Volume 4.44 | Nov 12

Pancreatic Cell News 4.44 November 12, 2013
Pancreatic Cell News
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MicroRNA-10b Enhances Pancreatic Cancer Cell Invasion by Suppressing TIP30 Expression and Promoting EGF and TGF-β Actions
Investigators determined that plasma microRNA-10b (miR-10b) levels are significantly increased in pancreatic ductal adenocarcinoma patients by comparison with normal controls. By gene profiling, they identified potential targets downregulated by miR-10b, including Tat-interacting protein 30 (TIP30). [Oncogene]
Full Article
| Press Release
New TeSR™-E8™ is Here  For Feeder-Free Culture of Human ES Cells and iPS Cells
PUBLICATIONS ( Ranked by impact factor of the journal)

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells
Combining conditional loss-of-function and lineage tracing approaches, researchers showed that the selective inhibition of the Arx gene in α-cells is sufficient to promote the conversion of adult α-cells into β-like cells at any age. [PLoS Genet] Full Article

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats through mTOR and FOXM1
The authors previously reported that a 72-hour co-infusion of glucose and Intralipid induces insulin resistance and a marked increase in β-cell proliferation in 6-month-old but not in 2-month-old Wistar rats. Here, they aimed to identify the mechanisms underlying nutrient-induced β-cell proliferation in this model. [Diabetes] Abstract

Caffeic Acid, Naringenin and Quercetin Enhance Glucose Stimulated Insulin Secretion and Glucose Sensitivity in INS-1E Cells
Caffeic acid, naringenin and quercetin are naturally occurring phenolic compounds present in many plants as secondary metabolites. Researchers investigated their effect on glucose stimulated insulin secretion in INS-1E cells and to explore their effect on expression of genes involved in beta cell survival and function under normoglycemic and glucotoxic conditions.[Diabetes Obes Metab] Abstract

Amniotic Fluid Stem Cells Prevent β-Cell Injury
The authors used a chemically induced mouse model of type 1 diabetes to determine whether amniotic fluid stem cells could play a role in modulating β-cell injury and restoring β-cell function. [Cytotherapy] Abstract

Glucose Promotes Its Own Metabolism by Acting on the Cell-Surface Glucose-Sensing Receptor T1R3
To determine the role of homodimer of taste type 1 receptor 3 (T1R3) in glucose-induced insulin secretion, scientists addressed whether or not this receptor modulates glucose metabolism in MIN6 cells. They measured changes in intracellular ATP in MIN6 cells expressing luciferase. [Endocr J]
| Full Article


O-GlcNAcylation of FoxO1 in Pancreatic β Cells Promotes Akt Inhibition through an IGFBP1-Mediated Autocrine Mechanism
FoxO1 was O-GlcNAcylated in INS-1 832/13 β cells and isolated rat pancreatic islets. O-GlcNAcylation of FoxO1 resulted in a two-fold increase in its transcriptional activity toward a FoxO1 reporter gene and a 3-fold increase in the expression of the insulin-like growth factor-binding protein 1 (Igfbp1) gene at the mRNA level, resulting in IGFBP1 protein oversecretion by the cells. [FASEB J] Abstract

Pancreatic Stellate Cells Promote Hapto-Migration of Cancer Cells through Collagen I-Mediated Signaling Pathway
Investigators used a modified Boyden chamber assay as an in vitro model to investigate the role of pancreatic stellate cells in migration of Panc1 and UlaPaCa cells and to identify the underlying mechanisms. [Brit J Cancer] Abstract

Targeting Elongation Factor-2 Kinase (eEF-2K) Induces Apoptosis in Human Pancreatic Cancer Cells
Scientists showed that eEF-2K is overexpressed in pancreatic cancer (PaCa) cells and its down-regulation induces apoptotic cell death. Rottlerin, a polyphenolic compound initially identified as a PKC-δ inhibitor, induces apoptosis and autophagy in a variety of cancer cells including PaCa cells. [Apoptosis] Abstract

Emetine Enhances the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Pancreatic Cancer Cells by Downregulation of Myeloid Cell Leukemia Sequence-1 Protein
To investigate the mechanism underlying pancreatic cancer cell resistance to tumor necrosis factor-related apoptosis-inducing ligand, researchers performed a small scale high-throughput compound screening in AsPC-1 pancreatic cancer cells using a bioactive small molecule library. [Oncol Rep] Abstract

Differentiation Doesn't Have to be Difficult  Get Easy, Standardized hPSC Differentiation
Cooperation between Brain and Islet in Glucose Homeostasis and Diabetes
The authors present evidence of a brain-centered glucoregulatory system (BCGS) that can lower blood glucose levels via both insulin-dependent and -independent mechanisms, and propose a model in which complex and highly coordinated interactions between the BCGS and pancreatic islets promote normal glucose homeostasis. [Nature] Abstract | Press Release

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MU Study Finds More Accurate Method to Diagnose Pancreatic Cancer
Researchers from the University of Missouri (MU) have found a more accurate laboratory method for diagnosing pancreatic cancer. To develop the new diagnostic method, researchers performed a retrospective study of the records from 57 patients at University of Missouri Health Care who were tested for pancreatic cancer. [Press release from University of Missouri discussing research presented at the American Society for Clinical Pathology’s 2013 Annual Meeting, Chicago] Press Release

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Nuvilex Completes Acquisition of Exclusive Worldwide Rights to Live-Cell Encapsulation Technology for Diabetes
Nuvilex, Inc. announced that it has acquired the exclusive worldwide rights to use the cellulose-based live-cell encapsulation technology for the development of treatments for diabetes from SG Austria Pte. Ltd. [Nuvilex, Inc.] Press Release

Cornerstone Pharmaceuticals Announces Initiation of Phase II Clinical Trial of CPI-613 in Patients with Locally Advanced or Metastatic Pancreatic Cancer
Cornerstone Pharmaceuticals, Inc. announced the initiation of a pilot Phase II clinical trial of CPI-613 for the treatment of patients with locally advanced or metastatic pancreatic cancer. CPI-613 is the Company’s lead Altered Energy Metabolism Directed drug candidate, which is designed to disrupt the altered energy-production pathways in cancer cells. [Cornerstone Pharmaceuticals, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Annual Meeting of the American Association for Cancer Research (AACR) Annual Meeting 2014
April 5-9, 2014
San Diego, United States

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NEW Postdoctoral Fellow Positions – Beta Cell Maintenance in Health and Diabetes (Tel Aviv University)

Postdoctoral Fellow – Novel Genes in Pancreatic Beta Cell Function (University of California – San Francisco)

Postdoctoral Associate Position – Molecular Mechanisms of Insulin Resistance and Beta-Cell Failure in Type 2 Diabetes (Nencki Institute of Experimental Biology)

Research Fellow – Cellular Immunity in Type 1 Diabetes (King’s College London)

Postdoctoral Position – Cell Metabolism, Diabetes and Fatty Liver Disease (Boston University)

Postdoctoral Associate – Human and Mouse Stem Cell Biology, Pancreatic and Liver Specification and In Vitro Disease Modeling (Baylor College of Medicine)

Postdoctoral Fellow – Molecular Mechanisms of Cancer Progression (University of South Alabama)

Faculty Position – Department of Cellular & Structural Biology (The University of Texas Health Science Center at San Antonio)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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