Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Activation of the PI3K/AKT Signaling Pathway by ARNTL2 Enhances Cellular Glycolysis and Sensitizes Pancreatic Adenocarcinoma to Erlotinib
[Molecular Cancer] Investigators examined the levels of various cancer hallmarks and identified glycolysis as the primary risk factor for overall survival in pancreatic cancer.
Clonal Dominance Defines Metastatic Dissemination in Pancreatic Cancer
[Science Advances] Using patient-derived pancreatic cancer cells, the authors created orthotopically implanted clonal replica tumors to trace clonal dynamics of unperturbed tumor expansion and dissemination.
A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer
[Cancer Research] Researchers showed that hypoxia drives long-lasting epithelial-mesenchymal transition (EMT) in PDAC primarily through a positive-feedback histone methylation-MAPK signaling axis.
Inhibition of Glycogen Synthase Kinase-3 Enhances NRF2 Protein Stability, Nuclear Localisation, and Target Gene Transcription in Pancreatic Beta Cells
[Redox Biology] Inhibition of Glycogen Synthase Kinase-3 Enhances NRF2 Protein Stability, Nuclear Localisation, and Target Gene Transcription in Pancreatic Beta Cells
Delivery of a BET Protein Degrader via a CEACAM6-Targeted Antibody–Drug Conjugate Inhibits Tumor Growth in Pancreatic Cancer Models
[Nature Communications] To improve PDAC therapy, researchers established screening systems based on organoid and co-culture technologies and found a payload of antibody–drug conjugate, a bromodomain and extra-terminal (BET) protein degrader named EBET.
PRMT1 Promotes Pancreatic Cancer Development and Resistance to Chemotherapy
[Cell Reports Medicine] Investigators showed that PRMT1 was highly expressed in murine and human pancreatic cancer and was essential for cancer cell proliferation and tumorigenesis.
Role of β-Cell Autophagy in β-Cell Physiology and the Development of Diabetes
[Journal of Diabetes Investigation] The results from studies on the role of autophagy in β-cells and their implication in the development of diabetes as well as the role and mechanisms of non-selective (macro)autophagy, selective autophagy, and other minor forms of autophagy that might occur in β-cells are discussed.
FDA Clears First Over-the-Counter Continuous Glucose Monitor
[FDA] The US FDA cleared for marketing the first over-the-counter continuous glucose monitor (CGM). The Dexcom Stelo Glucose Biosensor System is an integrated CGM intended for anyone 18 years and older who does not use insulin.
Exosomal lncRNA XIST Promotes Perineural Invasion of Pancreatic Cancer Cells via miR-211-5p/GDNF
[Oncogene] Scientists revealed that exosomal lncXIST derived from pancreatic cancer cells was delivered to neural cells and promoted their release of glial-cell-line-derived neurotrophic factor.
tiRNA-Val-CAC-2 Interacts with FUBP1 to Promote Pancreatic Cancer Metastasis by Activating c-MYC Transcription
[Oncogene] Investigators screened and identified tiRNA-Val-CAC-2 as highly expressed in pancreatic cancer metastasis samples by transfer RNA-derived small RNA sequencing.
Effect of Ergocalciferol on β-Cell Function in New-Onset Type 1 Diabetes
[Jama Network Open] Researchers conducted a post hoc secondary analysis of a single-center, double-blind, placebo-controlled, parallel-group randomized clinical trial of ergocalciferol vs placebo in youths with newly diagnosed T1D.
Cytidine Deaminases APOBEC3C and APOBEC3D Promote DNA Replication Stress Resistance in Pancreatic Cancer Cells
[Nature Cancer] To define the cancer cell response to gemcitabine, researchers performed genome-scale CRISPR–Cas9 chemical–genetic screens in PDAC cells and found selective loss of cell fitness upon disruption of the cytidine deaminases APOBEC3C and APOBEC3D.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.