Volume 5.11 | Mar 25

Pancreatic Cell News 5.11 March 25, 2014
Pancreatic Cell News
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Replacing Insulin through Stem Cell-Derived Pancreatic Cells under the Skin
Scientists have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells, and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs of the technology. [Press release from Sanford-Burnham Medical Research Institute discussing online prepublication in Stem Cell Research]
Press Release | Full Article
Derivation of Metabolically Active Hepatocytes from Pluripotent Stem Cells - View On-Demand Webinar Now.
PUBLICATIONS (Ranked by impact factor of the journal)

Calcium-Signaling Components in Rat Insulinoma ß-Cells (INS-1) and Pancreatic Islets Are Differentially Influenced by Melatonin
In a transfected INS-1 cell line overexpressing the human MT2 receptor, melatonin treatment induced even stronger depressive effects on calcium/calmodulin-dependent kinase 2d and IV transcripts during 3-isobutyl-1-methylxanthine treatment than in normal INS-1 cells, indicating a crucial influence of melatonin receptor density on transcript level regulation. [J Pineal Res] Abstract

SH2B1 in ß Cells Promotes Insulin Expression and Glucose Metabolism in Mice
Scientists identified SH2B1 as a new regulator of insulin expression. In rat INS-1 832/13 ß cells, SH2B1 knockdown decreased, whereas SH2B1 overexpression increased, both insulin expression and glucose-stimulated insulin secretion. [Mol Endocrinol] Abstract

Group VIA Phospholipase A2 Mitigates Palmitate-Induced Beta Cell Mitochondrial Injury and Apoptosis
Group VIA phospholipase A2 (iPLA2ß) affects ß-cell sensitivity to apoptosis, and researchers examined iPLA2ß effects on events that occur in ß-cells incubated with palmitate. [J Biol Chem] Abstract | Full Article

Elevation of NR4A3 Expression and Its Possible Role in Modulating Insulin Expression in the Pancreatic Beta Cell
Dynamic changes in NR4A3 were examined in a pancreatic beta-cell line, MIN6, treated with thapsigargin, palmitate, tunicamycin, and dithiothreitol, chemicals that produce cell stress and even apoptosis. [PLoS One] Full Article


CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Overexpression of CLPTM1L enhanced growth of pancreatic cancer cells in vitro and in vivo, suggesting a role in tumor growth. [Cancer Res] Abstract

Activation of Glucagon-Like Peptide-1 Receptor Inhibits Tumorigenicity and Metastasis of Human Pancreatic Cancer Cells via PI3K/Akt Pathway
Glucagon-like peptide-1 receptor activation with liraglutide inhibited tumorigenicity and metastasis of human pancreatic cancer cells in vitro and in vivo. [Diabetes Obes Metab] Abstract

Development of High-Content Gemcitabine PEGylated Liposomes and Their Cytotoxicity on Drug-Resistant Pancreatic Tumor Cells
Researchers developed high-content gemcitabine PEGylated liposomes to reverse gemcitabine resistance in pancreatic tumor cells. The mechanism of drug loading into liposomes was also investigated. [Pharm Res] Abstract

The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer
Notch pathway components were found to be upregulated in pancreatic cancer stem cells (CSCs). Inhibition of the Notch pathway using either a gamma secretase inhibitor or Hes1 shRNA in pancreatic cancer cells reduced the percentage of CSCs and tumorsphere formation. [PLoS One] Full Article

A Triple Combination of Atorvastatin, Celecoxib and Tipifarnib Strongly Inhibits Pancreatic Cancer Cells and Xenograft Pancreatic Tumors
Researchers found that treatment of human pancreatic tumor cells with a combination of atorvastatin, celecoxib and tipifarnib had a stronger inhibitory effect on growth and a stronger stimulatory effect on apoptosis than each drug alone or for any combination of two drugs. [Int J Oncol] Abstract

Webinar: Affordable, Defined hPSC Culture? Watch the video now.
Concise Review: Pluripotent Stem Cell-Based Regenerative Applications for Failing ß-Cell Function
In light of emerging clinical experiences with human embryonic stem cells and approval of the first in-human trial with induced pluripotent stem cells, the authors highlight advances in ß-cell regeneration strategies with a focus on pluripotent stem cell platforms in the context of translational applications. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Cell Line Development Asia 2014
$4.25 Million Grant Awarded to Rutgers Cancer Institute of New Jersey and University of Wisconsin Carbone Cancer Center to Develop Innovative Clinical Trials
Precision medicine, or the movement to ‘personalize’ cancer treatments, has grown significantly over the past few years, with researchers from large universities and cancer centers from across the nation making advances in identifying targeted therapies and understanding what drives them. Aiming to further build on that momentum with the development of innovative early-phase clinical trials examining genomic and therapeutic biomarkers is Robert S. DiPaola. [Rutgers Cancer Institute of New Jersey] Press Release

Ohio State Partners with MedVax Technologies, Inc. to Bring a Cancer Peptide Vaccine to Patients
The Ohio State University, through the Ohio State Innovation Foundation, has signed an exclusive world-wide licensing agreement with MedVax Technologies, Inc., for the licensing of groundbreaking cancer peptide vaccine technologies. [The Ohio State University] Press Release

From our sponsor: Learn about assays for cord blood. Download the free technical bulletin.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Controlling Cancer Summit 2014
May 12-14, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Position – Diabetes (TAMHSC)

Postdoctoral Fellow – Translational Pancreatic Cancer Research (Medical College of Wisconsin)

Senior Research Coordinator (Joslin Diabetes Center)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Postdoc Researcher – Diabetes (Indiana University School of Medicine)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Studentship – Molecular Drug Resistance (Institute of Cancer Research)

Postdoctoral Position – Diabetes (Université de Sherbrooke)

Postdoctoral Position – Diabetes Research (Tel Aviv University)

Postdoctoral Position – Diabetes (Washington University School of Medicine)

Postdoctoral Research Fellow/Associate – Diabetes, Metabolism and Molecular Endocrinology (University of Illinois)

Postdoctoral Positions – Cancer and Diabetes (University of Pennsylvania)

Postdoctoral Fellow – Stem Cell Biology (McEwen Centre for Regenerative Medicine/University Health Network)

Postdoctoral Associate Specialist – Human Pancreatic Stem Cell Research (The Nestlé Institute of Health Sciences)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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