Volume 3.07 | Feb 21

Pancreatic Cell News 3.07, February 21, 2012
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
Adenosine Kinase Inhibition Selectively Promotes Rodent and Porcine Islet β-Cell Replication
Here, scientists present the development of a small-molecule screening platform for the identification of molecules that increase β-cell replication. [Proc Natl Acad Sci USA] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)
DIABETES

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Here, researchers integrated type 1 diabetes genome-wide association studies data with protein-protein interactions to construct biological networks of relevance for disease. To prioritize and substantiate the networks, they also performed expressional profiling in human pancreatic islets exposed to proinflammatory cytokines. [Diabetes] Abstract

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca2+ Ions in Pancreatic β-Cells
Here investigators reveal, using both MIN6 and primary mouse β-cells, a unique mechanism behind carbohydrate-responsive element-binding protein (ChREBP) nuclear translocation. [Diabetes] Abstract

Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18
In order to test whether free fatty acids restrict β-cell proliferation in vivo, mice were intravenously infused with saline, Liposyn II, glucose, or both, continuously for 4 days. [Diabetes] Abstract

Islet Amyloid Polypeptide Triggers Limited Complement Activation and Binds Complement Inhibitor C4b-Binding Protein, which Enhances Fibril Formation
Aggregation and formation of islet amyloid polypeptide (IAPP)-amyloid plays a critical role in β-cell death in type 2 diabetic patients. Researchers investigated specific interactions between IAPP and complement factors. [J Biol Chem] Abstract

Comparative Impact on Islet Isolation and Transplant Outcome of the Preservation Solutions Institut Georges Lopez-1, University of Wisconsin, and Celsior
In this study, researchers assessed the impact of Institut Georges Lopez-1, University of Wisconsin, and Celsior solutions on islet isolation and transplant outcome. [Transplantation] Abstract

PANCREATIC CANCER

The Human GLP-1 Analog Liraglutide and the Pancreas: Evidence for the Absence of Structural Pancreatic Changes in Three Species
Scientists investigated whether liraglutide, the once-daily human glucagon-like peptide-1 (GLP-1) analog, induces pancreatitis in rats, mice, and monkeys. [Diabetes] Abstract

Phase I Study of Rigosertib, an Inhibitor of the Phosphatidylinositol 3-Kinase and Polo-Like Kinase 1 Pathways, Combined with Gemcitabine in Patients with Solid Tumors and Pancreatic Cancer
This phase I study aimed to determine the recommended phase II dose of the combination of rigosertib and gemcitabine in cancer patients. [Clin Cancer Res] Abstract

Radiation-Inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine
Here, investigators treated melanoma and pancreatic carcinoma in syngeneic mice with ionizing radiation combined with the poly(ADP-ribose) polymerase inhibitor veliparib to inhibit DNA repair and promote accelerated senescence. [Mol Ther] Abstract

Identification of Glycoprotein Markers for Pancreatic Cancer CD24+CD44+ Stem-Like Cells Using Nano LC-MS/MS and Tissue Microarray
Herein, the malignant phenotype of pancreatic cancer stem-like CD24+CD44+ cells was isolated from a human pancreatic carcinoma cell line (PANC-1), and demonstrated 4-fold increased invasion ability compared to CD24CD44+ cells. [J Proteome Res] Abstract

Long-Term Results of Adjuvant Gemcitabine Plus S-1 Chemotherapy After Surgical Resection for Pancreatic Carcinoma
This study evaluated long-term outcomes for patients who received adjuvant gemcitabine plus S-1 chemotherapy after resection for pancreatic carcinoma. [J Surg Oncol] Abstract

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SCIENCE NEWS
Pathfinder Presents Preliminary Data on New Regenerative Approach to Diabetes Treatment
Pathfinder Cell Therapy, Inc. presented preliminary data highlighting the potential of the Company’s unique cell-based therapy for treating diabetes. Richard L. Franklin provided an overview of the Company’s Pathfinder Cell (PC) technology, and presented preclinical evidence demonstrating how treatment with PCs was able to reverse the symptoms of diabetes in two different mouse models. [Press release from Global Newswire discussing research presented at the 7th Annual New York Stem Cell Summit, New York] Press Release
INDUSTRY NEWS
UCL Spinout Company, Abcodia Collaborates with Volition Rx to Advance the Discovery of Blood Based Biomarkers for Cancer
Abcodia announced a collaboration with life sciences company Volition Rx which will advance the development of biomarkers for the early detection of cancer. [UCL Business PLC] Press Release

Jefferson Kimmel Cancer Center Establishes Center to Eliminate Cancer Disparities
In an effort to reduce and eventually eliminate cancer disparities among adults in the Philadelphia region, the Kimmel Cancer Center at Jefferson has established the Center to Eliminate Cancer Disparities. [Jefferson Kimmel Cancer Center] Press Release

Diabetes Research Institute Foundation Takes Lead Role in University of Miami Momentum2 Campaign
Accelerating its longstanding commitment to cure diabetes, the Diabetes Research Institute Foundation is making the lead gift of $100 million to Momentum2: The Breakthrough Campaign for the University of Miami. [Diabetes Research Institute Foundation] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW ECI Cell Culture Engineering XIII
April 22-27, 2012
Scottsdale, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientific Marketing Communications Specialist (STEMCELL Technologies Inc.)

Research Technologist (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Associate Professor – Stem Cell Biology and Diabetes (McEwen Centre for Regenerative Medicine)

PhD Scholarships – Ion Transport Proteins in Control of Cancer Cell Behavior (Copenhagen University, Faculty of Science)

PhD Student Positions – Stem Cell Differentiation and Cellular Reprogramming (University Hospital of Ulm)


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