Volume 3.15 | Apr 17

Pancreatic Cell News 3.15, April 17, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs 
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TOP STORY
In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking
To investigate the essential physiological role of focal adhesion kinase (FAK) in pancreatic β-cells in vivo, researchers generated a transgenic mouse model using rat insulin promoter-driven Cre-loxP recombination system to specifically delete FAK in pancreatic β-cells. [Diabetes] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Serine/Threonine Protein Phosphatase 5 Regulates Glucose Homeostasis In Vivo and Apoptosis Signaling in Mouse Pancreatic Islets and Clonal MIN6 Cells
Researchers tested the hypothesis that serine/threonine protein phosphatase 5 acts to suppress proapoptotic c-Jun N-terminal kinase signaling in beta cells. [Diabetologia] Abstract

Delta Cell Secretory Responses to Insulin Secretagogues Are Not Mediated Indirectly by Insulin
Scientists investigated whether delta cell secretory responses are indirectly regulated in a paracrine manner by insulin released from beta cells. [Diabetologia] Abstract

Mechanism of Prostacyclin-Induced Potentiation of Glucose-Induced Insulin Secretion
Researchers aimed to analyze the role of prostacyclin in β-cell function. [Endocrinology] Abstract

Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells
Researchers studied the potential effects of STX on pancreatic β-cell function. [PLoS One] Abstract

PANCREATIC CANCER

Comparing Human Pancreatic Cell Secretomes by In Vitro Aptamer Selection Identifies Cyclophilin B as a Candidate Pancreatic Cancer Biomarker
The authors devised an in vitro positive/negative selection strategy to identify RNA ligands that could detect structural differences between the secretomes of pancreatic cancer and non-cancerous cells. [J Clin Invest] Abstract

Molecular Profiling of Pancreatic Neuroendocrine Tumors in Sporadic and Von Hippel-Lindau Patients
Researchers aimed to characterize, by molecular quantitative analysis, a panel of molecules implicated in the Von Hippel-Lindau (VHL) pathway and in tumor progression in the pancreatic neuroendocrine tumors of patients with VHL. [Clin Cancer Res] Abstract

Perifosine-Mediated Akt Inhibition in Neuroendocrine Tumor Cells – Role of Specific Akt Isoforms
Scientists examined the effect of Akt inhibition on neuroendocrine tumor cells of heterogeneous origin. [Endocr Relat Cancer] Abstract

Delivery of Interferon Alpha Using a Novel Cox2-Controlled Adenovirus for Pancreatic Cancer Therapy
Researchers designed a novel targeted adenovirus with replication restricted to cyclooxygenase 2 (Cox2)-overexpressing pancreatic ductal adenocarcinomas and hypothesize that the locally delivered therapeutic gene interferon alpha can augment oncolytic effects while minimizing systemic toxicity. [Surgery] Abstract

The Bisphosphonate Incadronate Inhibits Intraperitoneal Dissemination in an In Vivo Pancreatic Cancer Model
Scientists evaluated the ability of an aminobisphosphonate, incadronate, to inhibit the growth of disseminated pancreatic cancer in vivo. [Oncol Rep] Abstract

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INDUSTRY NEWS

Islet Sciences Announces Receipt of $2.1 Million in Grant Support of Technology
Islet Sciences, Inc. announced that its wholly-owned subsidiary DiaKine Therapeutics, Inc. has received grant support totaling approximately $2.1 million. [Islet Sciences, Inc.] Press Release

American Diabetes Association to Collaborate with Quintiles’ Digital Patient Unit
Quintiles and the American Diabetes Association (Association) announced a strategic agreement in which Quintiles’ Digital Patient Unit will provide the Association’s millions of website users access to Quintiles’ medication monitoring service. [Quintiles] Press Release

NewLink Genetics Receives Notice of Allowance from the Japan Patent Office for New Patent Broadly Covering Its HyperAcute(R) Cancer Immunotherapy Products
NewLink Genetics Corporation announced that the Japan Patent Office has issued a notice of allowance for a patent entitled “Antitumor Vaccination Using Allogeneic Tumor Cells Expressing Alpha (1,3)-Galactosyltransferase,” which contains broad pharmaceutical composition claims covering NewLink’s HyperAcute products for the treatment of cancer. [NewLink Genetics Corporation] Press Release

POLICY NEWS

Pilot and Feasibility Clinical Research Grants in Diabetes, and Endocrine and Metabolic Diseases (R21) (PA-12-157) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW International Society for Stem Cell Research (ISSCR) 10th Annual Meeting
June 13-16, 2012
Yokohama, Japan

Visit
our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Postdoctoral Fellow – Diabetes Genetics Department (INSERM)

Postdoctoral Fellow – Stem Cell Biology (City of Hope Beckman Research Institute)

Director of The Diabetes and Metabolic Disease Research Program (The Methodist Hospital Research Institute)


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