Volume 6.20 | May 26

Pancreatic Cell News 6.20 May 26, 2015
Pancreatic Cell News
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Researchers Discover Tumor Molecule that Causes Spread of Pancreatic Cancer
Researchers report a single molecule that switches on metastasis in pancreas cancers. They predict that testing for this molecule, called RUNX3, could soon help oncologists choose the most appropriate treatments based on the metastatic potential of each patient’s disease. [Press release from Fred Hutchinson Cancer Research Center discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract
Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!
PUBLICATIONS (Ranked by impact factor of the journal)

Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in Two Mouse Models of Chronic Pancreatitis
The authors investigated the roles of complement component 5 (C5) in pancreatic fibrogenesis in mice and patients. Direct effects of C5 were studied in cultured primary cells. [Gastroenterology] Abstract | Full Article

Set7/9 Regulates Cytokine-Induced Expression of Inducible Nitric Oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell
Given that inflammation is a central component of β cell dysfunction in type 1 and type 2 diabetes, investigators elucidated the role of Set7/9 in proinflammatory cytokine signaling in β cells. [J Biol Chem]
Abstract | Full Article

Streptozotocin Induces Endoplasmic Reticulum Stress and Apoptosis via Disruption of Calcium Homeostasis in Mouse Pancreas
Scientists hypothesized that streptozotocin disrupts calcium homeostasis and the altered intracellular calcium levels may induce cell death. Depletion of calcium from the endoplasmic reticulum (ER) leads to ER-stress and can induce apoptosis. [Mol Cell Endocrinol] Abstract

Fibrin Supports Human Fetal Islet-Epithelial Cell Differentiation via p70s6k and Promotes Vascular Formation during Transplantation
Scientists investigated how fibrin promotes human fetal pancreatic cell differentiation in vitro and in vivo. Fibrin-cultured human fetal pancreatic cells had significantly increased expression of PDX-1, glucagon, insulin, and VEGF-A, along with increased integrin αVβ3 and phosphorylated FAK and p70s6k. [Lab Invest] Abstract


Loss of Polarity Protein AF6 Promotes Pancreatic Cancer Metastasis by Inducing Snail Expression
Researchers demonstrated that depletion of AF6 markedly promotes proliferation and metastasis of pancreatic cancer cells through upregulation of the expression of Snail protein, and this requires the nuclear localization of AF6. [Nat Commun] Abstract

Expression of E-Cadherin Repressors SNAIL, ZEB1 and ZEB2 by Tumor and Stromal Cells Influences Tumor-Budding Phenotype and Suggests Heterogeneity of Stromal Cells in Pancreatic Cancer
Investigators characterized the tumor-budding- and stromal cells in pancreatic ductal adenocarcinoma at protein and mRNA levels concerning factors involved in epithelial–mesenchymal transition. [Br J Cancer] Abstract

The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells
Scientists investigated reactive oxygen species (ROS) and caspases in human pancreatic cancer cells undergoing two different types of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell death, apoptosis and necroptosis. [PLoS One] Full Article

Autophagy Sustains the Survival of Human Pancreatic Cancer PANC-1 Cells under Extreme Nutrient Deprivation Conditions
Researchers elucidated the role of autophagy in promoting the survival of human pancreatic cancer PANC-1 cells exposed to nutrient-deprived media lacking glucose, amino acids, and serum. [Biochem Biophys Res Commun] Abstract

Learn More: Standardized Tools for Cancer Research
Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes
The author introduces emerging concepts of islet macrophage biology that may challenge the perception that macrophage accumulation in islets is merely a pathological feature of type 2 diabetes. [Mol Endocrinol] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
RCSI and AMBER Led EU Consortium Receives €8.9 Million Funding to Develop Materials and Cell Based Treatments for Diabetes
Major new EU funding for research into diabetes was announced by a group led by RCSI (Royal College of Surgeons in Ireland) and AMBER (Advanced Materials for Bioengineering Research). The DRIVE (Diabetes Reversing Implants with enhanced Viability and long-term Efficacy) consortium involves fourteen partners from seven European countries and has received €8.9 million funding as part of the Horizon 2020 – Research and Innovation Framework Programme. [Royal College of Surgeons in Ireland] Press Release

Cancer Prevention and Research Institute of Texas Awards 41 New Grants
The Cancer Prevention and Research Institute of Texas awarded 28 grants through its academic research program, 11 grants through its prevention program and two grants through its product development research program. [Cancer Prevention and Research Institute of Texas] Press Release

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FTC, All 50 States and D.C. Charge Four Cancer Charities with Bilking Over $187 Million from Consumers
The Federal Trade Commission and 58 law enforcement partners from every state and the District of Columbia have charged four sham cancer charities and their operators with bilking more than $187 million from consumers. [Federal Trade Commission] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Death
September 15-19, 2015
Cold Spring Harbor, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW PhD Position – Pancreatic Diseases (University Hospital Zurich)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Metabolic Fingerprinting of Gestational Diabetes Mellitus (CEU San Pablo University)

Postdoctoral Position – Cancer (MD Anderson Cancer Center)

Research Fellow – Systems Biology (University of Glasgow)

PhD Studentships – Diabetes Research (Diabetes UK)

Postdoctoral Position – Type 1 Diabetes Research (KU Leuven)

Research Assistant/Associate – Pancreatic Cancer (University of Glasgow)

Postdoctoral Position – Obesity and Diabetes Research (University of Iowa)

Postdoctoral Research Fellow – Mechanisms of Cell Death of Normal Tissue Stem Cells (Memorial Sloan Kettering Cancer Center)

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