Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?|
Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. The authors discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data. [Trends Endocrinol Met] Abstract
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Intarcia Announces Successful Cardiovascular Safety Results in Phase III FREEDOM-CVO Trial for ITCA 650, an Investigational Therapy for Type 2 Diabetes|
Intarcia Therapeutics, Inc. announced top-line results from its more than 4,000 patient Cardiovascular Safety Study (FREEDOM-CVO trial), clearing the last major clinical hurdle in the global FREEDOM Phase III Clinical Trial Program that started in early 2013. [Intarcia Therapeutics, Inc.] Press Release
Dance Biopharm’s China Licensee, Harmony Biopharm, Enters into New Joint Venture with Tonghua Dongbao Pharmaceutical, a Leading China Insulin Producer
Dance Biopharm Inc. announced that Harmony Biopharm Limited, Dance’s licensee for Dance 501 in Asia, has recently formed a joint venture with Tonghua Dongbao Pharmaceutical Co. and Shanghai Dongbao Biological Pharmaceutical Co. The joint venture will focus on obtaining regulatory approval in China and, if approval is obtained, preparing for commercialization of Dance 501. [Dance Biopharm Inc. (PR Newswire Association LLC.)] Press Release
NewLink Genetics Announces Results from Phase III IMPRESS Trial of Algenpantucel-L for Patients with Resected Pancreatic Cancer
NewLink Genetics Corporation announced results of its Phase III clinical trial for algenpantucel-L for patients with resected pancreatic cancer. The IMPRESS Phase III study of algenpantucel-L for patients with resected pancreatic cancer did not achieve its primary endpoint. [NewLink Genetics Corporation] Press Release
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