Volume 6.34 | Sep 1

Pancreatic Cell News 6.34 September 1, 2014
Pancreatic Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
The authors performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose homeostasis, in adolescent and very old mice. They observed a global methylation drift resulting in an overall more leveled methylome in old β cells. [Cell Metab] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

Identification of the Interaction of VP1 with GM130 which May Implicate in the Pathogenesis of CVB3-Induced Acute Pancreatitis
Researchers identified the host factor Golgi matrix protein 130 (GM130) as a novel target of coxsackievirus B3 (CVB3) during CVB3-induced acute pancreatitis. [Sci Rep] Full Article

Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells
Investigators explored the relationship between mouse maternal expressed gene 3 (Meg3) and the function of mouse beta cells in vitro and in vivo. [J Cell Physiol] Abstract

Primary Outgrowth Cultures Are a Reliable Source of Human Pancreatic Stellate Cells
Investigators examined whether outgrowth cultures from human surgical specimens exhibited reproducible phenotypic and functional characteristics of pancreatic stellate cells. [Lab Invest] Abstract

PANCREATIC CANCER

Myoferlin Plays a Key Role in VEGFA Secretion and Impacts Tumor-Associated Angiogenesis in Human Pancreas Cancer
Researchers showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. [Int J Cancer] Abstract

Prostaglandin E2 Activates the mTORC1 Pathway through an EP4/cAMP/PKA and EP1/Ca2+-Mediated Mechanism in the Human Pancreatic Carcinoma Cell Line PANC-1
In PANC-1 human pancreatic cancer cells, scientists showed that PGE2 stimulated mammalian target of rapamycin complex 1 (mTORC1) activity independently of Akt, as evaluated by downstream signaling events. [Am J Physiol Cell Physiol] Abstract

Characterization of Novel Carcinoma Cell Lines for the Analysis of Therapeutical Strategies Fighting Pancreatic Cancer
The murine pancreatic adenocarcinoma cell lines 6606PDA and 7265PDA were compared to the 6606l cell line isolated from a liver metastasis from mice suffering from pancreatic cancer. In tissue culture 6606PDA and 6606l proliferated faster than 7265PDA. [Cell Biosci] Full Article

PEBP4 Promoted the Growth and Migration of Cancer Cells in Pancreatic Ductal Adenocarcinoma
Investigators found that the messenger RNA and protein level of phosphatidylethanolamine-binding protein 4 (PEBP4) was elevated in pancreatic ductal adenocarcinoma (PDAC) samples. Forced expression of PEBP4 in PDAC cell lines promoted cell growth and migration, while downregulation of PEBP4 in PDAC cells by RNA interference (RNAi) inhibited the growth, migration, and metastasis of the cancer cells. [Tumour Biol] Abstract

Effects of Cerulein on Keratin 8 Phosphorylation and Perinuclear Reorganization in Pancreatic Cancer Cells: Involvement of Downregulation of Protein Phosphatase 2A and Alpha4
Researchers found that cerulein dose-dependently induced keratin 8 phosphorylation and perinuclear reorganization in PANC-1 cells, thus leading to migration and invasion. [Environ Toxicol] Abstract

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REVIEWS
Pax4 Acts as a Key Player in Pancreas Development and Plasticity
Comparative analysis of Pax4 and Arx mutants, as well as Arx/Pax4 double mutants, showed that islet subtype destiny is mainly directed by cross-repression of the Pax4 and Arx factors. Importantly, the ectopic expression of Pax4 in α-cells was found sufficient to induce their neogenesis and conversion into β-like cells, not only during development but also in adult rodents. [Semin Cell Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
SCIENCE NEWS
MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted in Five Separate Presentations
MabVax Therapeutics Holdings, Inc. announced that the company’s lead antibody, HuMab 5B1, will be garnering major attention as the subject of five separate presentations. Researchers from the Department of Radiology at Memorial Sloan Kettering Cancer Center will present results on the use of MabVax’s lead antibody as a PET imaging agent and as a radioimmunotherapy agent targeting pancreatic cancer. [Press release from MabVax Therapeutics Holdings, Inc. discussing research to be presented at the World Molecular Imaging Congress (WMIC), Honolulu ] Press Release

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INDUSTRY NEWS
OncoMed Pharmaceuticals Completes Enrollment of Phase II ALPINE Clinical Trial of Tarextumab in Pancreatic Cancer
OncoMed Pharmaceuticals Inc. announced that it has completed patient enrollment in its Phase II “ALPINE” clinical trial of tarextumab for the treatment of pancreatic cancer more than eight months ahead of schedule. [OncoMed Pharmaceuticals Inc.] Press Release

Novo Nordisk to Initiate Phase IIIa Development of Oral Semaglutide, a Once-Daily Oral GLP-1 Analogue
Novo Nordisk announced the decision to initiate a Phase IIIa programme with oral semaglutide; a once-daily oral formulation of the long-acting GLP-1 analogue semaglutide. [Novo Nordisk A/S] Press Release

U.S. FDA Approves Synjardy® (Empagliflozin/Metformin Hydrochloride) Tablets for Adults with Type 2 Diabetes
The U.S. Food and Drug Administration (FDA) has approved Synjardy® tablets, from Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company, for the treatment of adults with type 2 diabetes. [Eli Lilly and Company] Press Release

NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science
The National Institutes of Health (NIH) has awarded the University of Alabama at Birmingham (UAB) Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research. [University of Alabama at Birmingham] Press Release

Immatics and MD Anderson Announce Launch of Immatics US, Inc., to Develop Multiple T-Cell and TCR-Based Adoptive Cellular Therapies
Immatics Biotechnologies GmbH and The University of Texas MD Anderson Cancer Center announced the launch of Immatics US, Inc., a new company aiming at becoming a global leader in adoptive cellular therapies for the treatment of a range of tumor types. [The University of Texas MD Anderson Cancer Center] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW European Molecular Biology Laboratory (EMBL) Conference: Cancer Genomics
November 1-4, 2015
Heidelberg, Germany

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Diabetes Research (Inserm)

NEW Postdoctoral Position – Diabetes Research (Albert Einstein College of Medicine of Yeshiva University)

NEW Postdoctoral Research Fellow – Translational Research Program (Fred Hutchinson Cancer Research Center)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Research Scientist – Pancreatic Cancer (Columbia University)

Clinical Lecturer (University of Bristol)

Postdoctoral Position – Metabolic Diseases (ETH Zürich)

Postdoctoral Research Fellow – Development and Pathogenesis of Pancreatic Cancer (University College London)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)


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