Volume 6.31 | Aug 11

Pancreatic Cell News 6.31 August 11, 2015
Pancreatic Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Bacteria that Prevent Type 1 Diabetes
Researchers have recently shown how microbiota protects against the development of type 1 diabetes. They focused on a category of antimicrobial peptides, i.e. cathelicidins and hypothesized that cathelicidins may be involved in the control of type 1 diabetes. [Press release from INSERM discussing online prepublication Immunity] Press Release | Abstract | Graphical Abstract
Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells
Researchers evaluated whether TYK2 plays a role in human pancreatic β-cell apoptosis and production of pro-inflammatory mediators. TYK2-silenced human β-cells exposed to polyinosinic-polycitidilic acid showed less type I interferon (IFN) pathway activation and lower production of IFNα and CXCL10. These cells had also decreased expression of MHC class I proteins, a hallmark of early β-cell inflammation in type 1 diabetes. [Diabetes] Abstract

c-Kit Receptor Signaling Regulates Islet Vasculature, β-Cell Survival and Function In Vivo
Investigators examined the effects of c-Kit–mediated vascular endothelial growth factor isoform A (VEGF-A) and islet vascularization on β-cell function and survival using in vitro cell culture and in vivo mouse models. [Diabetes] Abstract

Adult Human Biliary Tree Stem Cells Differentiate to β-Pancreatic Islet Cells by Treatment with a Recombinant Human Pdx1 Peptide
Researchers explored a protein-based strategy to induce differentiation of human biliary tree stem cells towards β-pancreatic cells. Differentiation toward pancreatic islet cells were evaluated by the expression of the β-cell transcription factors, pancreatic and duodenal homeobox 1 (pdx1) and musculoapo-neurotic fibrosarcoma oncogene homolog A, and of the pancreatic hormones, insulin, glucagon, and somatostatin. [PLoS One] Full Article

PANCREATIC CANCER

IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer
Scientists developed IGF1 receptor (IGF1R) directed, multi-functional theranostic nanoparticles for targeted delivery of therapeutic agents into IGF1R expressing drug resistant tumor cells and tumor associated stromal cells. IGF1R targeted therapy using the theranostic IGF1-iron oxide nanoparticles-doxorubicin significantly inhibited the growth of pancreatic patient-derived xenograft tumors. [ACS Nano] Abstract

The Mek1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Protein Levels of Ribonucleotide Reductase Subunit-1 (RRM1)
Synergistic activity was observed when gemcitabine was combined sequentially with pimasertib in human pancreatic cancer cells. In particular, pimasertib reduced RRM1 protein and this was associated with sensitivity to gemcitabine. [Clin Cancer Res] Abstract

Semaphorin 3D Autocrine Signaling Mediates the Metastatic Role of Annexin A2 in Pancreatic Cancer
Using cells from a genetic mouse model of pancreatic ductal adenocarcinoma (PDA), researchers found that annexin A2 increased the release of semaphorin 3D from PDA cells and promoted migratory behavior in cultured PDA cells. [Sci Signal] Abstract | Press Release

The Pseudokinase SgK223 Promotes Invasion of Pancreatic Ductal Epithelial Cells through JAK1/Stat3 Signaling
Elevated site-selective tyrosine phosphorylation of SgK223 was identified in subsets of pancreatic ductal adenocarcinoma (PDAC) cell lines, and increased expression of SgK223 detected in several PDAC cell lines compared to human pancreatic ductal epithelial cells and in PDACs compared to normal pancreas. [Mol Cancer] Full Article

Hypoxia Inducible Factor 1α Down Regulates Cell Surface Expression of α1,2-Fucosylated Glycans in Human Pancreatic Adenocarcinoma Cells
Researchers showed that hypoxia inducible factor 1α is constitutively expressed in the pancreatic cancer cell lines Pa-Tu-8988S and Pa-Tu-8988T and suppresses the expression of the α1,2-fucosyltransferase genes FUT1 and FUT2. [FEBS Lett] Abstract

Take the &quote;if&quote; out of &quote;diff&quote;: reduce variability when differentiating to definitive endoderm.
 
REVIEWS
Process of Hepatic Metastasis from Pancreatic Cancer: Biology with Clinical Significance
The authors provide a full understanding of the hepatic metastatic process from circulating pancreatic cancer cells to their settlement in the liver, serving as a basic theory for efficient prediction and treatment of metastatic diseases. [J Cancer Res Clin Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
Sanofi and Evotec Align Forces to Develop Next Generation Therapies in Diabetes
Evotec AG and Sanofi announced a strategic collaboration in the field of diabetes. The goal of this collaboration will be to develop a beta cell replacement therapy based on functional human beta cells derived from human stem cells. [Evotec AG] Press Release

UCSF to Study Halozyme PEGPH20 in Pancreatic Cancer Patients Who Are Candidates for Potentially Curative Surgery
Halozyme Therapeutics, Inc. announced the Pancreas Center at the University of California, San Francisco (UCSF) has initiated a clinical research study of Halozyme’s investigational new drug, PEGPH20 in pancreatic cancer patients who are candidates for potentially curative surgery. [Halozyme Therapeutics, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cells: From Robert Hooke to Cell Therapy – A 350 Year Journey
October 5-6, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Development and Pathogenesis of Pancreatic Cancer (University College London)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

PhD Position – Beta-Cell Biology and Diabetes (University of British Columbia)

Postdoctoral Research Assistant – Islet Cell Electrophysiology in Diabetes Research (University of Oxford)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Research Scientist – Disease Gene Regulation (Wellcome Trust Centre for Human Genetics)

Postdoctoral Fellowship – Pancreatic Beta Cell Biology and Regeneration, Relating to Diabetes (Mount Sinai School of Medicine)

Postdoctoral Fellowship – Immunopathogenesis of Type 1 Diabetes (Tongji Medical College)

PhD Student – Diabetes (Danish Diabetes Academy)


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