Volume 6.43 | Nov 3

Pancreatic Cell News 6.43 November 3, 2015
Pancreatic Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Inactivation of TGF-β Receptor II Signaling in Pancreatic Epithelial Cells Promotes Acinar Cell Proliferation, Acinar-to-Ductal Metaplasia and Fibrosis during Pancreatitis
Investigators elucidated the molecular mechanisms underlying the effects of transforming growth factor-β (TGF-β) in pancreatic epithelial cells during tissue regeneration. [J Pathol] Abstract
Differentiation Doesn't Have to be Difficult - Get Easy, Standardized hPSC Differentiation
 
PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

The Soybean Peptide Vglycin Preserves the Diabetic β-Cells through Improvement of Proliferation and Inhibition of Apoptosis
Researchers present a polypeptide vglycin, which was isolated and purified from germinating pea seeds. Vglycin exhibited positive effects in our diabetic models by promoting the proliferation and suppressing the apoptosis and dedifferentiation of β-cells. [Sci Rep] Full Article

Evaluation of Low Doses BPA-Induced Perturbation of Glycemia by Toxicogenomics Points to a Primary Role of Pancreatic Islets and to the Mechanism of Toxicity
Scientists took a toxicogenomic approach to investigate the mechanisms of low-dose bisphenol A (BPA) toxicity in ex vivo cultures of primary murine pancreatic islets and hepatocytes. [Cell Death Dis] Full Article

Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells
Porosomes have been functionally reconstituted for the first time in live cells. Isolated Min6 porosomes reconstituted into live Min6 cells demonstrate augmented levels of porosome proteins and a consequent increase in the potency and efficacy of glucose-stimulated insulin release. [Endocrinology] Abstract

Parathyroid Hormone-Related Protein Interacts with the Transforming Growth Factor-β/Bone Morphogenetic Protein-2/Gremlin Signaling Pathway to Regulate Proinflammatory and Profibrotic Mediators in Pancreatic Acinar and Stellate Cells
Transforming growth factor β increased parathyroid hormone-related protein levels in acinar cells and pancreatic stellate cells through a Smad3-dependent pathway. [Pancreas] Abstract

PANCREATIC CANCER

Interplay between Gemcitabine and Erlotinib over Pancreatic Adenocarcinoma Cells
The authors investigated the molecular interplay in vitro between gemcitabine and erlotinib regarding their effects over cytotoxicity, proliferation, apoptosis, and invasion. [Pancreas] Abstract

Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer
Researchers evaluated the efficacy of combination of triptolide and oxaliplatin against pancreatic cancer. Highly aggressive pancreatic cancer cells were treated with oxaliplatin, low-dose triptolide, or a combination of both for 24–48 hours. [J Gastrointest Surg] Abstract

Cell Motility and Spreading Promoted by CEACAM6 through Cyclin D1/CDK4 in Human Pancreatic Carcinoma
Scientists used siRNA and forced-expression in multiple cell lines to define the role of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in the regulation of proliferation of pancreatic carcinoma in vitro and in vivo. Knockdown of endogenous CEACAM6 decreased proliferation of BxPC-3 and SW1990 cells. [Oncol Rep] Abstract

Ferulic Acid Decreases Cell Viability and Colony Formation while Inhibiting Migration of MIA PaCa-2 Human Pancreatic Cancer Cells In Vitro
Scientists examined the effects of ferulic acid, a phenolic compound, on gene expression, viability, colony formation and migration/invasion in the cultured MIA PaCa-2 human pancreatic cancer cell. [Gene] Abstract

Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
REVIEWS
The Role of Src Homology-2 Domain Containing Protein B (SHB) in Beta Cells
The authors describe the SH2-domain signaling protein SHB and its role in various physiological processes relating in particular to glucose homeostasis and beta cell function. [J Mol Endocrinol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
Merrimack and Baxalta Announce Enrollment of First Patient in Phase II Study of ONIVYDE™ (Irinotecan Liposome Injection) in Previously Untreated Front-Line Metastatic Pancreatic Cancer
Merrimack and Baxalta Incorporated jointly announced the enrollment of the first patient in an exploratory Phase II clinical study of ONIVYDE™ in previously untreated, metastatic pancreatic adenocarcinoma. [Merrimack Pharmaceuticals, Inc.] Press Release

$2.58 Million NIH Grant to Wayne State Aims to Improve Type 2 Diabetes Treatment
Zhengping Yi, Ph.D. is leading a research team that was awarded more than $2.5 million from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. The team will work to discover the abnormality in protein phosphatase 1 that contributes to the development of insulin resistance and type 2 diabetes. [Wayne State University] Press Release

GSK and Merck to Study Immunotherapy Combination as Potential Cancer Treatment
GSK and Merck announced the initiation of a Phase I clinical trial designed to evaluate GSK’s investigational immunotherapy GSK3174998 as monotherapy and in combination with Merck’s anti-PD-1 therapy, Keytruda® in patients with locally advanced, recurrent or metastatic solid tumor(s) that have progressed after standard treatment. [GlaxoSmithKline plc] Press Release

TSRI Team Wins $1.8 Million to Study Early Events in Cancer Metastasis
Scientists at The Scripps Research Institute (TSRI) have been awarded a grant of more than $1.8 million from the National Institutes of Health’s National Cancer Institute to investigate the molecular machinery involved in metastasis. [The Scripps Research Institute] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cells and Organoids as Models of Tissue Differentiation and Disease
January 12, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Scientist – Disease Gene Regulation (University of Oxford)

NEW Postdoctoral Research Scientist – Diabetes Genetics (University of Oxford)

NEW Postdoctoral Research Fellow – Immunometabolism (Karolinska Institute)

Diabetes Research – Beta-Cell Metabolism (Lund University)

Scientist – Preclinical Immunology (Kanyos Bio)

Postdoctoral Position – Diabetes (University of Geneva Medical School)

Senior Clinical Lecturer – Cancer & Inflammation (Queen Mary University of London)

Postdoctoral Fellowship – Action in Obesity and Diabetes Pathogenesis (National Institutes of Health Diabetes)

Postdoctoral Fellow – Diabetes and Metabolism (Johns Hopkins University)

Postdoctoral Research Fellow – Translational Research Program (Fred Hutchinson Cancer Research Center)


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