Pax4 Expression Does Not Transduce Pancreatic Alpha Cells to Beta Cells
The authors generated an adeno-associated virus carrying Pax4 and GFP under a CMV promoter (AAV-Pax4). They used AAV-Pax4 to transduce a mouse alpha cell line in vitro, and to transduce primary alpha cells in diabetic mice. [Cell Physiol Biochem] Abstract
Alefacept Helps Preserve Function of Insulin-Producing Cells in Type 1 Diabetes
Results from a clinical trial sponsored by the National Institute of Allergy and Infectious Diseases suggest that the immune-suppressing drug alefacept helps preserve function of insulin-producing beta cells in people with newly diagnosed type 1 diabetes. [National Institute of Allergy and Infectious Diseases] Press Release
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