The Pancreatic β Cell: Recent Insights from Human Genetics|
Studies into the genetic basis of Mendelian forms of diabetes have successfully identified genes involved in both β cell function and pancreatic development. For type 2 diabetes, genome-wide association studies are uncovering an ever-increasing number of susceptibility variants that exert their effect through β cell dysfunction, but translation to mechanistic understanding has in most cases been slow. [Trends Endocrinol Metab]
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