Volume 1.16 | Aug 10

Pancreatic Cell News 1.16, August 10, 2010.


Small-Molecule Inducers of Insulin Expression in Pancreatic Alpha Cells  ShareThis
High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha cells to adopt several morphological and gene expression features of a beta cell state. [ Proc Natl Acad Sci U S A]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)


INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells
Results suggest that apoptosing INS-1 cells shed microparticles that may stimulate PSP/reg induction in neighboring cells, a mechanism that may facilitate the recovery of beta cell mass in HNF1A-maturity-onset-diabetes-of-the-young. [Diabetes]

Transgenic Expression of Haem Oxygenase-1 in Pancreatic Beta Cells Protects Non-Obese Mice Used as a Model of Diabetes from Autoimmune Destruction and Prolongs Graft Survival Following Islet Transplantation
Transgenic overexpression of Ho-1 in beta cells protected NOD mice from diabetes and delayed the autoimmune destruction of islet grafts, providing valuable insight into the development of better strategies for clinical islet transplantation in patients with type 1 diabetes. [Diabetologia]

Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic Beta Cells
Researchers found that insulin secretion and content are diminished by beta-hydroxy-beta-methylglutaryl-coenzyme A inhibitor lovastatin but not by lipoprotein depletion from the culture medium in MIN6 beta cells. [Endocrinology]

Identification of the Ectonucleotidases Expressed in Mouse, Rat and Human Langerhans Islets: Potential Role of NTPDase3 in Insulin Secretion
All pancreatic endocrine cells express NTPDase3, which was shown to modulate insulin secretion in rat INS-1 (832/13) beta cells. Ecto-5′-nucleotidase is expressed in rat Langerhans islet cells but is absent in human and mouse endocrine cells. [Am J Physiol Endocrinol Metab]

Transgenic Overexpression of Active Calcineurin in Beta Cells Results in Decreased Beta Cell Mass and Hyperglycemia
Researchers identify calcineurin as an important factor in controlling glucose homeostasis and indicate that chronic depolarization leading to increased calcineurin activity may contribute, along with other genetic and environmental factors, to beta cell dysfunction and diabetes. [PLoS One]


Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis
Results establish a mechanistic rationale for Src inhibition with dasatinib as a therapeutic target in the treatment of pancreatic cancer and identify potential biomarkers of resistance to Src inhibition. [Mol Cancer Ther]

Nuclear Expression of Interleukin-33 in Pancreatic Stellate Cells
Activated pancreatic stellate cells (PSCs) expressed IL-33 in the nucleus. IL-33 might regulate the PDGF-induced proliferation in PSCs. [Am J Physiol Gastrointest Liver Physiol]

Transcriptional Regulation of CXC-ELR Chemokines KC and MIP-2 in Mouse Pancreatic Acini
Acinar cells are a likely source of KC and MIP-2 up-regulation during pancreatitis. This upregulation is dependent on calcium and PKC. MIP-2 upregulation requires both NFkappa-B and AP-1 in these cells. [Am J Physiol Gastrointest Liver Physiol]

Phylogenetic and Regulatory Region Analysis of Wnt5 Genes Reveals Conservation of a Regulatory Module with Putative Implication in Pancreas Development
Researchers concluded that during evolution the Wnt5 gene has been duplicated in early vertebrates, and that some paralogs conserved a module within their regulatory region functionally related to embryonic development of pancreas. [Biol Direct]

Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in “Stem-Cell-Like” Tumor Cells
Researchers found chemoradiation-resistant pancreatic cancer cells to be similar to cancer stem cells (CSCs) and to undergo epithelial-mesenchymal transition (EMT), suggesting that chemoradiation resistance-induced EMT is linked to CSC generation. [Dig Dis Sci]



Celgene/Abraxis Receive Verbal Confirmation of Early Termination of Hart-Scott-Rodino (HSR) 30-Day Waiting Period
Celgene Corporation announced that it has received verbal confirmation of early termination of the Hart-Scott-Rodino Act 30-day waiting period without the United States Federal Trade Commission requesting additional information with regard to Celgene’s pending acquisition of Abraxis Bioscience, Inc. [Celgene Corporation Press Release]

