Volume 6.01 | Jan 13

Pancreatic Cell News 6.01 January 13, 2015
Pancreatic Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  PACN on Twitter
 
TOP STORY
Loss of FFA2 and FFA3 Increases Insulin Secretion and Improves Glucose Tolerance in Type 2 Diabetes
Scientists demonstrate that the short-chain fatty acid receptors FFA2 and FFA3 are expressed in mouse and human pancreatic beta cells and mediate an inhibition of insulin secretion by coupling to Gi-type G proteins. [Nat Med] Abstract
Request a Sample: ReproTeSR™
 
PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function
Researchers report a luminescent insulin secretion assay that enables large-scale investigations of beta-cell function, created by inserting Gaussia luciferase into the C-peptide portion of proinsulin. [Cell Metab]
Abstract | Graphical Abstract

Phosphorylation of Caveolin-1 on Tyrosine-14 Induced by ROS Enhances Palmitate-Induced Death of Beta-Pancreatic Cells
Researchers tested whether the presence of caveolin-1 modulates free fatty acid-induced beta cell death by reexpressing this protein in MIN6 murine beta cells lacking caveolin-1. Incubation of MIN6 with palmitate, but not oleate, induced apoptotic cell death that was enhanced by the presence of caveolin-1. [Biochim Biophys Acta] Abstract

TRPM2 Mediated Intracellular Zn2+ Release Triggers Pancreatic Beta Cell Death
Given Zn2+ is cytotoxic, scientists asked if transient receptor potential (melastatin)2 (TRPM2) channels can permeate sufficient Zn2+ to affect cell viability. To address this, they used the INS1 β-cell line, HEK-293 cells transfected with TRPM2 and pancreatic islets. [Biochem J] Abstract

Cyclin C Stimulates Beta-Cell Proliferation in Rat and Human Pancreatic Beta-Cells
Scientists hypothesized that cyclin C overexpression would induce beta-cell proliferation through G0 exit, thus being a potential therapeutic target to recover functional beta-cell mass. [Am J Physiol Endocrinol Metab] Abstract

PANCREATIC CANCER

A Novel CDC25B Promoter Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models
Scientists investigated the in vitro lytic effect and the in vivo therapeutic efficacy in combination with gemcitabine, on human pancreatic tumor xenografts orthotopically growing in nude mice, and in tumors growing in Syrian hamsters. AV25CDC exhibited a strong in vitro lytic effect on pancreatic cancer cells. [Clin Cancer Res] Abstract

Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Pro-Survival Autophagic Signals in Human Pancreatic Cancer Cells
Researchers show that GSK3 inhibition induces pro-survival signals through increased activity of the autophagy/lysosomal network. Data also revealed a contribution of GSK3 in the regulation of the master transcriptional regulator of autophagy and lysosomal biogenesis, transcription factor EB in pancreatic cancer cells. [J Biol Chem] Abstract | Full Article

CD44 Regulates Pancreatic Cancer Invasion through MT1-MMP
Using both in vitro and in vivo approaches, investigators demonstrated that CD44, a transmembrane glycoprotein expressed on a subset of pancreatic cancer cells, is required for the induction of epithelial-mesenchymal transition and the activation of an invasive program in pancreatic cancer. [Mol Cancer Res] Abstract

Epigenetic Regulation of the lncRNA MEG3 and Its Target c-MET in Pancreatic Neuroendocrine Tumors
Scientists found that Meg3 has tumor suppressor activity in pancreatic neuroendocrine tumor cells because overexpression of Meg3 in MIN6 cells blocked cell proliferation and delayed cell cycle progression. [Mol Endocrinol] Abstract

Identification of Cystatin SN as a Novel Biomarker for Pancreatic Cancer
Scientists assessed whether cystatin SN is a potential biomarker for early diagnosis of malignant pancreatic neoplasms. Microarray analysis of mRNA extracted from pancreatic cancer and pancreatic normal tissues was performed. [Tumor Biol] Abstract

Time and Concentration Dependency of P-gp, MRP1 and MRP5 Induction in Response to Gemcitabine Uptake in Capan-2 Pancreatic Cancer Cells
Researchers investigated the time course and dose dependency of the induction of three efflux proteins, P-gp, MRP1 and MRP5, in response to gemcitabine exposure in Capan-2 pancreatic cancer cell line at transcriptional and translational levels. [Xenobiotica] Abstract

Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
 
REVIEWS
The Conflicting Roles of Tumor Stroma in Pancreatic Cancer and Their Contribution to the Failure of Clinical Trials: A Systematic Review and Critical Appraisal
The authors evaluate the evidence that supports a role of the stroma in pancreatic ductal adenocarcinoma with functional experiments in relevant models, discuss the clinical trials that have aimed to target the stroma in this disease, and examine recent work that explains why these clinical trials based on stroma-targeting strategies have thus far not achieved the expected success. [Cancer Metastasis Rev] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
ViaCyte Receives Clearance from Health Canada for Diabetes Clinical Trial
ViaCyte, Inc. has received a No Objection Letter from Health Canada providing clearance to proceed with sites in Canada for the company’s Phase I/II clinical trial of its VC-01™ product candidate. [ViaCyte, Inc.]
Press Release

JDRF to Honor Scientists for Their Outstanding Work in Advancing Type 1 Diabetes Research
JDRF has selected a novel beta cell therapy research team, an immunologist, and a diabetes organ donation network and biorepository to receive its most prestigious annual recognitions during its forthcoming awards dinner. [JDRF] Press Release

The Pancreatic Cancer Action Network and the National Cancer Institute’s Frederick National Laboratory for Cancer Research Join Forces for Research Initiative
The Pancreatic Cancer Action Network and the National Cancer Institute’s Frederick National Laboratory for Cancer Research have joined together to award two fellowships to support research on KRAS mutations that are relevant to pancreatic cancer in order to improve treatment outcomes. [Pancreatic Cancer Action Network] Press Release

Novocure Announces the Completion of Enrollment of Its PANOVA Trial of Tumor Treating Fields plus Gemcitabine for Treatment of Pancreatic Cancer
Novocure announced that the last patient has been enrolled in the PANOVA trial, an open-label Phase II clinical trial of tumor treating fields together with gemcitabine in twenty patients with newly-diagnosed advanced pancreatic adenocarcinoma. [Novocure] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW CIRM 2.0 Free Webinar – Changing the Way We Work
January 21, 12:00 PM PST
Online

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Postdoctoral Fellow – Dynamics of Regulatory Genomics (IGTP)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – The Role of the Fas Pathway in Regulating Autoimmune Diabetes (Johns Hopkins University School of Medicine)

Professorship – Molecular Mechanisms of Diabetes Pathogenesis (University of Southern Denmark)

Research Technician – Diabetes, Endocrinology and Metabolism (Imperial College London)

Assistant or Associate Professor – Pediatric Diabetes and Metabolic Disease (University of California San Diego Health System)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Postdoctoral Fellowship Position – Obesity and Diabetes Pathogenesis (NIDDK / NIH)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
 

Have we missed an important article or publication in Pancreatic Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Pancreatic Cell News: Archives | Events | Contact Us