Volume 4.29 | Jul 30

Pancreatic Cell News 4.29 July 30, 2013
Pancreatic Cell News
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Ca2+ Release-Activated Ca2+ Channel Blockade as a Potential Tool in Antipancreatitis Therapy
In isolated mouse pancreatic acinar cells, Ca2+ release-activated Ca2+ channels channels were activated by blocking Ca2+ ATPase pumps in the endoplasmic reticulum with thapsigargin in the absence of external Ca2+. Ca2+ entry then occurred upon admission of Ca2+ to the extracellular solution. [Proc Natl Acad Sci USA] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but not Adult, Pancreatic Islets
Inactivation of vascular endothelial growth factor-A early in development dramatically reduced pancreatic and islet vascularization, leading to reduced ß-cell proliferation in both developing and adult islets and, ultimately, reduced ß-cell mass and impaired glucose clearance. [Diabetes] Abstract

Enrichment of Human Embryonic Stem Cell-Derived NKX6.1-Expressing Pancreatic Progenitor Cells Accelerates the Maturation of Insulin-Secreting Cells In Vivo
The relative contributions of NKX6.1-negative versus NKX6.1-positive cell fractions to the maturation of functional ß-cells remain unclear. To address this scientists generated two distinct pancreatic progenitor cell populations using modified differentiation protocols. [Stem Cells] Abstract

Bach1 Deficiency Protects Pancreatic ß-Cells from Oxidative Stress Injury
The role of BTB and CNC homology 1 (Bach1) in the development of diabetes is unclear. Heme oxygenase-1 expression in the liver, white adipose tissue and pancreatic islets was markedly up-regulated in Bach1-deficient mice. [Am J Physiol Endocrinol Metab] Abstract

Extracellular Matrix Composition Significantly Influences Pancreatic Stellate Cell (PSC) Gene Expression Pattern: Role of Transgelin in PSC Function
In vitro protocols examining PSC biology have usually involved PSCs cultured on plastic, a non-physiological surface. Culture of PSCs on different matrices significantly affected their gene expression pattern. [Am J Physiol Gastrointest Liver Physiol] Abstract

Proteomic Analysis of Apoptotic and Oncotic Pancreatic Acinar AR42J Cells Treated with Caerulein
Scientists determined the differentially expressed proteins in the pancreatic acinar cells undergoing apoptosis and oncosis stimulated with caerulein to explore different cell death processes of the acinar cell. [Mol Cell Biochem] Abstract


miR-99b-Targeted mTOR Induction Contributes to Irradiation Resistance in Pancreatic Cancer
Ionizing radiation promoted mTOR expression and activation in pancreatic cancer cells through reducing microRNA (miR)-99b expression, which negatively regulated mTOR. [Mol Cancer] Abstract | Full Article

Knockdown of Oct4 and Nanog Expression Inhibits the Stemness of Pancreatic Cancer Cells
Double knockdown of Oct4 and Nanog demonstrated that Oct4 and Nanog significantly reduced proliferation, migration, invasion, chemoresistance, and tumorigenesis of pancreatic cancer stem cells in vitro and in vivo. [Cancer Lett] Abstract

Cooperation among Numb, MDM2 and p53 in the Development and Progression of Pancreatic Cancer
Researchers studied the expression of Numb, MDM2 and p53 for clinical significance in pancreatic cancer (PC) and their functional relationship in regulating biological behaviors of PC cells. [Cell Tissue Res] Abstract

Tumor Protein D52 Controls Trafficking of an Apical Endolysosomal Secretory Pathway in Pancreatic Acinar Cells
Researchers showed that tumor protein D52 is highly expressed in endosomal compartments following pancreatic acinar stimulation and regulates apical exocytosis of an apically directed endolysosomal compartment. [Am J Physiol Gastrointest Liver Physiol] Abstract

Structure-Activity Relationship (SAR) of Withanolides to Inhibit Hsp90 for Its Activity in Pancreatic Cancer Cells
Researchers investigated the SAR of withanolides for their inhibition of Hsp90 and anti-proliferative activities in pancreatic cancer cells. [Invest New Drugs] Abstract

Differentiation Doesn't Have to be Difficult - Get Easy, Standardized hPSC Differentiation
Current Status of Islet Encapsulation
The authors provide a review of cell encapsulation of islets for the treatment of type 1 diabetes including a historical perspective, current research findings, and future studies. [Cell Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
U.S. FDA Acknowledges Receipt of Resubmission of the New Drug Application for Investigational Compound Dapagliflozin for the Treatment of Type 2 Diabetes
AstraZeneca and Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration (FDA) has acknowledged receipt of the New Drug Application resubmission for investigational drug dapagliflozin for the treatment of adults with type 2 diabetes. [Bristol-Myers Squibb Company]
Press Release

Investigation into GLP-1 Based Diabetes Therapies Concluded
The European Medicines Agency’s Committee for Medicinal Products for Human Use has finalized a review of GLP-1-based diabetes therapies. The Committee concluded that presently available data do not confirm recent concerns over an increased risk of pancreatic adverse events with these medicines. [European Medicines Agency] Press Release

Merck Statement Regarding CHMP Review of Incretin-Based Therapies for Type 2 Diabetes, Including Sitagliptin
Merck issued a statement regarding the conclusion of the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) review of GLP-1, or incretin-based, therapies, including sitagliptin. [Merck Sharp & Dohme Corporation] Press Release

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NEW Cell Based Assays
November 18-19, 2013
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Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Fellow – Pancreatic Beta Cell Regeneration and Survival (Oklahoma Medical Research Foundation)

NEW Research Associate – Pancreatic Cancer (Fred Hutchinson Cancer Research Center)

NEW Senior Scientist – Pancreas Development (AstraZeneca)

Postdoctoral Fellow – Diabetes Research (Sanford Health)

Postdoctoral Researcher – Molecular Determinants of Resistance to Chemotherapy and Radiation (The Ohio State University – Comprehensive Cancer Center)

Postdoctoral Electrophysiologist (University of Alberta)

Postdoctoral Position – Pluripotent Stem Cells to Islets (INSERM)

Postdoctoral Research Fellow – Platelet Biology and Diabetes (Thomas Jefferson University, Cardeza Foundation for Hematologic Research)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

PhD Positions – Molecular Mechanisms Controlling Acinar Cell Proliferation (University Hospital Zuerich)

Postdoctoral Researcher (The University of Texas Health Science Center at San Antonio)

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