Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Metformin Boosts Anti-tumor Immunity and Improves Prognosis in Upfront Resected Pancreatic Cancer: An Observational Study

[JNCI-Journal Of The National Cancer Institute] Researchers investigated the influence of metformin on patient survival and its potential correlation with distinct immune profiles in PDAC tumors.

Unveiling the Role of PYGB in Pancreatic Cancer: A Novel Diagnostic Biomarker and Gene Therapy Target

[Journal Of Cancer Research And Clinical Oncology] Scientists constructed a risk diagnostic model of pancreatic cancer (PC)-related genes by WGCNA and LASSO regression and found PYGB, an essential gene in PC. Then, we explored the pro-carcinogenic role of Brain glycogen phosphorylase in PC by in vivo and in vitro experiments.

Rintatolimod in Advanced Pancreatic Cancer Enhances Anti-Tumor Immunity through Dendritic Cell-Mediated T Cell Responses

[Clinical Cancer Research] Investigators studied the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of advanced PDAC patients.

Identification of HDAC9 and ARRDC4 As Potential Biomarkers and Targets for Treatment of Type 2 Diabetes

[Scientific Reports] Investigators identified the key potential insulin resistance-related genes and investigated their correlation with immune cell infiltration in type 2 diabetes.

The Porcine Islet-Derived Organoid Showed the Characteristics As Pancreatic Duct

Researchers elucidated the characteristics of porcine islet organoids derived from porcine islets as a cell source for transplantation. Isolated porcine islets were 3D-cultured using...

Retinol Binding Protein 4 and Type 2 Diabetes: From Insulin Resistance to Pancreatic β-Cell Function

The authors update and summarize recent studies focused on the relationship between retinol binding protein 4 and type 2 diabetes mellitus and its role...

Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

[Cancer Cell] Researchers identified three major morphological and functional variants that co-existed in varying proportions in all PDACs, displayed limited genetic diversity, and were associated with a distinct organization of the ECM.

NNT-AS1 in CAFs-Derived Exosomes Promotes Progression and Glucose Metabolism Through miR-889-3p/HIF-1α in Pancreatic Adenocarcinoma

[Scientific Reports] Transmission electron microscopy was used to examine exosomes secreted by PDAC patient-derived CAFs. qRT-PCR was used to evaluate the expression of NNT-AS1, miR-889-3p, and HIF-1.

Auranofin Repurposing for Lung and Pancreatic Cancer: Low CA12 Expression as a Marker of Sensitivity in Patient-Derived Organoids, with Potentiated Efficacy by AKT Inhibition

[Journal Of Experimental & Clinical Cancer Research] Our investigation employed a comprehensive drug screening of Auranofin in combination with eleven anticancer agents in cancerous PDAC and NSCLC patient-derived organoids, and non-cancerous pulmonary organoids.

ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells

[Oxidative Medicine And Cellular Longevity] Investigators performed a global gene expression analysis of human melanoma cells exposed to ACA-28 using a DNA microarray to comprehensively understand the biological cellular impact induced by ACA-28.

Transmembrane TNF-TNFR2 Signaling as a Critical Immunoregulatory Node in Pancreatic Cancer

Researchers described that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T cell dysfunction –...

Alterations in Exocrine Pancreatic Function after Acute Pancreatitis

[Pancreatology] Investigators discuss the epidemiology, pathophysiology, and clinical management of exocrine pancreatic dysfunction after acute pancreatitis while highlighting key knowledge gaps.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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