|PUBLICATIONS (Ranked by impact factor of the journal)|
DIABETES & PANCREATITIS|
SUMO1 Enhances cAMP-Dependent Exocytosis and Glucagon Secretion from Pancreatic α-Cells
Scientists sought to determine whether small ubiquitin‐like modifier‐1 (SUMO1) modulates mouse and human α-cell function. Action potentials, ion channel function, and exocytosis in single α-cells from mice and humans, identified by glucagon immunostaining, and glucagon secretion from intact islets were measured. [J Physiol]
The Novel GLP-1-Gastrin Dual Agonist, ZP3022, Improves Glucose Homeostasis and Increases Beta Cell Mass without Affecting Islet Number in db/db Mice
Researchers investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)-gastrin dual agonist, ZP3022, on glycemic control, beta cell mass and proliferation, and islet number. [J Pharmacol Exp Ther]
Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells
Researchers hypothesized that Ets1 plays an important role in mediating extracellular-regulated kinase 1/2 induced glucotoxicity in β-cells. They determined the role of Ets1 in Min6 cells and isolated mouse islets using overexpression and siRNA mediated knockdown of Ets1. [PLoS One]
Glucagon-Like Peptide-1 Analog-Mediated Protection against Cholesterol-Induced Apoptosis via mTOR Activation in Pancreatic βTC-6 Cells
Scientists investigated the protective effects of the glucagon-like peptide-1 analog, liraglutide, against cholesterol-induced lipotoxicity and the underlying mechanisms. [J Diabetes]
Genetic Inactivation of the Pancreatitis-Inducible Gene Nupr1 Impairs PanIN Formation by Modulating KrasG12D-Induced Senescence
Scientists found that genetic inactivation of nuclear protein 1 (Nupr1) in mice impairs Kras-induced pancreas intraepithelial neoplasias (PanIN), leading to an increase in β-galactosidase-positive cells and an upregulation of surrogate marker genes for senescence. [Cell Death Differ]
Biotin Uptake by Mouse and Human Pancreatic Beta Cells/Islets: A Regulated, Lipopolysaccharides-Sensitive Carrier-Mediated Process
Biotin uptake by pancreatic beta-TC-6 cells is adaptively regulated by extracellular substrate level. Chronic treatment of pancreatic beta-TC-6 cells with bacterial lipopolysaccharides leads to inhibition in biotin uptake. [Am J Physiol Gastrointest Liver Physiol]
Berberine Diminishes Side Population and Down-Regulates Stem Cell-Associated Genes in the Pancreatic Cancer Cell Lines PANC-1 and MIA PaCa-2
Researchers investigated the effect of berberine on pancreatic cancer stem cells of PANC-1 and MIA PaCa-2. For both cell lines, the proportions of side-population cells in the presence of berberine were investigated and compared to the proportions in the presence of gemcitabine, a standard pancreatic anti-cancer drug. [Mol Cell Biochem]
KAP-1 Is Overexpressed and Correlates with Increased Metastatic Ability and Tumorigenicity in Pancreatic Cancer
KAP-1 was found to be overexpressed in human pancreatic cancer, and the expression of KAP-1 correlated with clinical stage. Overexpression of KAP-1 increased the invasion and migration of Capan-2 cells in vitro. [Med Oncol]
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