Volume 5.10 | Mar 18

Pancreatic Cell News 5.10 March 18, 2014
Pancreatic Cell News
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MST1 Is a Key Regulator of Beta Cell Apoptosis and Dysfunction in Diabetes
Researchers identified mammalian sterile 20-like kinase-1 (MST1) as a critical regulator of apoptotic beta cell death and function. Under diabetogenic conditions, MST1 was strongly activated in beta cells in human and mouse islets and specifically induced the mitochondrial-dependent pathway of apoptosis through upregulation of the BCL-2 homology-3-only protein BIM. [Nat Med] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

RFamide Peptides 43RFa and 26RFa Both Promote Survival of Pancreatic ß-Cells and Human Pancreatic Islets but Exert Opposite Effects on Insulin Secretion
Researchers investigated the effects of 43RFa and 26RFa on survival and apoptosis of pancreatic ß-cells and human pancreatic islets. [Diabetes] Abstract

The Proapoptotic BH3-Only Proteins Bim and Puma Are Downstream of Endoplasmic Reticulum and Mitochondrial Oxidative Stress in Pancreatic Islets in Response to Glucotoxicity
Researchers demonstrated that high concentrations of glucose induce endoplasmic reticulum and oxidative stress, which causes cell death mediated by Bim and Puma. They observed significantly higher Bim and Puma mRNA in islets of human donors with type 2 diabetes. [Cell Death Dis] Full Article

Inhibition of Pancreatic Beta-Cell CaMKII Reduces Glucose-Stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance
Investigators report that mice with conditional inhibition of CaMKII in ß-cells show significantly impaired glucose tolerance due to decreased glucose stimulated insulin secretion. [J Biol Chem] Abstract | Full Article

Targeting SUR1/Abcc8-Type Neuroendocrine KATP Channels in Pancreatic Islet Cells
Abcc8/Sur1 flox mice were generated and tested by crossing with glucagon-cre mice to target a-cell KATP channels selectively. [PLoS One] Full Article


CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Using a synthetic lethal screen in human pancreatic ductal adenocarcinoma cells, scientists identified 93 genes including 55 genes linked to DNA damage responses that demonstrated gemcitabine sensitization when silenced, including CHD7 which functions in chromatin remodeling. [Cancer Res] Abstract

Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells
Hedgehog acyltransferase knockdown inhibited Hedgehog autocrine and juxtacrine signaling, and inhibited pancreatic ductal adenocarcinoma cell growth and invasiveness in vitro. [PLoS One] Abstract | Press Release

SMAD4 Loss Triggers the Phenotypic Changes of Pancreatic Ductal Adenocarcinoma Cells
Researchers report that re-expression of SMAD4 in SMAD4-null pancreatic ductal adenocarcinoma cells does not affect tumor cell growth in vitro or in vivo, but significantly enhances cells migration in vitro. [BMC Cancer] Abstract | Full Article

S100P Antibody-Mediated Therapy as a New Promising Strategy for the Treatment of Pancreatic Cancer
Scientists showed that extracellular S100P stimulates pancreatic carcinoma BxPC3 cell line by promoting cell proliferation. They also demonstrated that S100P induces, in this cell line, the phosphorylation of I?Ba and the secretion of matrix metalloproteinase 9. [Oncogenesis] Full Article

Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
Lipotoxic Endoplasmic Reticulum Stress, ß Cell Failure, and Type 2 Diabetes Mellitus
The authors update recent progress on how fatty acids initiate endoplasmic reticulum stress, particularly via disruption of protein trafficking, and how this leads to apoptosis. They also highlight differences in how ß cells are impacted by the classic unfolded protein response (UPR), versus the more selective UPR that arises as part of a broader response to lipotoxicity. [Trends Endocrinol Metab] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
Theracos Reports Positive Outcomes from a 96-week Phase II Study of THR1442, a Highly Specific SGLT2 Inhibitor, for the Treatment of Type 2 Diabetes
Theracos, Inc. announced the results of a multinational 96-week Phase II study evaluating the efficacy and safety of the SGLT-2 inhibitor THR1442. The double-blinded, placebo-controlled study enrolled a total of 288 subjects with Type 2 diabetes from sites in the US, Mexico and Colombia and evaluated the efficacy of THR1442 compared to placebo as a monotherapy for the treatment of diabetes. [Theracos, Inc.] Press Release

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Specialised Therapeutics Australia Receives Therapeutic Goods Administration Approval for Abraxane(R) in Combination with Gemcitabine for First-Line Treatment of Metastatic Pancreatic Cancer
Australian biopharmaceutical company Specialised Therapeutics Australia announced that ABRAXANE® (nanoparticle albumin-bound paclitaxel) in combination with gemcitabine in now approved by the Therapeutic Goods Administration for the first-line treatment of metastatic pancreatic cancer. [PR Newswire Association LLC] Press Release

OncoSil Medical Commences Pivotal Trial for OncoSilTM in Pancreatic Cancer
OncoSil Medical Limited announced that it has commenced its Pivotal Clinical Trial for its lead product candidate, the OncoSil™ localized radiation therapy for the treatment of pancreatic cancer. [OncoSil Medical Limited] Press Release
Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer and Mark Kirk. [Alliance for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW World Stem Cells & Regenerative Medicine Congress 2014
May 20-22, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the pancreatic cell community.
NEW Postdoctoral Fellow – Translational Pancreatic Cancer Research (Medical College of Wisconsin)

NEW Senior Research Coordinator (Joslin Diabetes Center)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Postdoc Researcher – Diabetes (Indiana University School of Medicine)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Studentship – Molecular Drug Resistance (Institute of Cancer Research)

Postdoctoral Position – Diabetes (Université de Sherbrooke)

Postdoctoral Position – Diabetes Research (Tel Aviv University)

Postdoctoral Position – Diabetes (Washington University School of Medicine)

Postdoctoral Research Fellow/Associate – Diabetes, Metabolism and Molecular Endocrinology (University of Illinois)

Postdoctoral Positions – Cancer and Diabetes (University of Pennsylvania)

Postdoctoral Fellow – Stem Cell Biology (McEwen Centre for Regenerative Medicine/University Health Network)

Postdoctoral Associate Specialist – Human Pancreatic Stem Cell Research (The Nestlé Institute of Health Sciences)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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