Volume 6.00 | Jan 6

Pancreatic Cell News 6.00 January 6, 2015
Pancreatic Cell News
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TOP STORY
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Investigators established organoid models from normal and neoplastic murine and human pancreas tissues. Pancreatic organoids can be rapidly generated from resected tumors and biopsies, survive cryopreservation, and exhibit ductal- and disease-stage-specific characteristics. [Cell] Abstract | Press Release
Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
 
PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death
Researchers report that exposure of β-cell lines and human pancreatic islets to high levels of glucose and lipids blocks autophagic flux and leads to apoptotic cell death. [J Biol Chem] Abstract | Full Article

Curcumin Enhances Recovery of Pancreatic Islets from Cellular Stress Induced Inflammation and Apoptosis in Diabetic Rats
Scientists explored the role of curcumin in the pancreatic tissue of STZ induced and cellular stress mediated diabetes in eight weeks old male Wistar rats. [Toxicol Appl Pharmacol] Abstract

Alanyl-Glutamine Improves Pancreatic β-Cell Function following Ex Vivo Inflammatory Challenge
Researchers studied whether the dipeptide L-Alanyl-L-Glutamine could exert protective effects via Sirtuin 1/Hur signaling in β-cells, against detrimental responses following ex vivo stimulation with inflammatory mediators-derived from macrophages. [J Endocrinol] Abstract

Carriers of Loss-of-Function Mutations in EXT Display Impaired Pancreatic Beta-Cell Reserve Due to Smaller Pancreas Volume
Scientists hypothesized that loss of function of Exotosin-1 (EXT1) or EXT2 in subjects with hereditary multiple exostoses affects pancreatic insulin secretion capacity and development. [PLoS One] Full Article

Effect of Cyclophosphamide on Expression of MMP-9 and TGF-β1 in Renal Tissue of Rats with Diabetes Mellitus
Researchers investigated the effect of cyclophosphamide on expression of matrix metalloproteinases (MMP-9) and transforming growth factor-β1 (TGF-β1) in renal tissue of rats with diabetic nephropathy. [Cell Biochem Biophys] Abstract

PANCREATIC CANCER

The Carboxyl Tail of Connexin32 Regulates Gap Junction Assembly in Human Prostate and Pancreatic Cancer Cells
Investigators explored the role of the cytoplasmic tail of Cx32, a connexin (Cx) expressed in polarized and differentiated cells, in regulating gap junction assembly. [J Biol Chem] Abstract | Full Article

Dynamic Epigenetic Regulation by Menin during Pancreatic Islet Tumor Formation
To elucidate the role of methylation of histone H3 at lysine 4 (H3K4) mediated by menin-histone methyltransferases complexes during pancreatic neuroendocrine tumor formation, genome-wide H3K4 trimethylation signals were mapped in pancreatic islets using unbiased chromatin immunoprecipitation coupled with next-generation sequencing. [Mol Cancer Res] Abstract

Increased Expression of PHD3 Represses the HIF-1 Signaling Pathway and Contributes to Poor Neovascularization in Pancreatic Ductal Adenocarcinoma
By comparing pancreatic ductal adenocarcinoma (PDAC) to hepatocellular carcinoma, which is well vascularized, scientists investigated the mechanisms and tumor biological significance of the poor neovascularization in PDAC. [J Gastroenterol] Full Article

Implications of Targeted Genomic Disruption of β-Catenin in BxPC-3 Pancreatic Adenocarcinoma Cells
To obtain more insight into the role of WNT/β-catenin signaling in pancreatic adenocarcinoma (PA) scientists established human PA cell lines that are deficient of the central canonical WNT signaling protein β-catenin by using zinc-finger nuclease mediated targeted genomic disruption in the β-catenin gene. [PLoS One] Full Article

Fucoidan from Turbinaria conoides: A Multifaceted ‘Deliverable’ to Combat Pancreatic Cancer Progression
Researchers investigated the antioxidant and anti-cancer effects of fucoidans, sulfated polysaccharides from Turbinaria conoides in pancreatic cancer cell lines. [Int J Biol Macromol] Abstract

A Bioengineered Murine Model Using CD24+CD44+ Pancreatic Cancer Stem Cells for Chemotherapy Study
CD24+CD44+ cancer stem cells successfully initiated tumorigenesis in vitro on the scaffold without suffering apoptosis, evidencing the lack of cytotoxicity of scaffolding materials. [Biomed Mater] Abstract

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REVIEWS
Natural History of β-Cell Adaptation and Failure in Type 2 Diabetes
The authors discuss the different stages that contribute to the development of β-cell failure in type 2 diabetes mellitus. They divide the natural history of this process in three major stages: susceptibility, β-cell adaptation and β-cell failure and provide an overview of the molecular mechanisms involved. [Mol Aspects Med] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
Innovate Biopharmaceuticals Acquires Late-Stage Pancreatic Imaging Assets
Innovate Biopharmaceuticals, Inc. has entered into an agreement to purchase all assets related to RG-1068, a synthetic version of human secretin from Repligen Corporation. Repligen has completed a Phase III study demonstrating that RG-1068 improved detection of pancreatic duct abnormalities in patients with known or suspected pancreatitis. [Innovate Biopharmaceuticals, Inc.] Press Release

FDA Grants Orphan Drug Designation to Nuvilex for Pancreatic Cancer Treatment
Nuvilex, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Nuvilex orphan drug designation for its pancreatic cancer treatment. Nuvilex’s pancreatic cancer treatment combines Nuvilex’s patented and proprietary cellulose-based encapsulation technology, known as Cell-in-a-Box®, with the cancer prodrug ifosfamide and encapsulated live cells that convert the prodrug into its cancer-killing form. [Nuvilex, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Gordon Research Conference: Stem Cells & Cancer
February 15-20, 2015
Ventura, United States

NEW 4th International Conference on Immunochemotherapy
April 16-17, 2015
Philadelphia, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Dynamics of Regulatory Genomics (IGTP)

NEW Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Fellow – The Role of the Fas Pathway in Regulating Autoimmune Diabetes (Johns Hopkins University School of Medicine)

NEW Professorship – Molecular Mechanisms of Diabetes Pathogenesis (University of Southern Denmark)

NEW Research Technician – Diabetes, Endocrinology and Metabolism (Imperial College London)

NEW Assistant or Associate Professor – Pediatric Diabetes and Metabolic Disease (University of California San Diego Health System)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Postdoctoral Fellowship Position – Obesity and Diabetes Pathogenesis (NIDDK / NIH)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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