Volume 5.08 | Mar 4

Pancreatic Cell News 5.08 March 4, 2014
Pancreatic Cell News
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Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High Fat Diet Condition
Scientists generated gastric inhibitory polypeptide (GIP)-GFP knock-in mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous state in mice on control fat diet and high fat diet in vivo and in vitro. [Diabetes] Abstract
Directed Differentiation of Pluripotent Stem Cells - A Cell Stem Cell Poster
PUBLICATIONS (Ranked by impact factor of the journal)

Alarmin High-Mobility Group B1 (HMGB1) Is Regulated in Human Adipocytes in Insulin Resistance and Influences Insulin Secretion in ß-Cells
Investigators aimed to characterize the effect of insulin resistance on HMGB1 in adipose tissue and to examine its potential role as a metabolic regulator in ß-pancreatic cells. [Int J Obes] Abstract

Protein Tyrosine Phosphatase-1B Modulates Pancreatic ß-Cell Mass
Researchers studied the role of protein tyrosine phosphatase 1B (PTP1B) in pancreatic ß-cells. Silencing of PTP1B expression in a pancreatic ß-cell line revealed the significance of this endoplasmic reticulum bound phosphatase in the regulation of cell proliferation and apoptosis. [PLoS One] Full Article

Bone Morphogenetic Protein Signaling Protects against Cerulein-Induced Pancreatic Fibrosis
In vitro, bone morphogenetic protein (BMP)2 inhibited TGF-ß-induced extracellular matrix protein fibronectin production in wild-type pancreatic stellate cells (PSCs); this effect was abolished in BMPR2+/- PSCs. [PLoS One] Full Article

Apoptosis Induced by Islet Amyloid Polypeptide Soluble Oligomers Is Neutralized by Diabetes-Associated Specific Antibodies
Scientists describe the isolation of Type 2 diabetes-associated islet amyloid polypeptide soluble cytotoxic oligomers; these oligomers induced apoptosis in cultured pancreatic cells, permeated model lipid vesicles and interacted with cell membranes following complete internalization. [Sci Rep] Full Article


Targeting the Prohibitin Scaffold-CRAF Kinase Interaction in RAS-ERK-Driven Pancreatic Ductal Adenocarcinoma
Prohibitin (PHB) expression was analyzed in human pancreatic cancer cell lines, normal pancreas, and pancreatic ductal adenocarcinoma tissue. Furthermore, genetic ablation or pharmacological inhibition of PHB was performed to determine its role in growth, migration, and signaling of pancreatic cancer cells in vitro and in vivo. [Mol Cancer] Full Article

Complementary Induction of Immunogenic Cell Death by Oncolytic Parvovirus H-1PV and Gemcitabine in Pancreatic Cancer
Researchers showed that in human pancreatic cancer cells, oncolytic parvovirus H-1 activated multiple interconnected death pathways but failed to induce calreticulin exposure or ATP release. [J Virol] Abstract

Orai1 and STIM1 Mediate SOCE and Contribute to Apoptotic Resistance of Pancreatic Adenocarcinoma
Researchers demonstrated that ORAI1 and STIM1 mediate store-operated calcium entry (SOCE) in pancreatic adenocarcinoma cell lines. [Biochim Biophys Acta] Abstract

The Multifunctional Growth Factor Midkine Promotes Proliferation and Migration in Pancreatic Cancer
Scientists investigated the molecular role of Midkine in pancreatic cancer. It was found that Midkine is elevated in pancreatic ductal adenocarcinoma and differentially expressed in other histological subtypes of pancreatic cancer, whereas normal pancreatic cells did not express Midkine. [Mol Cancer Res] Abstract

Gemcitabine Resistance Is Associated with Epithelial-Mesenchymal Transition and Induction of HIF-1 in Pancreatic Cancer Cells
Gemcitabine-resistant pancreatic cancer cells acquired epithelial-mesenchymal transition phenotype. Moreover, gemcitabine-resistant cells have increased migration and invasion activities. [Curr Cancer Drug Targets] Abstract

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Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes
The authors summarize recent advances in the differentiation of pancreatic ß cells from pluripotent stem cells (PSCs), and describe the challenges for their clinical use in diabetes cell therapy. Furthermore, they discuss the potential use of patient-specific PSCs as an in vitro model, providing new insights into the pathophysiology of diabetes. [Stem Cell Rev] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
US FDA Approves Bydureon® Pen (Exenatide Extended-Release for Injectable Suspension) for Once-Weekly Treatment of Adults with Type 2 Diabetes
AstraZeneca announced that the US Food and Drug Administration (FDA) has approved the BYDUREON® Pen 2 mg as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [AstraZeneca] Press Release

DSI and Nova Sign Supply Agreement to Manufacture Telemetry Implant for Diabetes Research
Data Sciences International (DSI) announced that Nova Biomedical (Nova) and DSI have signed a supply agreement for the development and manufacture of a fully implanted telemetry device for the continuous measurement of blood glucose in animal research applications. [Data Sciences International] Press Release

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National Cancer Institute Releases Report Outlining Scientific Framework to Address Pancreatic Cancer: A Statement from The Pancreatic Cancer Action Network
The Pancreatic Cancer Action Network commends the National Cancer Institute, under the leadership of Harold E. Varmus, M.D., for issuing a report that takes important steps needed to make significant advances for one of The United States’ deadliest cancers. The report is a result of the Recalcitrant Cancer Research Act which was signed into law in January 2013 following a five-year push from the Pancreatic Cancer Action Network and its nationwide grassroots network. [Pancreatic Cancer Action Network] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW EMBO | EMBL Symposium: Translating Diabetes
April 30 – May 3, 2014
Heidelberg, Germany

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

NEW PhD Studentship – Molecular Drug Resistance (Institute of Cancer Research)

NEW Postdoctoral Position – Diabetes (Université de Sherbrooke)

NEW Postdoctoral Position – Diabetes Research (Tel Aviv University)

NEW Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

PhD Studentship – Pancreatic Ductal Adenocarcinoma (Institute of Cancer Research)

Postdoctoral Position – Diabetes (Washington University School of Medicine)

Postdoctoral Research Fellow/Associate – Diabetes, Metabolism and Molecular Endocrinology (University of Illinois)

Postdoctoral Positions – Cancer and Diabetes (University of Pennsylvania)

Postdoctoral Fellow – Stem Cell Biology (McEwen Centre for Regenerative Medicine/University Health Network)

Postdoctoral Associate Specialist – Human Pancreatic Stem Cell Research (The Nestlé Institute of Health Sciences)

Postdoctoral Fellowship Position – Mechanisms of Action in Obesity and Diabetes Pathogenesis (NIH/NIDDK)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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