Volume 3.23 | Jun 12

DIABETES

Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
Researchers concluded that adipose-derived mesenchymal stem cell therapy efficiently ameliorates autoimmune diabetes pathogenesis in diabetic NOD mice by attenuating the Th1 immune response concomitant with the expansion/proliferation of regulatory T cells, thereby contributing to the maintenance of functional β-cells. [Diabetes] Abstract

A Notch-Dependent Molecular Circuitry Initiates Pancreatic Endocrine and Ductal Cell Differentiation
Findings establish a novel role for Notch in initiating both ductal and endocrine development and reveal that Notch does not function in an on-off mode, but that a gradient of Notch activity produces distinct cellular states during pancreas development. [Development] Abstract

Human Mesenchymal Stem Cells Protect Human Islets from Pro-Inflammatory Cytokines
Islet β cell apoptosis was observed in the presence of cytokines; however, culture of bone marrow derived mesenchymal stem cells with islets prevented β cell apoptosis after cytokine treatment. [PLoS One]
Full Article

Modulating Zymogen Granule Formation in Pancreatic AR42J Cells
Researchers demonstrated that granule formation in pancreatic AR42J cells, an acinar model system, can be modulated by altering the growth conditions in cell culture. [Exp Cell Res] Abstract

In Vivo Studies on Non-Viral Transdifferentiation of Liver Cells towards Pancreatic Beta Cells
The authors concluded that hydrodynamic gene delivery of multiple transcription factors to rat liver can initiate transdifferentiation to pancreatic β cells, but the process is reversible, and probably requires more sustained transcription factor expression. [J Endocrinol] Abstract

PANCREATIC CANCER

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
The suppression of GM-CSF production inhibits the in vivo growth of Kras^G12D-pancreatic ductal epithelial cells, and, consistent with the role of GM-CSF in Gr1⁺CD11b⁺ mobilization, this effect is mediated by CD8⁺ T cells. [Cancer Cell] Abstract | Press Release

Claudin-4-Targeted Optical Imaging Detects Pancreatic Cancer and Its Precursor Lesions
Researchers investigated the potential of targeting claudin-4 with a naturally occurring ligand to visualize pancreatic cancer and its precursor lesions in vitro and in vivo by near-infrared imaging approaches. [Gut] Abstract

Overexpression of CIAPIN1 Inhibited Pancreatic Cancer Cell Proliferation and Was Associated with Good Prognosis in Pancreatic Cancer
Investigators evaluated the prognostic value of cytokine-induced antiapoptotic molecule (CIAPIN1) in pancreatic cancer and probed its function in pancreatic carcinogenesis. [Cancer Gene Ther] Abstract

Experimental In Vivo and In Vitro Treatment with a New Histone Deacetylase Inhibitor Belinostat Inhibits the Growth of Pancreatic Cancer
Researchers examined the efficacy of in vitro and in vivo treatment with the novel pan-histone deacetylase inhibitor belinostat on the growth of human pancreatic ductal adenocarcinoma cells. [BMC Cancer]
Abstract | Full Article

Opposite Roles of LPA₁ and LPA₃ on Cell Motile and Invasive Activities of Pancreatic Cancer Cells
To assess a biological role of lysophosphatidic acid (LPA) receptors on cell migration of pancreatic cancer cells, scientists generated LPA receptor-1 (LPA₁) and LPA₃ knockdown cells from hamster pancreatic cancer cells by transfection with short hairpin RNA plasmids and measured their cell motile and invasive abilities. [Tumor Biol] Abstract

Cancer Immunotherapy Firm Raises $1.5 Million, Eyes Strategic Partners
A company developing products to restore the immune system of cancer patients has raised $1.5 million and is now looking for strategic partners. IRX Therapeutics’ lead product aims to correct dendritic cell and T-cell defects in cancer patients in order to overcome cancer-induced immune suppression and restore antitumor response. [MEDCITY News] Press Release

TeSR™-E8™ and STEMdiff™: New Products to Advance Research on Human Pluripotent Stem Cells
STEMCELL Technologies Inc. announced its plans to release a series of new products to advance research and translational applications for human pluripotent stem cells. [STEMCELL Technologies Inc.]
Press Release

BGI, GE Healthcare Team Up on Pioneering Stem Cell Science Projects
General Electric (GE) Healthcare and BGI jointly announced a pioneering multi-year research collaboration in stem cell science. [BGI] Press Release

National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting (FR Doc No: 2012-13847) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Fellow – Department of Bioengineering and Barbara Davis Center (University of Colorado at Denver)

Postdoctoral Position – Molecular Endocrinology (Karolinska Institute)

Postdoctoral Research Position for Minority Candidate (New York Obesity Research Center)

Clinical Coordinator (New York Obesity Nutrition Research Center)


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