Volume 3.10 | Mar 13

Pancreatic Cell News 3.10, March 13, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs 
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TOP STORY
Carbohydrate Response Element-Binding Protein (ChREBP) Plays a Pivotal Role in Beta Cell Glucotoxicity
Scientists assessed the role of ChREBP in glucotoxicity in 832/13 beta cells, isolated mouse islets and human pancreas tissue sections using multiple complementary approaches under control and high-glucose-challenge conditions as well as in adeno-associated virus-induced beta cell-specific overexpression of Chrebp (also known as Mlxipl) in mice. [Diabetologia] Abstract

Attend our next hPSC Training Course April 13 - 14, 2012 - Vancouver, Canada
PUBLICATIONS (Ranked by Impact Factor of the Journal)
DIABETES

HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
In this study, scientists demonstrate that HDLs protect β-cells against endoplasmic reticulum (ER) stress induced by thapsigargin, cyclopiazonic acid, palmitate, insulin overexpression, and high glucose concentrations. [Diabetes] Abstract

Glucose-Induced Beta Cell Dysfunction In Vivo in Rats: Link Between Oxidative Stress and Endoplasmic Reticulum Stress
The objective of this study was to determine the causal role of endoplasmic reticulum stress and its link to oxidative stress in glucose-induced beta cell dysfunction in vivo. [Diabetologia] Abstract

Translational Control of Glucose-Induced Islet Amyloid Polypeptide Production in Pancreatic Islets
Here, it was found that acute exposure to high glucose concentrations coordinately regulated the biosynthesis of pro-islet amyloid polypeptide, proinsulin, and its proprotein convertase PC1/3 in normal isolated rat islets, without affecting their respective mRNA levels. [Endocrinology] Abstract

GLP-1-Derived Nonapeptide GLP-1(28-36)Amide Protects Pancreatic Beta Cells from Gluco-Lipotoxicity
Here scientists report that a nonapeptide, GLP-1(28-36)amide, derived from the C-terminal domain of the insulinotropic GLP-1, exerts cytoprotective actions on INS-1 beta cells and on dispersed human islet cells in vitro in conditions of glucolipotoxicity and increased oxidative stress independently of the GLP-1 receptor. [J Endocrinol] Abstract

Agaricus bisporus Lectins Mediates Islet β-Cell Proliferation through Regulation of Cell Cycle Proteins
This study was designed to determine the therapeutic effect of Agaricus bisporus lectins (ABL) by the regeneration of β-cells in mice following 70% partial pancreatectomy, and to explore the mechanisms of ABL-induced β-cell proliferation. [Exp Biol Med] Abstract

PANCREATIC CANCER

Structure-Dependent Activation of NR4A2 (Nurr1) by 1,1-Bis(3′-Indolyl)-1-(Aromatic)Methane Analogs in Pancreatic Cancer Cells
Structure-dependent activation of NR4A2 by a series of 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs was determined in pancreatic cancer cells transfected with yeast GAL4-Nurr1 chimeras and a UASx5-luc reporter gene or constructs containing response elements that bind NR4A2. [Biochem Pharmacol] Abstract

Down-Regulation of Yes Associated Protein 1 Expression Reduces Cell Proliferation and Clonogenicity of Pancreatic Cancer Cells
Immunohistochemical staining of Yes Associated Protein 1 (YAP1) protein was used to assess the expression of YAP1 in pancreatic tumor tissues. siRNA oligonucleotides were used to knockdown the expression of YAP1 and their effects on pancreatic cancer cells were investigated using cell proliferation, apoptosis, and anchorage-independent growth assays. [PLoS One] Abstract

Effects of S-Propargyl-Cysteine in Caerulein-Induced Acute Pancreatitis in Mice
The present study was aimed to investigate the effects of S-propargyl-cysteine in an in vivo model of acute pancreatitis in mice. [PLoS One] Abstract

MicroRNA-10a Is Overexpressed in Human Pancreatic Cancer and Involved in its Invasiveness Partially via Suppression of the HOXA1 Gene
In the present study, the expression levels of specific microRNAs identified by microarray analyses were examined in a panel of 15 pancreatic cancer cell lines. [Ann Surg Oncol] Abstract

Tricellulin Expression in Normal and Neoplastic Human Pancreas
In the present study, researchers have analyzed the expression of tricellulin in normal human pancreas, and in primary exocrine and endocrine pancreatic tumors. [Histopathology] Abstract

Regulation of Pancreatic Cancer Growth by Superoxide
K-ras mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in the molecular pathogenesis. Investigators hypothesized that K-ras oncogene correlates with increased non-mitochondrial-generated superoxide, which could be involved in regulating cell growth contributing to tumor progression. [Mol Carcinog] Abstract

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INDUSTRY NEWS
Orgenesis Inc. Announces Definitive Agreement to Acquire Autologous Insulin Producing Cells Regeneration Technology
Orgenesis Inc. announced that pursuant to a licensing agreement dated February 2, 2012 with Tel Hashomer – Medical Research, Infrastructure and Services Ltd. (THM), the Company has an exclusive license to develop and commercialize THM’s rights in functional AIPC regeneration technology. [Reuters] Press Release

Medistem Signs Exclusive Worldwide License with Yale University for Treatment of Type 1 Diabetes Using Stem Cells
Medistem Inc. and Yale University have signed an exclusive worldwide licensing agreement covering the generation of pancreatic islets from stem cells such as the Endometrial Regenerative Cell. These pancreatic islets have effectively treated diabetes in animal models. [Medistem Inc.] Press Release

Koch Institute, Dana-Farber/Harvard Cancer Center Announce Launch of ‘Bridge Project’ to Attack Most-Lethal Forms of Cancer
The David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology and Dana-Farber/Harvard Cancer Center announced that they have funded several research teams in a joint collaboration aimed at solving the most intractable challenges in cancer. [Massachusetts Institute of Technology News] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
>NEW Centre for Regenerative Medicine: Driving Stem Cell Research Towards Therapy
May 21-22, 2012
Edinburgh, United Kingdom

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Research Assistant (Queen Mary, University of London)

Director of The Diabetes and Metabolic Disease Research Program (The Methodist Hospital Research Institute)


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