Volume 6.24 | Jun 23

Pancreatic Cell News 6.24 June 23, 2015
Pancreatic Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Drug Approved to Treat Osteoporosis Shows Promise in Pre-Clinical Diabetes Research
Scientists have discovered that a drug commonly used to treat osteoporosis in humans also stimulates the production of cells that control insulin balance in diabetic mice. While other compounds have been shown to have this effect, the drug (Denosumab) is already FDA approved and could more quickly move to clinical trials as a diabetes treatment. [Press release from Icahn School of Medicine at Mount Sinai (EurekAlert!) discussing online prepublication in Cell Metabolism] Press Release | Abstract | Graphical Abstract
Differentiation Doesn't Have to be Difficult - Get Easy, Standardized hPSC Differentiation
 
PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

DNA Methylation Directs Functional Maturation of Pancreatic β Cells
DNA methyltransferase (DNMT3A) bound to the promoters of the genes encoding hexokinase 1 and lactate dehydrogenase A—both of which regulate the metabolic switch—and knockdown of these two key DNMT3A targets restored the glucose-stimulated insulin secretion response in islets from animals with β cell-specific Dnmt3a deletion. [J Clin Invest] Full Article

Islet Amyloid Inhibitors Improve Glucose Homeostasis in a Transgenic Mouse Model of Type 2 Diabetes
To assess its activity in vivo, D-ANFLVH was administered by intraperitoneal injection into a human islet amyloid polypeptide transgenic mouse model, which replicates type 2 diabetes islet amyloid pathology. The peptide was a potent inhibitor of islet amyloid deposition, resulting in reduced islet cell apoptosis and preservation of beta cell area leading to improved glucose tolerance. [Diabetes Obes Metab] Abstract

Nitric Oxide Stress and Activation of AMP-Activated Protein Kinase Impair β-Cell Sarcoendoplasmic Reticulum Calcium ATPase 2b Activity and Protein Stability
Investigators previously demonstrated loss of β-cell sarcoendoplasmic reticulum Ca2+ ATPase 2b expression under diabetic conditions. To define the mechanisms underlying this, INS-1 cells and rat islets were treated with the proinflammatory cytokine interleukin-1β combined with or without cycloheximide or actinomycin D. [Cell Death Dis] Full Article

Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity
Scientists aimed to elucidate the role of AMP-activated protein kinase (AMPK) activity during endoplasmic reticulum stress-associated pancreatic beta cell failure. MIN6 cells were loaded with 5-amino-1-β-D-ribofuranosyl-imidazole-4-​carboxamide and metformin to assess the relationship between AMPK activity and CCAAT enhancer binding protein β expression levels. [PLoS One] Full Article

PANCREATIC CANCER

Pathophysiological Role of MicroRNA-29 in Pancreatic Cancer Stroma
In an effort to understand the molecular mechanisms associated with tumor-stromal interactions, using in vitro and in vivo models and pancreatic ductal adenocarcinoma patient biopsies, researchers showed that the loss of miR-29 is a common phenomenon of activated pancreatic stellate cells/fibroblasts, the major stromal cells responsible for fibrotic stromal reaction. [Sci Rep] Full Article

Efavirenz Has the Highest Anti-Proliferative Effect of Non-Nucleoside Reverse Transcriptase Inhibitors against Pancreatic Cancer Cells
As other non-nucleoside reverse transcriptase inhibitors (NNRTIs) have not been studied so far, all clinically used NNRTIs were tested and the in vitro toxic concentrations were compared to drug levels in patients to predict possible anti-cancer effects in vivo. [PLoS One] Full Article

Targeting Pancreatic Cancer Cells by a Novel Hydroxamate-Based Histone Deacetylase (HDAC) Inhibitor ST-3595
The authors showed that ST-3595 exerted potent anti-proliferative and cytotoxic activities against both established pancreatic cancer cell lines, and patient-derived primary cancer cells. [Tumor Biol] Abstract

Color-Coding Cancer and Stromal Cells with Genetic Reporters in a Patient-Derived Orthotopic Xenograft (PDOX) Model of Pancreatic Cancer Enhances Fluorescence-Guided Surgery
Researchers used genetic reporters to color code cancer and stroma cells in a PDOX model. The telomerase-dependent green fluorescent protein-containing adenovirus OBP-401 was used to label the cancer cells of a pancreatic cancer PDOX. [Cancer Gene Ther] Abstract

mTeSR™1: Most Published Feeder-Free hPSC Maintenance Medium. Click to View Top Applications
 
REVIEWS
Role of Parathyroid Hormone-Related Protein Signaling in Chronic Pancreatitis
Chronic pancreatitis (CP), a progressive inflammatory disease where acini are destroyed and replaced by fibrous tissue, increases the risk for pancreatic cancer. Risk factors include alcohol, smoking, and obesity. Critical questions still need to be answered to understand what modifies predisposition to develop CP in persons exposed to risk factors. [Cancers] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
ERYTECH Announces Two Positive DSMB Reviews
ERYTECH Pharma announced positive safety reviews after the completion of the first cohort in the company’s US Phase I study with ERY-ASP in Acute Lymphoblastic Leukemia (ALL), and following the treatment of the first three patients with ERY-ASP in combination with Folfox in its Phase II study in pancreatic cancer. [ERYTECH Pharma] Press Release

Resverlogix Officially Attains Phase III Status with a European Regulatory Authority
Resverlogix Corp. announced that following recent meetings with various European regulatory bodies, the first confirmation for their Phase III clinical plan has officially been received. A further regulatory and protocol design update will be provided to the market post the approval of additional regulatory bodies and the launch of the planned Phase III clinical trial entitled BETonMACE. [Resverlogix Corp.] Press Release

Insulin Independence Revolutionary Phase III Trial
Perle Bioscience, Inc. announced enrollment for the Insulin Independence Trial. This trial is the first Phase III trial to test a combination therapy in type 1 diabetics. [Perle Bioscience, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW UMIB Summit 2015® – Multidisciplinary Scientific Meeting
September 24-25, 2015
Porto, Portugal

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW PhD Student – Diabetes (Danish Diabetes Academy)

NEW Research Associate – Cancer Therapeutics (University of Cambridge)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Adipocyte Development (German Institute of Human Nutrition)

Postdoctoral Research Associate – Type 1 Diabetes and Other Autoimmune Diseases (Benaroya Research Institute at Virginia Mason)

PhD Position – Pancreatic Diseases (University Hospital Zurich)

Postdoctoral Position – Metabolic Fingerprinting of Gestational Diabetes Mellitus (CEU San Pablo University)

Postdoctoral Position – Cancer (MD Anderson Cancer Center)

PhD Studentships – Diabetes Research (Diabetes UK)


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