Volume 5.18 | May 13

Pancreatic Cell News 5.18 May 13, 2014
Pancreatic Cell News
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Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia
Using a murine model of pancreatic intraepithelial neoplasia (PanIN), scientists found that KrasG12D induces expression of functional IL-17 receptors on PanIN epithelial cells and also stimulates infiltration of the pancreatic stroma by IL-17-producing immune cells. [Cancer Cell] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Blockade of Na+ Channels in Pancreatic α-Cells Has Anti-Diabetic Effects
Researchers tested the hypothesis that ranolazine exerts its anti-diabetic effects by inhibiting glucagon release via blockade of Na+ channels (NaChs) in the pancreatic α-cells. They showed that ranolazine, via blockade of NaChs in pancreatic α-cells, inhibits their electrical activity and reduces glucagon release. [Diabetes] Abstract

A Nanocarrier System for the Delivery of Nucleic Acids Targeted to a Pancreatic Beta Cell Line
Researchers report on a liposome-based carrier targeted to pancreatic β cells (Multifunctional envelope-type nano device for pancreatic β cells, β-MEND). They identified a lipid composition for use in preparing the β-MEND, which permits the particles to be efficiently internalized into MIN6, as evidenced by flow cytometry analyses. [Biomaterials] Abstract

Low pH Enhances Connexin32 Degradation in the Pancreatic Acinar Cell
Researchers evaluated the effects of low pH on gap junctions in the rat pancreatic acinar cell. Decreasing extracellular pH from 7.4 to 7.0 significantly inhibited gap junctional intracellular communication. [Am J Physiol Gastrointest Liver Physiol] Abstract

Targeting Nrf2 by Dihydro-CDDO-Trifluoroethyl Amide Enhances Autophagic Clearance and Viability of β-Cells in a Setting of Oxidative Stress
Scientists report that islet expression of Nrf2 is upregulated at an earlier stage of diabetes in both human and mice. Activation of Nrf2 suppresses oxidative stress and oxidative stress-induced β-cell apoptosis while enhancing autophagic clearance in isolated rat islets. [FEBS Lett] Abstract

Activation of eIF2α Signaling Cascade Is Associated with Testosterone-Induced Cell Apoptosis in INS-1 Cells
Researchers investigated the effect of testosterone on INS-1 cells to find whether excess androgen could produce endoplasmic reticulum stress thereby contributing to β-cell dysfunction. [Horm Metab Res] Abstract

Phospholipase C-Related Catalytically Inactive Protein (PRIP) Controls KIF5B-Mediated Insulin Secretion
Scientists investigated the role of PRIP in insulin granule exocytosis using Prip-knockdown mouse insulinoma cells. [Biology Open] Full Article


Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Genetic ablation of galectin-1 in a mouse model of pancreatic ductal adenocarcinoma dampened tumor progression by inhibiting proliferation, angiogenesis, desmoplasic reaction and by stimulating a tumor-associated immune response, yielding a 20% increase in relative lifesplan. Cellular analyses in vitro and in vivo suggested these effects were mediated through the tumor microenvironment. [Cancer Res] Abstract

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
Scientists found that the abundance of Yes-associated protein (YAP) mRNA, which encodes YAP, a protein regulated by the Hippo pathway during tissue development and homeostasis, was increased in human pancreatic ductal adenocarcinoma tissue compared with that in normal pancreatic epithelia. [Sci Signal] Abstract

BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen
Researchers showed that treatment with extra terminal domain (BET) inhibitors decreases growth of pancreatic ductal adenocarcinoma (PDAC) cells in collagen. Transfection with siRNA against bromodomain 4, which is increased in human PDAC tumors, also decreases growth of PDAC cells. [Mol Cancer Ther] Abstract

Targeting Insulin-Like Growth Factor 1 Receptor Inhibits Pancreatic Cancer Growth and Metastasis
Scientists investigated if an RNA interference approach targeted to IGF-IR could be effective and efficient against pancreatic cancer growth and metastasis. For that, they evaluated the effects of IGF-1R inhibition using small interfering RNA on tumor growth and metastasis in HPAC and PANC-1 pancreatic cancer cell lines. [PLoS One] Full Article

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Impaired Proteostasis: Role in the Pathogenesis of Diabetes Mellitus
There is growing evidence that the disruption of proteostasis may constitute a determining event in pathophysiology. The authors demonstrate how such a dysregulation may be involved in the pathogenesis of diabetes mellitus and in the onset of its long-term complications. [Diabetologia] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
ERYTECH Receives Authorization to Start Its Phase II Clinical Study in Pancreatic Cancer
ERYTECH Pharma announced that the ANSM, French healthcare agency, has granted the authorization to start a Phase II study in second line treatment of patients affected by pancreatic cancer. [ERYTECH Pharma]
Press Release

Lilly’s Basal Insulin Peglispro Shows Superiority in HbA1c Reduction Compared to Insulin Glargine in Three Phase III Trials in Patients with Type 2 Diabetes
Eli Lilly and Company announced positive top-line results of three completed Phase III clinical trials in patients with type 2 diabetes for basal insulin peglispro, which is being studied as a once-daily treatment for both type 1 and type 2 diabetes. [Eli Lilly and Company] Press Release

$4 Million from Eli and Edythe Broad Foundation will Support UCLA Research
Two new gifts from The Eli and Edythe Broad Foundation to UCLA totaling $4 million will fund research in stem cell science and digestive diseases and support the recruitment of key faculty at two renowned research centers. [UCLA] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Beatson International Cancer Conference
July 6-9, 2014
Glasgow, Scotland

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Staff Scientist and Postdoctoral Positions – Beta Cell Biology and Diabetes Research (Sanford Research / USD)

Research Assistant/Associate – Molecular Genetics and Biology of Pancreatic Cancer (University of Glasgow)

Postdoctoral Fellowship – Diabetes (Lund University Diabetes Center)

Postdoctoral Position – Pancreatic Cancer (CNIO – Spanish National Cancer Research Center)

Associate Academic Staff – Diagnosis, Prevention and Treatment of Diabetes (Vrije Universiteit Brussel)

PhD Studentship – Functional Role of MicroRNA in Vascular Complications of Diabetes (University of Edinburgh)

Postdoctoral Position – Diabetes (TAMHSC)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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