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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Recruitment Milestone Reached in Diamyd® Phase III Trial
[Diamyd Medical] Diamyd Medical’s precision medicine Phase III trial for Type 1 Diabetes, DIAGNODE-3, has enrolled 100 patients. To date, no serious adverse events have been reported, and no patients have discontinued the trial.
Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
[Cancer Research] Investigators performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression. Both genetic and pharmacologic inhibition of p38 MAPK significantly diminished IL1α production in vitro.
Investigational mRNA Vaccine Induced Persistent Immune Response in Phase 1 Trial of Patients With Pancreatic Cancer
[Memorial Sloan Kettering Cancer Center] New results from a Phase I clinical trial showed that an mRNA-based therapeutic cancer vaccine candidate activated immune cells that persisted in the body up to three years after treatment in certain patients. In addition, a vaccine-induced immune response correlated with reduced risk of the cancer coming back.
Identification and Removal of Unexpected Proliferative Off-Target Cells Emerging after iPSC-Derived Pancreatic Islet Cell Implantation
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that the implantation of seven-stage induced PSC-derived pancreatic islet cells led to the emergence of unexpected off-target cells with proliferative capacity via in vivo maturation.
Efficient Vascular and Neural Engraftment of Stem Cell-Derived Islets
[Diabetes] The authors investigated the engraftment capability of pluripotent stem cell-derived islets (SC-islets) at three months post-transplantation, and observed that the cell apoptosis rates were lower, but the vascular density was similar in SC-islets to that of human pancreatic islets.
Exploiting Pancreatic Cancer Metabolism: Challenges and Opportunities
[Trends In Molecular Medicine] Scientists review the impact of metabolic changes on the interplay among stromal, immune, and pancreatic tumor cells, as glutamine and branched-chain amino acids emerge as pivotal players in modulating immune cell functions and tumor growth.
Nardilysin-Regulated Scission Mechanism Activates Polo-Like Kinase 3 to Suppress the Development of Pancreatic Cancer
[Nature Communications] Researchers found that development of apoptotic resistance and metastasis of KrasG12D-driven PDAC in mice was accelerated by deleting polo-like kinase 3 (Plk3).
Examination of Wnt Signaling as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma (PDAC) Using a Pancreatic Tumor Organoid Library (PTOL)
[PLOS One] Scientists constructed patient-derived organoids derived from pancreatic tumor organoid libraries. Each pancreatic organoid demonstrated varied niche factor dependencies, providing an avenue for targeted therapy, supported through growth analysis following combinatory treatment of Wnt inhibitor and standard chemotherapy in vitro.
CDK4/6 Inhibition Sensitizes MEK Inhibition by Inhibiting Cell Cycle and Proliferation in Pancreatic Ductal Adenocarcinoma
[Scientific Reports] Scientists explored the effects of Trametinib on pancreatic cancer and addressed the underlying mechanism of resistance as well as its reversal strategies.
Tumor-Selective Activity of RAS-GTP Inhibition in Pancreatic Cancer
[Nature] Scientists assessed the therapeutic potential of a RAS(ON) multi-selective inhibitor in a comprehensive range of PDAC models.
Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
[Cancer Research] Scientists utilized a convergence approach to identify tumor cell and cancer associated fibroblast interactions through the integration of single-cell data from human tumors with human organoid co-culture experiments.
Understanding, Diagnosing, and Treating Pancreatic Cancer from the Perspective of Telomeres and Telomerase
[Cancer Gene Therapy] The authors review the role of telomeres and telomerase as biomarkers in the development of pancreatic cancer and the progress of research on telomeres and telomerase as targets for therapeutic intervention.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