GlaxoSmithKline and Amplimmune Form Global Strategic Collaboration
Amplimmune, Inc. announced that it has entered into a broad strategic alliance with GlaxoSmithKline (GSK) to further develop PD-1 targeting therapies that may be effective in the treatment of cancer and other diseases. GSK will obtain exclusive worldwide rights to AMP-224 as well as other potential next generation fusion proteins that target PD-1. [Amplimmune, Inc. Press Release]

Living Cell Technologies Receives Approval to Expand DIABECELL® New Zealand Trial
Living Cell Technologies Limited reported that the Minister of Health has approved an addition to the New Zealand Phase II clinical trial of DIABECELL® to include more patients. [Living Cell Technologies Limited Press Release]

Mixtard 30 — Going, Going, Gone?
The drug company Novo Nordisk announced that its only conventional human biphasic insulin, human Mixtard 30, would no longer be available in the UK from January 2011, a decision that affects an estimated 90,000 patients. [Drug and Therapeutics Bulletin]

Panel Recommends Defining Select Agents by DNA Sequence
The way to bring synthetically designed genomes that could be potentially as deadly as known pathogens under regulation, according to a new National Academies report, is to develop a new system of defining select agents based on DNA sequences. [ScienceInsider]

Free Access to U.S. Research Papers Could Yield $1 Billion in Benefits
A new economic analysis finds that making taxpayer-funded scientific papers freely available would yield more than $1 billion in benefits to the U.S. economy over 30 years–five times the costs of archiving the papers. [ScienceInsider]


Scientists Decry Proposed Ban on Chimp Research
In the latest twist in the protracted debate over the use of chimpanzees in biomedical research, U.S. senators introduced the Great Ape Protection Act, an identical bill to one that has been stuck in a House of Representatives committee for more than a year. [Senate, United States]

Senate Bill Would Encourage Drugs Targeting Rare Kids’ Diseases
A group of bipartisan senators introduced legislation to entice drug makers to focus more intently on cures for uncommon children’s diseases. [Senate, United States]

FDA Issues Assessments of the 510(k) Program and Use of Science in Decision-Making
The U.S. Food and Drug Administration issued two comprehensive evaluations containing recommendations that address three key objectives of the agency’s public health mission as it relates to medical devices — foster device innovation, create a more predictable regulatory environment, and enhance device safety. [Food and Drug Administration, United States]

Solicitation for Nominations: New Clinical Preventive Health for the United States Preventive Services Task Force (2010-19117) [Agency for Healthcare Research and Quality, United States]

National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting (2010-19210) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

Coordinating and Bioinformatics Unit for the Mouse Metabolic Phenotyping Centers and the Diabetic Complications Consortium (U24) (RFA-DK-10-007) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

NIH Common Fund Transformative Research Projects Program (R01) (RFA-RM-10-010) [National Institutes of Health, United States]

Clinical Studies of Safety and Effectiveness of Orphan Products Research Project Grant (R01) [Docket No. FDA-2010-N-0394] [Food and Drug Administration, United States]

Comprehensive List of Guidance Documents at the Food and Drug Administration [Docket No. FDA-1998-N-0050] (formerly Docket No. 1998N-0046) [Food and Drug Administration, United States]

Endocrinologic and Metabolic Drugs Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States]

EVENTS (Listed by Date)

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences
September 4-7, 2010
Barcelona, Spain

The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) 2010 Scientific Meeting 
September 9-10, 2010
Oxford, United Kingdom

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

Institute of Medicine – University of Illinois at Chicago Midwest Conference on Diabetes and Obesity
September 21, 2010
Chicago, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

2010 American Pancreatic Association (APA) Annual Meeting
November 3-6, 2010
Chicago, United States

Select Biosciences International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Cell Therapy Technologist (Opexa Therapeutics)

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