Volume 6.23 | Jun 16

Pancreatic Cell News 6.23 June 16, 2015
Pancreatic Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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“Crosstalk” Gives Clues to Diabetes
Scientists have identified a key part of the conversation going on between cells in the pancreas. A hormone called urocortin 3, they found, is released at the same time as insulin and acts to damp down insulin production. [Press release from UC Davis discussing online prepublication in Nature Medicine] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

S6K1 Controls Pancreatic β Cell Size Independently of Intrauterine Growth Restriction
Investigators found that S6K1 deficiency in mice also leads to decreased β cell growth, intrauterine growth restriction, and impaired placental development. [J Clin Invest] Full Article

High-Fat Diet Increases Autophagic Flux in Pancreatic Beta Cells In Vivo and Ex Vivo in Mice
Investigators determined the effects of high-fat feeding on true autophagic flux in beta cells in vivo in mice, and established the relationship between autophagy, endoplasmic reticulum stress and apoptosis. [Diabetologia] Abstract

Bile Acid Effects Are Mediated by ATP Release and Purinergic Signaling in Exocrine Pancreatic Cells
Scientists aimed to elucidate whether there is interplay between ATP and bile acid signaling. They showed that chenodeoxycholic acid caused fast and concentration-dependent ATP release from acini and duct cells. [Cell Commun Signal] Full Article

A Northern Contaminant Mixture Impairs Pancreas Function in Obese and Lean JCR Rats and Inhibits Insulin Secretion in MIN6 Cells
Studies conducted with cultured mouse insulin-secreting MIN6 cells demonstrated that Northern contaminant mixture (NCM) inhibited insulin release and induced cell death through oxidative stress and mitochondrial dysfunction. 2,3,4,6-Tetrabromophenol, a minor component of the NCM, alone also inhibited insulin release from MIN6 cells after 10 minutes of exposure. [Toxicology] Abstract

Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis
The authors investigated whether sesamin protects against advanced glycation end products-evoked β-cell damage via its antioxidant property. The effects of sesamin were examined in C57BL/6J mice and MIN6 cell line. [Nutrients] Abstract | Download Full Article


FoxO1-Negative Cells Are Cancer Stem-Like Cells in Pancreatic Ductal Adenocarcinoma
Researchers reported evidence of FoxO1-negative pancreatic ductal adenocarcinoma (PDAC) cells as cancer stem cells in PDAC. Both aldehyde dehydrogenase-high and CD133-high cell fractions isolated from PDAC of the patients expressed high levels of miR-21 and null FoxO1. [Sci Rep] Full Article

ROBO3 Promotes Growth and Metastasis of Pancreatic Carcinoma
Scientists showed that ROBO3 expression is up-regulated in pancreatic cancer tissue samples and cell lines. Over-expression of ROBO3 promotes pancreatic cancer cell growth, invasion and metastasis in vitro and in mouse xenograft tumor models. [Cancer Lett] Abstract

MicroRNA-153 Is a Prognostic Marker and Inhibits Cell Migration and Invasion by Targeting SNAI1 in Human Pancreatic Ductal Adenocarcinoma
Researchers investigated the expression levels of microRNA (miR)-153 using RT-qPCR in human pancreatic ductal adenocarcinoma (PDAC) cell lines and tissues. They showed that the relative expression of miR-153 in PDAC cells was obviously decreased as compared to that in the normal human pancreatic duct epithelial cell line. [Oncol Rep] Abstract

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A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes
The authors focus on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. They also explain the possible metabolic relation and association between the two diseases. [Mol Cells] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
New Details Emerge from JDRF-Supported Islet Cell Encapsulation Research
JDRF’s work to accelerate development of encapsulated islet cell therapies for treatment of type 1 diabetes was on display as three investigators funded by the organization presented new details from their recently published works. [Press release from JDRF discussing research presented at the 2015 American Diabetes Association (ADA) Scientific Sessions, Boston] Press Release

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Johnson & Johnson Innovation Announces 17 Collaborations with Focus on Advancing Global Healthcare through Transformational Science and Technologies
Johnson & Johnson Innovation announced 17 new collaborations with research institutions and healthcare companies. The announcement includes the first alliance for the Disease Interception Accelerator, a research agreement with Washington University to identify the root cause of type 1 diabetes and enable the development of interventions that halt progression to disease. [Johnson & Johnson Innovation] Press Release

STEMCELL Technologies Named Company of the Year by BIOTECanada
STEMCELL Technologies Inc. was presented with the Biotech Company of the Year award by BIOTECanada at this year’s BIO International Convention in Philadelphia. [BIOTECanada] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2nd International Symposium of the Cancer Research Center of Lyon (CRCL)
September 21-23, 2015
Lyon, France

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Position – Adipocyte Development (German Institute of Human Nutrition)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Associate – Type 1 Diabetes and Other Autoimmune Diseases (Benaroya Research Institute at Virginia Mason)

PhD Position – Pancreatic Diseases (University Hospital Zurich)

Postdoctoral Position – Metabolic Fingerprinting of Gestational Diabetes Mellitus (CEU San Pablo University)

Postdoctoral Position – Cancer (MD Anderson Cancer Center)

Research Fellow – Systems Biology (University of Glasgow)

PhD Studentships – Diabetes Research (Diabetes UK)

Postdoctoral Position – Obesity and Diabetes Research (University of Iowa)

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