|PUBLICATIONS (Ranked by impact factor of the journal)|
DIABETES & PANCREATITIS|
The MafA Transcription Factor Becomes Essential to Islet ß-Cells Soon after Birth
Researchers found that islet cell organization, ß-cell mass and ß-cell function were influenced by three weeks of age in Mafa?panc mice, and compromised earlier in Mafa?panc;Mafb+/- mice. [Diabetes]
ß Cell Proliferation after a Partial Pancreatectomy Is Independent of IRS-2 in Mice
Researchers investigated the role of insulin receptor substrate 2 (IRS-2) in the proliferation of ß cells following a 60% partial pancreatectomy. [Endocrinology]
D-Chiro-Inositol Glycan Stimulates Insulin Secretion in Pancreatic ß Cells
Researchers found that INS-2 stimulates insulin secretion in MIN6 ß cells and potentiates glucose stimulated insulin secretion in isolated mouse islets. [Mol Cell Endocrinol]
Mechanisms Involved in the Inhibitory Effect of Chronic Alcohol Exposure on Pancreatic Acinar Thiamin Uptake
Scientists aimed to confirm the involvement of a transcriptional mechanism in mediating the chronic alcohol effect in in vivo settings, and to delineate the molecular mechanisms involved. [Am J Physiol Gastrointest Liver Physiol]
Protective Role of Sodium Butyrate, a HDAC Inhibitor on Beta-Cell Proliferation, Function and Glucose Homeostasis through Modulation of p38/ERK MAPK and Apoptotic Pathways: Study in Juvenile Diabetic Rat
Scientists investigated the protective role of sodium butyrate treatment on the beta-cell proliferation, function and glucose homeostasis as well as apoptosis in juvenile diabetic rat. [Chem Biol Interact]
Combined Targeting of STAT3/NF-?B/COX-2/EP4 for Effective Management of Pancreatic Cancer
Scientists determined whether targeting STAT3/NF-?B crosstalk with a natural product Nexrutine can inhibit inflammatory signaling in pancreatic cancer. Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis. [Clin Cancer Res]
The Novel EpCAM-Targeting Monoclonal Antibody 3-17I Linked to Saporin Is Highly Cytotoxic after Photochemical Internalization in Breast, Pancreas and Colon Cancer Cell Lines
Scientists present the characterization and therapeutic potential of a novel, fully human epithelial cell adhesion molecule (EpCAM)-targeting mAb, 3-17I. Cell viability, proliferation and colony-forming capacity was strongly reduced in a light-dependent manner after photochemical internalization of 3-17I. [MAbs]
Fibrogenesis in Pancreatic Cancer Is a Dynamic Process Regulated by Macrophage-Stellate Cell Interaction
Researchers describe the dynamic remodeling that occurs from pancreatic precursors (pancreatic intraepithelial neoplasias) to pancreatic ductal adenocarcinoma, highlighting similarities and differences between benign and malignant disease. [Lab Invest]
MiR-200a Inhibits Epithelial-Mesenchymal Transition of Pancreatic Cancer Stem Cell
Pancreatic cancer cells with epithelial-to-mesenchymal transition phenotype displayed stem-like cell features characterized by the expression of cell surface markers CD24, CD44 and epithelial-specific antigen, which was associated with decreased expression of miR-200a. [BMC Cancer]
Perifosine Inhibits S6K1-Gli1 Signaling and Enhances Gemcitabine-Induced Anti-Pancreatic Cancer Efficiency
Researchers investigated the potential effect of perifosine, a novel Akt inhibitor on gemcitabine-induced anti-pancreatic cancer effect both in vivo and in vitro. [Cancer Chemother Pharmacol]
Anti-Inflammatory Macrophages Activate Invasion in Pancreatic Adenocarcinoma by Increasing the MMP9 and ADAM8 Expression
Researchers examined the role of the inflammatory cells in the invasion of pancreatic cancer cells, focusing on the involvement of a disintegrin and metalloproteinase 8 (ADAM8) and matrix metalloproteinase 9 (MMP9) proteins. [Med Oncol]
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Targeting the Pancreatic ß-Cell to Treat Diabetes|
The authors provide an overview of the latest developments in this field, with an emphasis on the most promising strategies identified to date for treating diabetes by targeting the ß-cell. [Nat Rev Drug Discov]
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