The Next Step in Preventing Diabetes
A team of scientists have shown in a preclinical model that specifically modified insulin mimetopes may lead to an immune tolerance. The results may be a step to improved prevention of type 1 diabetes. [Press release from Helmholtz Zentrum München discussing online prepublication in Nature Communications] Press Release|Full Article
Externalized Decondensed Neutrophil Chromatin Occludes Pancreatic Ducts and Drives Pancreatitis
Scientists showed that aggregates form inside pancreatic ducts in humans and mice occluding pancreatic ducts and thereby driving pancreatic inflammation. Experimental models indicated that peptidyl arginine deiminase-4 (PADI4) is critical for intraductal aggregate formation and that PADI4-deficiency abrogates disease progression. [Nat Commun] Full Article
Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma
The authors aimed to determine the frequency and extent of intratumoral and metastatic lymph node Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation heterogeneity of resected pancreatic ductal adenocarcinoma. [Pancreas] Abstract
REVIEWS
Pancreatic Regulation of Glucose Homeostasis
The authors summarize the interplay of the pancreas with various other organs and tissues that maintain glucose homeostasis. Furthermore, anti-diabetic drugs and their impact on signaling pathways underlying the network are discussed. [Exp Mol Med] Full Article
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INDUSTRY NEWS
LabStyle Innovations Granted U.S. Patent Expanding IP for Fluids Testing into Industrial Applications via Mobile Devices and Apps
LabStyle Innovations Corp. announced the U.S. Patent and Trademark Office has issued the company patent #9257038 titled, “Fluids testing apparatus and methods of use.” The invention addresses mobile, hand held, miniature laboratory systems and testing of fluids including bodily fluids such as blood, urine, saliva, and amniotic fluid, as well as non-bodily fluids for industrial, defense and security applications including environmental and food safety. [LabStyle Innovations Corp.] Press Release
Cellnovo and Roche Sign Commercial Blood Glucose Monitor Agreement
Cellnovo Group announces the signing of a commercial agreement to integrate Roche Diabetes Care’s market leading Accu-Chek® Aviva and Accu-Chek® Performa blood glucose monitoring platforms into the Cellnovo diabetes management system. [Cellnovo Group] Press Release
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