Type 2 Diabetes Drug Can Exhaust Insulin-Producing Cells
Long-term use of liraglutide, a substance that helps to lower blood sugar levels in patients with type 2 diabetes, can have a deteriorating effect on insulin-producing beta cells, leading to an increase in blood sugar levels. [Press release from Karolinska Institutet discussing online publication in Cell Metabolism] Press Release|Abstract|Graphical Abstract
IP Receptor Agonism Preserves Beta-Cell Function and Attenuates Albuminuria through Nephrin-Dependent Mechanisms
Scientists investigated the in vitro and in vivo effects of pharmacological agonism of the prostaglandin I2 (IP) receptor in pancreatic ß-cells and in glomerular podocytes. The IP receptor agonist MRE-269 increased intracellular cAMP, augmented glucose-stimulated insulin secretion (GSIS) and increased viability in MIN6 ß-cells and its pro-drug form, selexipag augmented GSIS and preserved islet ß-cell mass in diabetic mice. [Diabetes] Abstract
Cyclin-Dependent Kinase 2 Protects Podocytes from Apoptosis
Investigators found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predict progression of diabetic nephropathy, downregulated cyclin-dependent kinase 2 (CDK2). LPS-treatment of mice also reduced CDK2 expression. [Sci Rep] Full Article
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