Volume 3.22 | Jun 5

Pancreatic Cell News 3.22 June 5, 2012
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
Down-Regulation of GEP100 Causes Increase in E-Cadherin Levels and Inhibits Pancreatic Cancer Cell Invasion
Investigators aimed to elucidate the role of GEP100 in pancreatic cancer cell invasion and metastasis and the corresponding molecular mechanism. [PLoS One] Full Article

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PUBLICATIONS (Ranked by impact factor of the journal)

DIABETES

C/EBP Homologous Protein Contributes to Cytokine-Induced Pro-Inflammatory Responses and Apoptosis in ß-Cells
Data suggest that the C/EBP homologous protein (CHOP) has a dual role in promoting ß-cell death: CHOP directly contributes to cytokine-induced ß-cell apoptosis by promoting cytokine-induced mitochondrial pathways of apoptosis; and by supporting the NF-κB activation and subsequent cytokine/chemokine expression, CHOP may contribute to apoptosis and the chemo attraction of mononuclear cells to the islets during insulitis. [Cell Death Differ] Abstract

MSC Anti-Diabetic Effect Is Unrelated to Their Trans-Differentiation Potential but to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment
In type 1 diabetes mellitus (T1DM) animal models, it has been shown that the systemic administration of multipotent mesenchymal stromal cells (MSCs) results in the regeneration of pancreatic islets. Researchers assessed whether donor MSCs differentiate into pancreatic beta-cells and modify systemic and pancreatic pathophysiologic markers of T1DM. [Stem Cells] Abstract

Deletion of p47phox Attenuates the Progression of Diabetic Nephropathy and Reduces the Severity of Diabetes in the Akita Mouse
Researchers concluded that deletion of p47 phox attenuates diabetes-induced glomerular injury and beta cell dysfunction in the Akita mouse. [Diabetologia] Abstract

Mitochondrial Oxidative Stress Contributes Differently to Rat Pancreatic Islet Cell Apoptosis and Insulin Secretory Defects after Prolonged Culture in a Low Non-Stimulating Glucose Concentration
Pancreatic beta cells chronically exposed to low glucose concentrations show signs of oxidative stress, loss of glucose-stimulated insulin secretion (GSIS) and increased apoptosis. Researchers aimed to confirm the role of mitochondrial oxidative stress in rat islet cell apoptosis under these culture conditions and to evaluate whether its reduction similarly improves survival and GSIS. [Diabetologia] Abstract

PANCREATIC CANCER

Nonlinear Optical Microscopy for Histology of Fresh Normal and Cancerous Pancreatic Tissues
In order to investigate whether the nonlinear optical imaging methods have the ability to characterize pancreatic histology at cellular resolution, researchers studied different types of pancreatic tissues by using label-free two-photon excited fluorescence and second harmonic generation. [PLoS One] Full Article

Selective Induction of Apoptosis and Autophagy through Treatment with Dandelion Root Extract in Human Pancreatic Cancer Cells
The authors evaluated the efficacy of dandelion root extract in inducing apoptosis and autophagy in aggressive and resistant pancreatic cancer cells. [Pancreas] Abstract

Reevaluation and Identification of the Best Immunohistochemical Panel (pVHL, Maspin, S100P, IMP-3) for Ductal Adenocarcinoma of the Pancreas
Researchers investigated the utility of 26 immunohistochemical markers in the diagnosis of ductal adenocarcinoma of the pancreas. [Arch Pathol Lab Med] Full Article

Serum Inter-Cellular Adhesion Molecule 1 Is an Early Marker of Diagnosis and Prediction of Severe Acute Pancreatitis
Investigators aimed to determine if serum inter-cellular adhesion molecule 1 is an early marker of the diagnosis and prediction of severe acute pancreatitis within 24 hours of onset of pain, and to compare the sensitivity, specificity and prognostic value of this test with those of acute physiology and chronic health evaluation II score and interleukin-6. [World J Gastroenterol] Full Article

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SCIENCE NEWS

NewLink Genetics Reports Two- and Three-Year Overall Survival Data from Its Phase-II HyperAcute® Pancreas (algenpantucel-L) Immunotherapy Trial
NewLink Genetics Corporation announced that its HyperAcute® Pancreas (Algenpantucel-L) Immunotherapy will be featured in a poster presentation. The study results show 37%, 59% and 121% improvement in one-, two- and three-year survival, respectively, as compared to standard-of-care. [Press release from NewLink Genetics Corporation discussing research presented at the American Society of Clinical Oncology (ASCO) 2012 Annual Meeting, Chicago] Press Release

CytRx Announces Favorable Results from Phase Ib/II Clinical Trial with INNO-206
CytRx Corporation announced favorable clinical results from its Phase Ib/II clinical trial with its tumor-targeting doxorubicin conjugate INNO-206 in patients with advanced solid tumors, primarily soft tissue sarcomas. [Press release from CytRx Corporation discussing research to be presented at the American Society of Clinical Oncology (ASCO) 2012 Annual Meeting, Chicago] Press Release

INDUSTRY NEWS

Bristol-Myers Squibb Announces Global Collaboration with Leading Academic Institutions to Advance Science of Immuno-Oncology
Bristol-Myers Squibb Company announced the formation of the International Immuno-Oncology Network, a global collaboration between industry and academia that aims to further the scientific understanding of immuno-oncology. [Bristol-Myers Squibb Company] Press Release

Columbia’s Cancer Center Receives $40 Million from Herbert & Florence Irving
Herbert and Florence Irving, Columbia University Medical Center’s leading benefactors, have given an additional $40 million to support Columbia’s Herbert Irving Comprehensive Cancer Center. [Columbia University Medical Center] Press Release

POLICY NEWS

White House Petitioned to Make Research Free to Access
More than 17,000 people have signed an online petition urging US President Barack Obama to require all scientific journal articles resulting from US taxpayer-funded research to be made freely available online. [White House, United States] Press Release

Horizon 2020: A €80 Billion Battlefield for Open Access
As negotiations proceed to shape the next installment of Europe’s gargantuan research funding programs, scientists, librarians, and publishers are eagerly awaiting the answer to a critical question: How strong will the new seven-year program, called Horizon 2020, be on Open Access? [European Commission, European Union] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 2012 American Society for Cell Biology (ASCB) Annual Meeting
December 15-19, 2012
San Francisco, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Stem Cell Biology and Regenerative Medicine (Oklahoma Medical Research Foundation)

Postdoctoral Fellow – Department of Bioengineering and Barbara Davis Center (University of Colorado at Denver)

Postdoctoral Position – Molecular Endocrinology (Karolinska Institute)

Postdoctoral Research Position for Minority Candidate (New York Obesity Research Center)


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