Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology|
A formidable source of noncanonical signal transduction concepts is neural stem cells because these cells appear to have acquired unusual signaling interpretations to allow them to maintain their unique dual properties (self-renewal and multipotency). The authors discuss how such findings from the neural field can provide a blueprint for the identification of new molecular mechanisms regulating pancreatic biology, with a focus on Notch, Hes/Hey, and hedgehog pathways. [Diabetes] Abstract
Resting Beta-Cells – a Functional Reserve?
The authors posit that beta-cells rest and that studies of this normal feature of beta-cells could lead to new approaches for potentially reactivating and preserving beta-cell mass in order to treat diabetes. [Diabetes Metab] Abstract
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