Volume 5.06 | Feb 18

Pancreatic Cell News 5.06 February 18, 2014
Pancreatic Cell News
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Inhibition of p53 Preserves Parkin-Mediated Mitophagy and Pancreatic ß-Cell Function in Diabetes
Scientists showed that p53 deficiency protects against the development of diabetes in streptozotocin-induced type 1 and db/db mouse models of type 2 diabetes. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

The MafA Transcription Factor Becomes Essential to Islet ß-Cells Soon after Birth
Researchers found that islet cell organization, ß-cell mass and ß-cell function were influenced by three weeks of age in Mafa?panc mice, and compromised earlier in Mafa?panc;Mafb+/- mice. [Diabetes] Abstract

ß Cell Proliferation after a Partial Pancreatectomy Is Independent of IRS-2 in Mice
Researchers investigated the role of insulin receptor substrate 2 (IRS-2) in the proliferation of ß cells following a 60% partial pancreatectomy. [Endocrinology] Abstract

D-Chiro-Inositol Glycan Stimulates Insulin Secretion in Pancreatic ß Cells
Researchers found that INS-2 stimulates insulin secretion in MIN6 ß cells and potentiates glucose stimulated insulin secretion in isolated mouse islets. [Mol Cell Endocrinol] Abstract

Mechanisms Involved in the Inhibitory Effect of Chronic Alcohol Exposure on Pancreatic Acinar Thiamin Uptake
Scientists aimed to confirm the involvement of a transcriptional mechanism in mediating the chronic alcohol effect in in vivo settings, and to delineate the molecular mechanisms involved. [Am J Physiol Gastrointest Liver Physiol] Abstract

Protective Role of Sodium Butyrate, a HDAC Inhibitor on Beta-Cell Proliferation, Function and Glucose Homeostasis through Modulation of p38/ERK MAPK and Apoptotic Pathways: Study in Juvenile Diabetic Rat
Scientists investigated the protective role of sodium butyrate treatment on the beta-cell proliferation, function and glucose homeostasis as well as apoptosis in juvenile diabetic rat. [Chem Biol Interact] Abstract


Combined Targeting of STAT3/NF-?B/COX-2/EP4 for Effective Management of Pancreatic Cancer
Scientists determined whether targeting STAT3/NF-?B crosstalk with a natural product Nexrutine can inhibit inflammatory signaling in pancreatic cancer. Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis. [Clin Cancer Res] Abstract

The Novel EpCAM-Targeting Monoclonal Antibody 3-17I Linked to Saporin Is Highly Cytotoxic after Photochemical Internalization in Breast, Pancreas and Colon Cancer Cell Lines
Scientists present the characterization and therapeutic potential of a novel, fully human epithelial cell adhesion molecule (EpCAM)-targeting mAb, 3-17I. Cell viability, proliferation and colony-forming capacity was strongly reduced in a light-dependent manner after photochemical internalization of 3-17I. [MAbs] Abstract

Fibrogenesis in Pancreatic Cancer Is a Dynamic Process Regulated by Macrophage-Stellate Cell Interaction
Researchers describe the dynamic remodeling that occurs from pancreatic precursors (pancreatic intraepithelial neoplasias) to pancreatic ductal adenocarcinoma, highlighting similarities and differences between benign and malignant disease. [Lab Invest] Abstract

MiR-200a Inhibits Epithelial-Mesenchymal Transition of Pancreatic Cancer Stem Cell
Pancreatic cancer cells with epithelial-to-mesenchymal transition phenotype displayed stem-like cell features characterized by the expression of cell surface markers CD24, CD44 and epithelial-specific antigen, which was associated with decreased expression of miR-200a. [BMC Cancer] Full Article

Perifosine Inhibits S6K1-Gli1 Signaling and Enhances Gemcitabine-Induced Anti-Pancreatic Cancer Efficiency
Researchers investigated the potential effect of perifosine, a novel Akt inhibitor on gemcitabine-induced anti-pancreatic cancer effect both in vivo and in vitro. [Cancer Chemother Pharmacol] Abstract

Anti-Inflammatory Macrophages Activate Invasion in Pancreatic Adenocarcinoma by Increasing the MMP9 and ADAM8 Expression
Researchers examined the role of the inflammatory cells in the invasion of pancreatic cancer cells, focusing on the involvement of a disintegrin and metalloproteinase 8 (ADAM8) and matrix metalloproteinase 9 (MMP9) proteins. [Med Oncol] Abstract

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Targeting the Pancreatic ß-Cell to Treat Diabetes
The authors provide an overview of the latest developments in this field, with an emphasis on the most promising strategies identified to date for treating diabetes by targeting the ß-cell. [Nat Rev Drug Discov] Abstract

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DiaVacs Announces a Strategic Collaboration with Profil Institute to Conduct Phase IB/IIA Randomized Clinical Trial of New Cell-Based Therapy for Type 1 Diabetes
DiaVacs, Inc. and Profil® Institute for Clinical Research, Inc. announced a strategic collaboration to conduct DiaVacs’ Phase Ib/IIa clinical trial. This clinical trial will study the safety and preliminary efficacy of DiaVacs’ novel dendritic cell therapy for treatment of type 1 diabetes in patients who are newly diagnosed. [Profil® Institute for Clinical Research, Inc.] Press Release

Aduro BioTech Announces Initiation of Phase IIb ECLIPSE Trial to Evaluate Treatment of Patients with Pancreatic Cancer with the Company’s Innovative Immunotherapies
Aduro BioTech, Inc. announced the initiation of a Phase IIb clinical trial of the company’s immunotherapies GVAX Pancreas and CRS-207. [BusinessWire] Press Release

MicroBiome Therapeutics™ Reports Positive Top-Line Results from Clinical Trial of Microbiome Modulator NM504 in Type 2 Diabetes
MicroBiome Therapeutics™ LLC announced positive top-line results from the company’s clinical trial of lead microbiome modulator NM504 in development for type 2 diabetes and prediabetes. [MicroBiome Therapeutics™ LLC] Press Release

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NEW Tumor Microenvironment and Signaling
May 7-10, 2014
Heidelberg, Germany

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NEW Postdoctoral Position – Diabetes (Washington University School of Medicine)

NEW Postdoctoral Research Fellow/Associate – Diabetes, Metabolism and Molecular Endocrinology (University of Illinois)

NEW Postdoctoral Positions – Cancer and Diabetes (University of Pennsylvania)

NEW Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

NEW Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

NEW Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Stem Cell Biology (McEwen Centre for Regenerative Medicine/University Health Network)

Postdoctoral Associate Specialist – Human Pancreatic Stem Cell Research (The Nestlé Institute of Health Sciences)

Postdoctoral Research Scientist – Imaging GTPase Activation in Cancer (Cancer Research UK Beatson Institute in Glasgow)

Postdoctoral Research Scientist – RAC and RAL Signaling Downstream of KRAS Mutation in Pancreatic and Colon Cancer (Cancer Research UK Beatson Institute in Glasgow)

Postdoctoral Fellowship Position – Mechanisms of Action in Obesity and Diabetes Pathogenesis (NIH/NIDDK)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

PhD Student Position – Diabetes and Bone Regeneration (KU Leuven)

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