Volume 5.15 | Apr 22

Pancreatic Cell News 5.15 April 22, 2014
Pancreatic Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Cancer Stem Cells Linked to Drug Resistance
Researchers have discovered a molecule, or biomarker, called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of cancer cells. The findings may point to new therapeutic opportunities for reversing drug resistance in a range of cancers, including those in the lung, pancreas and breast. [Press release from the University of California, San Diego School of Medicine discussing online prepublication in Nature Cell Biology] Press Release | Abstract
Take the "if" out of "diff": Reduce variability when differentiating to endothelial cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
DIABETES & PANCREATITIS

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
Researchers demonstrated that ADCY5 is indispensable for coupling glucose, but not GLP-1, to insulin secretion in human islets. [Diabetes] Abstract

Pancreatic ß Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
Using a mouse model with ß cell specific deletion of Tsc2 and consequently mammalian target of rapamycin complex 1 (mTORC1) hyperactivation, scientists focused on the role that chronic mTORC1 hyperactivation might be having on ß cell failure. [Diabetes] Abstract

The Nucleotide Exchange Factor SIL1 Is Required for Glucose-Stimulated Insulin Secretion from Mouse Pancreatic Beta Cells In Vivo
Researchers showed that SIL1 is expressed in pancreatic beta cells and is required for islet insulin content, islet sizing, glucose tolerance and glucose-stimulated insulin secretion in vivo. [Diabetologia] Abstract

Indomethacin Treatment Prevents High-Fat Diet-Induced Obesity and Insulin Resistance, but Not Glucose Intolerance in C57BL/6J Mice
Researchers demonstrated that indomethacin did not inhibit glucose stimulated insulin-secretion per se, but activation of GPR40 in the presence of indomethacin inhibited glucose-dependent insulin secretion in MIN6 cells. [J Biol Chem] Abstract | Full Article

Co-Transplantation of Endothelial Progenitor Cells and Pancreatic Islets to Induce Long-Lasting Normoglycemia in Streptozotocin-Treated Diabetic Rats
Scientists co-transplanted endothelial progenitor cells and islets in the portal vein of chemically-induced diabetic rats to restore islet vascularization and to improve graft survival. [PLoS One] Full Article

PANCREATIC CANCER

Differentially Expressed miRNAs in Cancer Stem Like Cells: Markers for Tumor Cell Aggressiveness of Pancreatic Cancer
Researchers showed that isolated CD44+/CD133+/EpCAM+ cells from human pancreatic cancer cell lines, MiaPaCa-2 and L3.6pl cells display aggressive characteristics such as increased cell growth, clonogenicity, cell migration, and self-renewal capacity, which is consistent with over-expression of cancer stem like cell signatures/markers. [Stem Cells Dev] Abstract

Influence of Interferon-a on the Expression of the Cancer Stem Cell Markers in Pancreatic Carcinoma Cells
Researchers demonstrated for the first time that interferon-a up-regulates the expression of the cancer stem cells markers CD24, CD44 and CD133 in in vitro and in vivo models of pancreatic ductal adenocarcinoma. [Exp Cell Res] Abstract

7B7: A Novel Antibody Directed against the Ku70/Ku80 Heterodimer Blocks Invasion in Pancreatic and Lung Cancer Cells
A clonal population of the Mia PaCa-2, a pancreatic ductal adenocarcinoma cell line, which displays a highly invasive phenotype, was used to generate MAbs with the objective of identifying membrane targets directly involved in cancer invasion. [Tumor Biol] Abstract

GPC1 Regulated by miR-96-5p, Rather than miR-182-5p, in Inhibition of Pancreatic Carcinoma Cell Proliferation
Researchers investigated the proliferation, cycle and apotosis in cells transfected with mimics/inhibitors of the two miRNAs, and determine their effects on GPC1 by dual-luciferase assay. [Int J Mol Sci]
Abstract | Download Full Article

Designing of Promiscuous Inhibitors against Pancreatic Cancer Cell Lines
Scientists developed QSAR models for predicting promiscuous inhibitors using the pharmacological data. Their models have also successfully validated the drug-to-oncogene relationship and further they used these models to screen FDA approved drugs and tested them in vitro. [Sci Rep] Full Article

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REVIEWS
The Complex Landscape of Pancreatic Cancer Metabolism
The authors discuss the metabolic landscape of pancreatic ductal adenocarcinoma tumors, including the molecular underpinnings of the key regulatory nodes as well as describe how such pathways can be exploited for future diagnostic and therapeutic approaches. [Carcinogenesis] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
 
INDUSTRY NEWS
Scripps Florida Scientists Awarded $2 Million to Study Improvements in Anti-Diabetic Drug Design
Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.1 million from the National Institutes of Health to study the therapeutic potential of safer and more effective alternatives to the current crop of anti-diabetic drugs, which have been limited in their use due to side effects including bone loss and congestive heart failure. [The Scripps Research Institute] Press Release

Pancreatic Cancer ‘Dream Team’ Tackles Baffling, Deadly Disease
UC San Francisco has been selected to join a national “dream team” on pancreatic cancer, part of a project designed to accelerate treatment and discoveries for one of the most deadly forms of cancer. [University of California, San Francisco] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 10th Swiss Stem Cells Network (SSCN) Annual Meeting
June 4, 2014
Geneva, Switzerland

Visit our events page to see a complete list of events in the pancreatic cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Pancreatic Cancer (CNIO – Spanish National Cancer Research Center)

NEW Associate Academic Staff – Diagnosis, Prevention and Treatment of Diabetes (Vrije Universiteit Brussel)

Staff Scientist and Postdoctoral Fellow – Beta Cell Biology and Diabetes Research (Sanford Research/USD)

Postdoctoral Fellow – Pancreatic Cancer Research (University of Texas Health Science Center at San Antonio)

Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

PhD Studentship – Functional Role of MicroRNA in Vascular Complications of Diabetes (University of Edinburgh)

Postdoctoral Position – Diabetes (TAMHSC)

Senior Research Coordinator (Joslin Diabetes Center)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Diabetes (Université de Sherbrooke)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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