Volume 3.13 | Apr 3

Pancreatic Cell News 3.13, April 3, 2012
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
Redifferentiation of Expanded Human Pancreatic Beta-Cell-Derived Cells by Inhibition of the NOTCH Pathway
Using a β-cell-specific labeling system researchers have shown that β-cell expansion is accompanied by dedifferentiation resembling epithelial-mesenchymal transition, and loss of insulin expression. [J Biol Chem] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Transgenerational Glucose Intolerance with Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
In both first-generation and second-generation offspring of gestational diabetes mellitus mice, the expression of imprinted genes Igf2 and H19 was downregulated in pancreatic islets, caused by abnormal methylation status of the differentially methylated region, which may be one of the mechanisms for impaired islet ultrastructure and function. [Diabetes] Abstract

Control of Beta Cell Function and Proliferation in Mice Stimulated by Small-Molecule Glucokinase Activator under Various Conditions
Researchers investigated changes in the expression of genes involved in beta cell function and proliferation in mouse islets stimulated with glucokinase activator (GKA) in order to elucidate the mechanisms by which GKA stimulates beta cell function and proliferation. [Diabetologia] Abstract

The Transcriptional Co-Repressor Grg3/Tle3 Promotes Pancreatic Endocrine Progenitor Delamination and β-Cell Differentiation
Investigators find that Grg3 normally suppresses E-cadherin gene expression, thereby allowing delamination of endocrine cells from the trunk epithelium and revealing how this transcriptional co-repressor modulates this crucial step of β-cell development. [Development] Abstract

Novel Pancreatic Beta Cell-Specific Proteins: Antibody-Based Proteomics for Identification of New Biomarker Candidates
By antibody-based proteomics, scientists have identified and explored a set of islet cell-specific proteins. [J Proteomics] Abstract

Improving Cellular Function and Immune Protection via Layer-by-Layer Nanocoating of Pancreatic Islet β-Cell Spheroids Cocultured with Mesenchymal Stem Cells
This study aimed to develop a novel strategy to create microenvironment for islets via integration of nanoencapsulation with cell cocultures, thereby enhancing their survival and function. [J Biomed Mater Res A] Abstract

In Vitro Reprogramming of Rat Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells by Genetically Manipulating Negative and Positive Regulators
Investigators determined whether bone marrow-derived mesenchymal stem cells can be directly reprogrammed to islet lineages by simultaneously forced suppression and over-expression of key regulator genes that play critical roles during pancreas development. [Biochem Biophys Res Commun] Abstract

PANCREATIC CANCER

Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma
This preclinical study suggests that anti-epithelial cell adhesion molecule (EpCAM) antibody conjugates with α-amanitin have the potential to be highly effective therapeutic agents for pancreatic carcinomas and various EpCAM-expressing malignancies. [J Natl Cancer Inst] Abstract | Press Release

Hyaluronan Impairs Vascular Function and Drug Delivery in a Mouse Model of Pancreatic Cancer
Researchers examined the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan, as a novel therapeutic target in pancreatic ductal adenocarcinoma. [Gut] Abstract

Pancreatic Stellate Cells Form a Niche for Cancer Stem Cells and Promote Their Self-Renewal and Invasiveness
Researchers demonstrate mechanistically that Nodal-expressing pancreatic stellate cells are an important component of the tumor stroma for creating a paracrine niche for pancreatic cancer stem cells. [Cell Cycle] Abstract

Senescence Determines the Fate of Activated Rat Pancreatic Stellate Cells
Researchers have analyzed senescence as a novel mechanism involved in the termination of pancreatic stellate cell activation and tissue repair. [J Cell Mol Med] Abstract

MicroRNA Expression Aids the Preoperative Diagnosis of Pancreatic Ductal Adenocarcinoma
This study aimed to evaluate microRNA (miRNA) expression in pancreatic resection specimens and fine needle aspiration biopsies and determine which, if any, miRNAs aid the distinction between benign and malignant pancreatic tumors in limited cytology material. [Pancreas] Abstract

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SCIENCE NEWS
Nutritional Supplement Works Against Some Pancreatic Cancer Cells in Mice
The dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice, researchers have found. [Press release from the Mayo Clinic discussing research presented at the American Association for Cancer Research (AACR) Annual Meeting 2012, Chicago] Press Release
INDUSTRY NEWS

NGM and Daiichi Sankyo Collaborate to Discover and Develop Innovative Therapeutics for Diabetes
Daiichi Sankyo Company, Ltd. and NGM Biopharmaceuticals, Inc. announced that they have entered into a research collaboration and license agreement to discover and develop novel therapeutics that modulate beta‐cell regeneration for the treatment of diabetes. [NGM Biopharmaceuticals, Inc.] Press Release

iCo Therapeutics and JDRF Team Up to Support Phase II Clinical Trial iDEAL for Diabetic Macular Edema
iCo Therapeutics and JDRF have joined forces to investigate a potential new treatment for one of the most common complications of diabetes, diabetic macular edema. [iCo Therapeutics, Inc.] Press Release

Einstein Researcher to Receive Top Award from American Federation for Medical Research
Meredith Hawkins, M.D. will receive the American Federation for Medical Research’s highest honor for medical research, the Outstanding Investigator Award. Dr. Hawkins was selected for her diabetes research. [Albert Einstein College of Medicine] Press Release

CPRIT Gives $1 Million to Health Science Center Researchers
The University of Texas (UT) Health Science Center was awarded $1 million by the Cancer Prevention and Research Institute of Texas (CPRIT) to fund instrumentation that will help researchers develop new cancer-fighting drugs. [UT Health Science Center] Press Release

Writing the Book of Cancer Knowledge
An academic-industry collaboration is releasing the first results from a new and freely available resource, the Cancer Cell Line Encyclopedia, that marries deeply detailed cancer genome data with predictors of drug response, information that could lead to refinements in cancer clinical trials and future treatments. [The Eli and Edythe L. Broad Institute] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW European Association for Cancer Research (EACR)-22: From Basic Research to Personalized Cancer Treatment
July 7-10, 2012
Barcelona, Spain

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Postdoctoral Fellow – Diabetes Genetics Department (INSERM)

Postdoctoral Fellow – Stem Cell Biology (City of Hope Beckman Research Institute)

Postdoctoral Research Assistant (Queen Mary, University of London)

Director of The Diabetes and Metabolic Disease Research Program (The Methodist Hospital Research Institute)


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