| | | PUBLICATIONS (Ranked by impact factor of the journal) |
DIABETES & PANCREATITIS
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response
Researchers showed that germline and β cell-specific disruption of the lysine acetyltransferase 2B (Kat2b) gene in mice leads to impaired insulin secretion and glucose intolerance. [Cell Rep] Full Article
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PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery
Using the diabetic Goto-Kakizaki rat model, researchers demonstrated that Roux-en-Y gastric bypass restores normal glucose regulation of glucagon and insulin secretion and normalizes islet morphology. [Cell Rep] Full Article
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sept7b Is Required for the Differentiation of Pancreatic Endocrine Progenitors
Investigators showed, by functional manipulation techniques in transgenic zebrafish lines that suppression of sept7b, the zebrafish ortholog of human SEPT7, profoundly increased the number of endocrine progenitors but limited their differentiation, leading to reduction in β- and α-cell mass. [Sci Rep] Full Article
TCF7L2 Involvement in Estradiol- and Progesterone-Modulated Islet and Hepatic Glucose Homeostasis
To evaluate the role of transcription factor 7-like 2 (TCF7L2), a key regulator of glucose homeostasis, in estradiol (E2) and progesterone (P4)-modulated glucose metabolism, mouse insulinoma cells and human liver cancer cells were treated with physiological concentrations of E2 or P4 in the up- and down-regulation of TCF7L2. [Sci Rep] Full Article
Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes
Researchers examined whether demethylated circulating free amylin DNA may serve as a biomarker of β-cell death in type 1 diabetes. β cells showed unique methylation patterns within the amylin coding region that were not observed with other tissues. [PLoS One] Full Article
Proteasome Inhibitors, Including Curcumin, Improve Pancreatic β-cell Function and Insulin Sensitivity in Diabetic Mice
Investigators showed that curcumin prevents β-cell failure in a mouse model of uncompensated obesity-related insulin resistance. [Nutr Diabetes] Full Article
PANCREATIC CANCER
Identification of Pyrazolopyridazinones as PDEδ Inhibitors
The authors reported that the small-molecule Deltarasin binds to the prenyl-binding pocket of PDEδ, and impairs Ras enrichment at the plasma membrane, thereby affecting the proliferation of KRas-dependent human pancreatic ductal adenocarcinoma cell lines. Here, using structure-based compound design, they have identified pyrazolopyridazinones as a novel, unrelated chemotype that binds to the prenyl-binding pocket of PDEδ with high affinity, thereby displacing prenylated Ras proteins in cells. [Nat Commun] Full Article
Hypoxia-Induced Oxidative Stress Promotes MUC4 Degradation via Autophagy to Enhance Pancreatic Cancer Cells Survival
Scientists report that MUC4 protein stability is drastically affected in pancreatic cancer, under hypoxic condition in a hypoxia inducible factor 1α-independent manner. Mechanistically, they demonstrated that hypoxia-mediated induction of reactive oxygen species promotes autophagy by inhibiting pAkt/mTORC1 pathway, one of the central regulators of autophagy. [Oncogene] Abstract
Calcium Sensing Receptor Suppresses Human Pancreatic Tumorigenesis through a Novel NCX1/Ca2+/β-Catenin Signaling Pathway
The authors revealed that the expression of calcium sensing receptor was consistently downregulated in the primary cancer tissues from pancreatic cancer patients, which was correlated with tumor size, differentiation and poor survival of the patients. [Cancer Lett] Abstract
TMEM45B Promotes Proliferation, Invasion and Migration and Inhibits Apoptosis in Pancreatic Cancer Cells
Scientists showed that TMEM45B exhibited high expression in pancreatic cancer tissues and cell lines compared with the normal pancreatic tissues and cells. [Mol Biosyst] Abstract
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| | | REVIEWS |
Stem/Progenitor Cells and Reprogramming (Plasticity) Mechanisms in Liver, Biliary Tree and Pancreas
Stem/progenitor cells and their descendant maturational lineages and reprogramming (plasticity) comprise phenomena and mechanisms regulating diverse aspects of the biology and pathobiology of liver, biliary tree and pancreas. A network of stem cells within the biliary tree transition into later stage stem/progenitors found in or near the canals of Hering in liver and in committed progenitors within pancreatic duct glands of pancreas and then differentiate into maturational lineages of parenchymal cells in these organs. [Hepatology] Abstract
Pancreatic Cancer
The authors summarize the current understanding of the salient pathophysiological, molecular, translational and clinical aspects of pancreatic cancer. In addition, they present an outline of potential future directions for research and patient management. [Nat Rev Dis Primers] Abstract
Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
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