Volume 6.16 | Apr 28

Pancreatic Cell News 6.16 April 28, 2015
Pancreatic Cell News
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Researchers Develop Novel Technique to Generate Functional, Insulin-Producing Beta-Like Cells
Researchers identified a novel technique for transforming human embryonic stem cells into insulin-producing cells. [Press release from UCSF discussing online prepublication in The EMBO Journal]
Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

TEAD and YAP Regulate the Enhancer Network of Human Embryonic Pancreatic Progenitors
Using human embryonic pancreas and embryonic-stem-cell-derived progenitors researchers identified stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. [Nat Cell Biol] Abstract

Long-Term High-Fat High-Sucrose Diet Promotes Enlarged Islets and β-Cell Damage by Oxidative Stress in Bama Minipigs
The authors investigated the pancreatic histopathology and β-cell apoptosis in Bama minipigs after 23 months on a high-fat high-sucrose diet. [Pancreas] Full Article

Polyphenols Isolated from Broussonetia kazinoki Prevent Cytokine-Induced β-Cell Damage and the Development of Type 1 Diabetes
Researchers investigated the effects of kazinol C and isokazinol D isolated from B. kazinoki on the β-cell viability and function. RINm5F cells and primary islets were used for in vitro and ex vivo cytokine toxicity experiments, respectively. [Exp Mol Med] Full Article


Next-Generation Sequencing Reveals Novel Differentially Regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in Pancreatic Cancer
The authors analyzed the coding and non-coding transcriptome of six pancreatic cancer and five control tissues using next-generation sequencing. Overexpression of microRNA (miR)-802 in MiaPaCa pancreatic cancer cells reduced TCF4 protein levels. [Mol Cancer] Abstract | Full Article

Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells
Scientists present a novel oligonucleotide chimera, composed by an RNA aptamer and a DNA decoy. The assembly is able to target tumor cells via an antitransferrin receptor RNA aptamer and perform selective codelivery of a chemotherapeutic drug and of an inhibitor of a cell-survival factor, the nuclear factor κB decoy oligonucleotide. [Mol Ther Nucleic Acids] Full Article

Deregulation of the miR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer
Researchers identified microRNA (miR)-193b as a tumor-suppressive miRNA in pancreatic ductal adenocarcinoma (PDAC). Expression analyses revealed that miR-193b was downregulated in PDAC specimens and cell lines. [PLoS One] Full Article

Annexin V-Directed Enzyme Prodrug Therapy plus Docetaxel for the Targeted Treatment of Pancreatic Cancer
The binding strength of fusion proteins to the human pancreatic cancer (PDAC) cell lines Panc-1 and Capan-1 was measured via streptavidin-horseradish peroxidase binding to biotinylated fusion proteins. All fusion proteins exhibited strong binding to PDAC cells, with dissociation constants between 0.02 and 1.15 nM. [Pancreas] Abstract

The Influence of SnoN Gene Silencing by siRNA on the Cell Proliferation and Apoptosis of Human Pancreatic Cancer Cells
Investigators revealed that the RNAi-mediated downregulation of SnoN effectively inhibited the proliferation of pancreatic cancer (PC) cells. SnoN-siRNA also enhanced SW1990 PC cell apoptosis. [Diagn Pathol] Full Article

Effects of Emodin on the Demethylation of Tumor-Suppressor Genes in Pancreatic Cancer PANC-1 Cells
Researchers hypothesized that emodin exerts its antitumor effect by participating in the regulation of the DNA methylation level. Researchers showed that emodin inhibited the growth of pancreatic cancer PANC-1 cells in a dose- and time-dependent manner. [Oncol Rep] Abstract

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Emerging Treatments for Post-Transplantation Diabetes Mellitus
The authors outline the modern principles of glucose-lowering treatment in post-transplantation diabetes mellitus with specific reference to renal transplant recipients. [Nat Rev Nephrol] Abstract

New Insights Into the Role of Macrophages in β-Cell Proliferation
The authors discuss several independent studies, using different regeneration models, that demonstrate a substantial inductive role for macrophages in β-cell proliferation. Additional dissection of the involved cell-cell crosstalk through specific signal transduction pathways is expected to improve the understanding of β-cell proliferation and might facilitate the current β-cell replacement therapy. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Target Cancer Metabolism
Cancer Treatment Centers of America at Western Regional Medical Center Launches Phase II of Innovative ‘PembroPlus’ Clinical Trial
Cancer Treatment Centers of America® at Western Regional Medical Center has begun the Phase II portion of the first of six arms of this first-of-its-kind clinical trial, using a new immunotherapy treatment for patients with advanced small cell lung cancer, pancreatic cancer and connective-tissue cancers, including breast cancer. [Cancer Treatment Centers of America, Inc.] Press Release

Merrimack Pharmaceuticals and Baxter BioScience Announce Completion of New Drug Application Submission to U.S. FDA for MM-398 as a Treatment for Post-Gemcitabine Metastatic Pancreatic Cancer
Merrimack Pharmaceuticals, Inc. and Baxter International Inc. jointly announced that Merrimack has completed the rolling submission of the new drug application for MM-398, also known as “nal-IRI,” to the U.S. Food and Drug Administration (FDA). Merrimack is seeking U.S. marketing approval of MM-398 for the treatment of patients with metastatic adenocarcinoma of the pancreas who have been previously treated with gemcitabine-based therapy. [Merrimack Pharmaceuticals, Inc.] Press Release

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NEW Cells: From Robert Hooke to Cell Therapy – A 350 Year Journey
October 5-6, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Position – Obesity and Diabetes Research (University of Iowa)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technician – Diabetes (University of Oxford)

Postdoctoral Research Fellow – Mechanisms of Cell Death of Normal Tissue Stem Cells (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Image-Guided Drug Delivery (Eindhoven University of Technology)

Research Assistant Professor – Protein Misfolding and Toxicity (George Washington University)

Director – Center of Emphasis in Diabetes and Metabolism (Texas Tech University Health Sciences Center)

Postdoctoral Position – Obesity & Diabetes (INSERM U892)

Postdoctoral Positions – Developmental Biology (Joslin Diabetes Center)

Postdoctoral Fellow – Type 2 Diabetes (Harvard Medical School)

Tenure-Track Immunology Faculty Position – Diabetes (University of Connecticut Health Center)

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