Volume 5.19 | May 20

Pancreatic Cell News 5.19 May 20, 2014
Pancreatic Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Role of β Cell Glucagon-Like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs
Glucagon-like peptide-1 (GLP-1), an insulinotropic gut peptide released after eating, is essential for normal glucose tolerance. To determine whether this effect is mediated directly by GLP-1 receptors (GLP1R) on islet β cells, researchers developed mice with β cell-specific knockdown of Glp1r. [Cell Metab]
Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

Chronological Analysis with Fluorescent Timer Reveals Unique Features of Newly Generated β Cells
While numerous studies have uncovered the molecular mechanisms regulating pancreas development, it remains to be clarified how β cells arise from progenitors, and how recently specified β cells are different from pre-existing β cells. Scientists developed a mouse model in which the insulin 1 promoter drives DsRed-E5 “Timer” fluorescence that shifts its spectrum over time. [Diabetes] Abstract

Efficacy of Gemcitabine Conjugated and miRNA-205 Complexed Micelles for Treatment of Advanced Pancreatic Cancer
Researchers designed self-assembling, gemcitabine conjugated cationic copolymers for co-delivery of a tumor suppressor miRNA-205 and evaluated their in vivo efficacy in a pancreatic cancer ectopic tumor model developed using gemcitabine resistant MIA PaCa-2R cells. [Biomaterials] Abstract

TRB3 Is Involved in Free Fatty Acid-Induced INS-1-Derived Cell Apoptosis via the Protein Kinase C δ Pathway
Researchers outlined the role of tribbles homolog 3 (TRB3) in free fatty acids (FFAs)-induced INS-1 β cell apoptosis. TRB3 was promptly induced in INS-1 cells after stimulation by FFAs, and this was accompanied by enhanced INS-1 cell apoptosis. [PLoS One] Full Article

Puerarin Protects Pancreatic β-Cell Survival via PI3K/Akt Signaling Pathway
Scientists investigated the effect of puerarin on pancreatic β-cell survival and function. In cultured islets and MIN6 cells, puerarin protected β-cell from cobalt chloride-induced apoptosis, and restored the impaired capacity of glucose stimulated insulin secretion. [J Mol Endocrinol] Abstract

PANCREATIC CANCER

Gemcitabine and Chk1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma
The combination of gemcitabine and Chk1 inhibitor PF-477736 with 177Lu-anti-EGFR antibody was tolerated in mice. This triplet was effective in established tumors and prevented the recurrence of pancreatic ductal adenocarcinoma in four cell-line derived and one patient-derived xenograft models. [Clin Cancer Res] Abstract

PRIMA-1, a Mutant p53 Reactivator, Induces Apoptosis and Enhances Chemotherapeutic Cytotoxicity in Pancreatic Cancer Cell Lines
Scientists investigated the effects of p53 reactivation and induction of massive apoptosis (PRIMA-1) on cell viability, cell cycle and expression of p53-regulated proteins in PANC-1 and BxPC-3, and CAPAN-2 pancreatic cell lines. [Invest New Drugs] Abstract

Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (ADP-Ribose) Polymerase Inhibition with ABT-888
Scientists determined whether poly (ADP-ribose) polymerase-1/2 inhibition enhances radiation-induced cytotoxicity of pancreatic adenocarcinoma in vitro and in vivo, and the mechanism by which this occurs. [Transl Oncol] Full Article

Pancreatic Tumor Cell Secreted CCN1/Cyr61 Promotes Endothelial Cell Migration and Aberrant Neovascularization
In vitro and in vivo models show that pancreatic cancer cell generated unique microenvironments can underlie endothelial cell migration and tumor angiogenesis. [Sci Rep] Full Article

Take the "if" out of "diff": Reduce variability when differentiating to endothelial cells
 
REVIEWS
Revealing Transcription Factors during Human Pancreatic β Cell Development
The authors present current knowledge of developing human β cell transcription factor expression, as compared to rodents. They also discuss recent studies employing transcription factor or epigenetic modulation to generate β cells. [Trends Endocrinol Metab] Abstract

Skin Deep: From Dermal Fibroblasts to Pancreatic Beta Cells
Researchers discuss a novel 3D platform for the generation of highly efficient human insulin-producing cells. [Immunol Res] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
Orbsen Therapeutics Cell Therapy Selected for Diabetic Wound Clinical Trial Led by NUI Galway and Steno Diabetes Center
Orbsen Therapeutics proprietary stromal cell therapy has been selected to be tested in a EU Framework 7 funded safety trial for the treatment of non-healing, ulcerating wounds in patients with diabetes. [Orbsen Therapeutics] Press Release

Bold Initiative to Transform Cancer Care Established with a $100 Million Gift
Memorial Sloan Kettering Cancer Center announced the creation of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology (CMO). Named in honor of Marie-Josée and Henry R. Kravis and the $100 million gift from their foundation, the CMO will enable researchers to speed the translation of new discoveries into routine clinical practice and reshape the design of clinical trials. [Memorial Sloan Kettering Cancer Center]
Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Case Western Reserve University (CWRU): National Center for Regenerative Medicine Cancer Stem Cell Conference
August 17-20, 2014
Cleveland, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Role of Calreticulin in TGF-Beta Signaling in the Kidney Proximal Tubule under Diabetic Conditions (University of Alabama)

NEW Clinical Senior Lecturer in Diabetes (Queen’s University Belfast)

Staff Scientist and Postdoctoral Positions – Beta Cell Biology and Diabetes Research (Sanford Research / USD)

Postdoctoral Fellowship – Diabetes (Lund University Diabetes Center)

Postdoctoral Position – Pancreatic Cancer (CNIO – Spanish National Cancer Research Center)

Associate Academic Staff – Diagnosis, Prevention and Treatment of Diabetes (Vrije Universiteit Brussel)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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