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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
[Cancer Research] To provide insights into the molecular mechanisms regulating IL1A expression in PDAC, researchers performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression.
From Stem Cells to Pancreatic β-Cells: Strategies, Applications, and Potential Treatments for Diabetes
[Molecular And Cellular Biochemistry] Scientists introduce the development of functional β-cells and their heterogeneity and then turn to highlight recent advances in the generation of β-cells from stem cells and their potential applications in disease modeling, drug discovery and clinical therapy.
FGF7 Enhances the Expression of ACE2 in Human Islet Organoids Aggravating SARS-CoV-2 Infection
[Signal Transduction And Targeted Therapy] Researchers utilized islet organoids derived from human embryonic stem cells, animal models, and COVID-19 patients to discover that fibroblast growth factor 7 (FGF7) enhanced ACE2 expression within the islets, facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion.
Establishment, Characterization, and Biobanking of 36 Pancreatic Cancer Organoids: Prediction of Metastasis in Resectable Pancreatic Cancer
[Cellular Oncology] Researchers demonstrated the molecular architecture of borderline resectable pancreatic ductal adenocarcinoma (PDAC) manifests cancer dissemination of PDAC. 36 organoids isolated from primary tumor masses of PDAC patients with diverse metastatic statues were presented.
Dopamine Signalling in Pancreatic Islet Cells and Role in Adaptations to Metabolic Stress
[Journal Of Pharmacy And Pharmacology] Scientists evaluated islet cell signalling pathways and biological effects of dopamine, as well as alterations of islet dopamine in rodent models of diabetes of different aetiology.
A Pancreatic Cancer Organoid-in-Matrix Platform Shows Distinct Sensitivities to T Cell Killing
[Scientific Reports] Investigators described an INTERaction with Organoid-in-MatriX model system, that presentd a 3D co-culture-based platform for investigating matrix-dependent cellular crosstalk. They describe its potential to uncover new molecular mechanisms of T cell responses to murine KPC pancreatic ductal adenocarcinoma (PDAC) cells as well as PDAC patient-derived organoids.
QDPR Deficiency Drives Immune Suppression in Pancreatic Cancer
[Cell Metabolism] Scientists demonstrated that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, caused metabolite dihydrobiopterin (BH2) accumulation and decrease the ratio of tetrahydrobiopterin to BH2 in pancreatic ductal adenocarcinomas.
PAFAH1B3 Is a KLF9 Target Gene that Promotes Proliferation and Metastasis in Pancreatic Cancer
[Scientific Reports] Researchers found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) was highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells, while downregulation of PAFAH1B3 inhibited these processes.
The Clinical Significance and Oncogenic Function of LRRFIP1 in Pancreatic Cancer
[Discover Oncology] Investigators explored the roles and mechanisms of leucine rich repeat of flightless-1 interacting protein 1 (LRRFIP1) in pancreatic cancer. The influences of LRRFIP1 on the proliferation and migration of pancreatic cancer cells were assessed in vitro.
MIF/NR3C2 Axis Regulates Glucose Metabolism Reprogramming in Pancreatic Cancer Through MAPK-ERK and AP-1 Pathways Get Access Arrow
[Carcinogenesis] Scientists provided evidence that migration inhibitory factor (MIF) and nuclear receptor subfamily 3 group C member 2 (NR3C2) interactively regulated metabolic reprogramming, resulting in MIF-induced cancer growth and progression in PDAC.
Codetection of Proteins and RNAs on Extracellular Vesicles for Pancreatic Cancer Early Diagnosis
[Analytical Chemistry] Investigators analyzed the coexpressions of three protein markers and three RNA markers on extracellular vesicles from three pancreatic cell lines and 30 human plasma samples using codetection platform of proteins and RNAs.
Effects of Hypertriglyceridemia with or Without NEFA Elevation on β-Cell Function and Insulin Clearance and Sensitivity
[Journal Of Clinical Endocrinology & Metabolism] Researchers compared the glucometabolic effects of acute hypertriglyceridemia alone or combined with non-esterified fatty acids (NEFA) elevation in non-diabetic subjects.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
