Chronological Analysis with Fluorescent Timer Reveals Unique Features of Newly Generated β Cells
While numerous studies have uncovered the molecular mechanisms regulating pancreas development, it remains to be clarified how β cells arise from progenitors, and how recently specified β cells are different from pre-existing β cells. Scientists developed a mouse model in which the insulin 1 promoter drives DsRed-E5 “Timer” fluorescence that shifts its spectrum over time. [Diabetes]
Abstract
Puerarin Protects Pancreatic β-Cell Survival via PI3K/Akt Signaling Pathway
Scientists investigated the effect of puerarin on pancreatic β-cell survival and function. In cultured islets and MIN6 cells, puerarin protected β-cell from cobalt chloride-induced apoptosis, and restored the impaired capacity of glucose stimulated insulin secretion. [J Mol Endocrinol]
Abstract
Revealing Transcription Factors during Human Pancreatic β Cell Development
The authors present current knowledge of developing human β cell transcription factor expression, as compared to rodents. They also discuss recent studies employing transcription factor or epigenetic modulation to generate β cells. [Trends Endocrinol Metab]
Abstract
Bold Initiative to Transform Cancer Care Established with a $100 Million Gift
Memorial Sloan Kettering Cancer Center announced the creation of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology (CMO). Named in honor of Marie-Josée and Henry R. Kravis and the $100 million gift from their foundation, the CMO will enable researchers to speed the translation of new discoveries into routine clinical practice and reshape the design of clinical trials. [Memorial Sloan Kettering Cancer Center] Press Release
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