dietary and anti-inflammatory interventions that restored ketogenesis may be a viable preventative approach for pre-cachectic patients with pancreatic cancer.
Infection with SARS-CoV-2 Can Cause Pancreatic Impairment
[Signal Transduction And Targeted Therapy] Scientists analyzed pancreatic lesions in autopsy tissues from SARS-CoV-2 infected non-human primates (NHPs) models and vaccinated and infected NHPs from 2020 to 2023.
A 3D Atlas of the Human Developing Pancreas to Explore Progenitor Proliferation and Differentiation
[Diabetologia] Scientists mapped the spatial and chronological dynamics of human pancreatic cell differentiation and proliferation by using 3D imaging of cleared human embryonic and fetal pancreases.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
