Volume 7.10 | Mar 15

Pancreatic Cell News 7.10 March 15, 2016
Pancreatic Cell News
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The Next Step in Preventing Diabetes
A team of scientists have shown in a preclinical model that specifically modified insulin mimetopes may lead to an immune tolerance. The results may be a step to improved prevention of type 1 diabetes. [Press release from Helmholtz Zentrum München discussing online prepublication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery
Researchers developed innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 hours. [Adv Mater] Abstract | Press Release

Externalized Decondensed Neutrophil Chromatin Occludes Pancreatic Ducts and Drives Pancreatitis
Scientists showed that aggregates form inside pancreatic ducts in humans and mice occluding pancreatic ducts and thereby driving pancreatic inflammation. Experimental models indicated that peptidyl arginine deiminase-4 (PADI4) is critical for intraductal aggregate formation and that PADI4-deficiency abrogates disease progression. [Nat Commun] Full Article

B-Lymphocytes Expressing an Immunoglobulin Specificity Recognizing the Pancreatic ß-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice
Researchers generated and characterized NOD mice transgenically expressing an immunoglobulin molecule representative of a large proportion of naturally occurring islet-infiltrating B-lymphocytes in NOD mice recognizing the neuronal antigen peripherin. [Diabetes] Abstract

Elevated Circulating Stearic Acid Leads to a Major Lipotoxic Effect on Mouse Pancreatic Beta Cells in Hyperlipidemia via a miR-34a-5p-Mediated PERK/p53-Dependent Pathway
Investigators examined the adverse effects of stearic acid on beta cells and the potential mechanisms through which these are mediated. [Diabetologia] Abstract

Inhibition of Renalase Expression and Signaling Has Antitumor Activity in Pancreatic Cancer
Researchers showed that renalase expression is increased in pancreatic cancer tissue and that it functions as a growth factor. [Sci Rep] Full Article

MicroRNA-454 Regulates Stromal Cell Derived Factor-1 in the Control of the Growth of Pancreatic Ductal Adenocarcinoma
Investigators analyzed the control of a HIF-1 target, stromal cell derived factor-1, in pancreatic ductal adenocarcinoma (PDAC) cells. They detected significantly more CD68+ macrophages in the PDAC, compared to normal human pancreas. [Sci Rep] Full Article

General Control Nonderepressible Kinase 2 (GCN2) Deletion Predisposes to Asparaginase-Associated Pancreatitis in Mice
Researchers determined the consequences of asparaginase treatment on the pancreata of mice with GCN2 intact (WT) or deleted (ΔGcn2). Mean pancreas weights in ΔGcn2 mice treated with asparaginase for 8 days were increased above all other groups. [Am J Physiol Gastrointest Liver Physiol] Abstract

Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic Beta Cells
Scientists report that cannabinoid 1 receptors regulate the expression of the anti-apoptotic protein Bcl-2 and cell cycle regulator cyclin D2 in pancreatic β cells. [PLoS One] Full Article

Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma
The authors aimed to determine the frequency and extent of intratumoral and metastatic lymph node Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation heterogeneity of resected pancreatic ductal adenocarcinoma. [Pancreas] Abstract

Take the If out of Diff: Definitive Endoderm
Pancreatic Regulation of Glucose Homeostasis
The authors summarize the interplay of the pancreas with various other organs and tissues that maintain glucose homeostasis. Furthermore, anti-diabetic drugs and their impact on signaling pathways underlying the network are discussed. [Exp Mol Med] Full Article

Recent Progress in Genetic and Epigenetic Research on Type 2 Diabetes
Investigators briefly summarize the recent progress in the genetic and epigenetic research on type 2 diabetes (T2DM) and discuss how environmental factors, genetics and epigenetics can interact in the pathogenesis of T2DM. [Exp Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
LabStyle Innovations Granted U.S. Patent Expanding IP for Fluids Testing into Industrial Applications via Mobile Devices and Apps
LabStyle Innovations Corp. announced the U.S. Patent and Trademark Office has issued the company patent #9257038 titled, “Fluids testing apparatus and methods of use.” The invention addresses mobile, hand held, miniature laboratory systems and testing of fluids including bodily fluids such as blood, urine, saliva, and amniotic fluid, as well as non-bodily fluids for industrial, defense and security applications including environmental and food safety. [LabStyle Innovations Corp.] Press Release

Nemaura Medical Announces Receipt of Notification of CE Approval for Its SugarBEAT® Continuous Glucose Monitoring System
Nemaura Medical Inc. announced that it has received notification of CE Approval for its sugarBEAT® system from its European Notified Body. The device for which CE grant notice has been approved was used in a 160 patient day study generating over 1500 paired data points, and retrospective evaluation of the glucose data. [Nemaura Medical Inc.] Press Release

Cellnovo and Roche Sign Commercial Blood Glucose Monitor Agreement
Cellnovo Group announces the signing of a commercial agreement to integrate Roche Diabetes Care’s market leading Accu-Chek® Aviva and Accu-Chek® Performa blood glucose monitoring platforms into the Cellnovo diabetes management system. [Cellnovo Group] Press Release

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NEW Cell Signaling in Cancer: From Mechanisms to Therapy
June 5-10, 2016
Snowmass Village, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Fellowship – Pancreatic Cancer (Fred Hutchinson Cancer Research Center)

NEW Master Studentship – Exercise and Diabetes (Swansea University)

NEW Part Time Researcher – Diabetes (University of Bergen)

Postdoctoral Research Fellowship – Pancreatic Cancer Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Fellowship – Surgical Oncology in Pancreatic Cancer (University of Nebraska Medical Center)

Postdoctoral Research Fellowship – Pancreatic Progenitors in Development (Johns Hopkins University Institute of Genetic Medicine)

Postdoctoral Fellowship – Metabolism and Cancer (Monash University)

Postdoctoral Fellowship – Mechanisms of Atherosclerosis, Diabetes and Obesity (Washington University School of Medicine)

Assistant Professor of Surgery – Molecular Biology and Pancreatic Development (University of Pittsburgh)

Postdoctoral Fellowship – Neural Mechanisms of Diabetes (Albert Einstein College of Medicine)

Faculty Position – Metabolic Disease Research (Lewis Katz School of Medicine)

Postdoctoral Fellowship – Diabetes (Danish Diabetes Academy)

Post-Doc Fellowship – Glucose Metabolism (Joslin Diabetes Center)

Post-Doc Researcher – Type 1 Diabetes (University of Turku)

MD/PhD Researcher – Biomedical Sciences (Hannover Medical School)

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