Volume 5.13 | Apr 8

Pancreatic Cell News 5.13 April 8, 2014
Pancreatic Cell News
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Senescence-Associated SIN3B Promotes Inflammation and Pancreatic Cancer Progression
Using a mouse model of pancreatic cancer, scientists demonstrated that SIN3B is required for activated KRAS-induced senescence in vivo. In murine and human pancreatic cells and tissues, levels of SIN3B correlated with KRAS-induced production of IL-1a. [J Clin Invest] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Evidence for Inhibitory Autocrine Effects of Proinsulin C-Peptide on Pancreatic Beta Cell Function and Insulin Secretion
Insulin releasing activity of human and rat C-peptides were studied in the clonal pancreatic cell line, BRIN-BD11, with findings substantiated using isolated islets and in vivo studies employing SWISS TO mice. [Diabetes Obes Metab] Abstract

Muscarinic Control of MIN6 Pancreatic ß Cells Is Enhanced by Impaired Amino Acid Signaling
Scientists found that expression of M3 receptors increased in T1R3-depleted MIN6 cells and calcium responses were altered. To determine if these changes were related to impaired amino acid signaling, they compared responses in cells exposed to reduced amino acid concentrations. [J Biol Chem] Abstract | Full Article

Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats
Adult rats were treated with a daily injection of dexamethasone (DEX) or saline as a control for five consecutive days. The characteristic inhibitory effect of glucose on glucagon secretion was impaired in the islets of the DEX rats, while no direct effects were found on a-cells in islets that were incubated with DEX in vitro. [PLoS One]
Full Article

Glutamate Formation via the Leucine-to-Glutamate Pathway of Rat Pancreas
Comparison of the Leu?Glu pathway in preparations of whole pancreatic segments, isolated acini, and islets of Langerhans localize it in the acini; relatively high activity is found in cultures of the AR42J cell line and very little in the INS-1 832/13 cell line. [Am J Physiol Gastrointest Liver Physiol] Abstract

Somatostatin Analog Inhibits the Growth of Insulinoma Cells by p27-Mediated G1 Cell Cycle Arrest
Researchers elucidated the therapeutic effect of octreotide (OCT) for insulinoma. Mouse insulinoma cell line MIN6 cells were cultured with OCT to clarify its antiproliferative effects, the expression of somatostatin receptor subtypes, cell cycle, p27 expression, and cdc2 kinase activity. [Pancreas] Abstract


Inflammation Induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D
Researchers outline a novel pathway whereby the transcription factors NFATc1 and STAT3 cooperate in pancreatic epithelial cells to promote KrasG12D-driven carcinogenesis. [Cancer Discov]
Abstract | Full Article

Upregulated SMAD3 Promotes Epithelial-Mesenchymal Transition and Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma
The nuclear accumulation of SMAD3 was immunohistochemically detected even in SMAD4-negative cases. SMAD3 knockdown resulted in upregulated E-cadherin, downregulated vimentin, and reduced cell motility in pancreatic cancer cells regardless of SMAD4 status. [Lab Invest] Abstract

PAR-3 Knockdown Enhances Adhesion Rate of PANC-1 Cells via Increased Expression of Integrinav and E-Cadherin
Since thrombin has been implicated in cancer progression, scientists studied the role(s) of thrombin-activated receptors in the adhesion process. They stably knocked down proteinase-activated receptors (PARs) -1, or -3 in human pancreatic adenocarcinoma PANC-1 cells. [PLoS One] Full Article

Triptolide Activates Unfolded Protein Response Leading to Chronic ER Stress in Pancreatic Cancer Cells
Researchers showed that triptolide induces unfolded protein response by activating the PERK-eIF2a axis and the Ire1a-Xbp-1 axis of unfolded protein response and leads to chronic ER stress in pancreatic cancer. [Am J Physiol Gastrointest Liver Physiol] Abstract

Take the "if" out of "diff": Reduce variability when differentiating to endothelial cells
Epidemiological-Molecular Evidence of Metabolic Reprogramming on Proliferation, Autophagy and Cell Signaling in Pancreas Cancer
The authors explore how nutrients and caloric intake may influence the KRAS-driven ductal carcinogenesis through mediators of metabolic stress, including autophagy in presence of TP53, advanced glycation end products and the receptors and ligands, as well as glutamine pathways, among others. Effective understanding the cancer metabolism mechanisms in pancreatic cancer may propose new ways of prevention and treatment. [Cancer Lett] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
Halozyme Announces Temporary Halt of Phase II Trial Enrollment and Dosing for PEGPH20
Halozyme Therapeutics, Inc. announced that as a result of a recommendation received from an independent Data Monitoring Committee, it is temporarily halting patient enrollment and dosing of PEGPH20 in an ongoing Phase II trial evaluating PEGPH20 in patients with pancreatic cancer. [Halozyme Therapeutics, Inc.]
Press Release

MannKind Updates Status of New Drug Application for AFREZZA®
MannKind Corporation announced that the U.S. Food and Drug Administration (FDA) has extended the Prescription Drug User Fee Act date for AFREZZA® by three months in order to provide time for a full review of information submitted by MannKind in response to the FDA’s requests. [MannKind Corporation] Press Release

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National Institutes of Health (United States)

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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW Gordon Research Conferences: Cell Death Mechanisms at the Interface of Health and Disease
June 8-13, 2014
West Dover, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

NEW PhD Studentship – Functional Role of MicroRNA in Vascular Complications of Diabetes (University of Edinburgh)

Research Fellow – Diabetes (Singapore Institute for Clinical Sciences)

Postdoctoral Position – Diabetes (TAMHSC)

Postdoctoral Fellow – Translational Pancreatic Cancer Research (Medical College of Wisconsin)

Senior Research Coordinator (Joslin Diabetes Center)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Diabetes (Université de Sherbrooke)

Postdoctoral Positions – Cancer and Diabetes (University of Pennsylvania)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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