Volume 3.00 | Jan 3

Pancreatic Cell News 3.00, January 3, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs 
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TOP STORY
Regulated and Reversible Induction of Adult Human ß-Cell Replication
Researchers attempted to mimic normal, transient, perinatal human ß-cell proliferation by delivering cell cycle molecules in a regulated and reversible manner. [Diabetes] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

L-Leucine Alters Pancreatic ß-Cell Differentiation and Function via the Mammalian Target of Rapamycin Signaling Pathway
Researchers used rat embryonic pancreatic explant culture for elucidating the mechanism of leucine action on ß-cell development. [Diabetes]
Abstract

Multivesicular Exocytosis in Rat Pancreatic Beta Cells
Researchers’ aims were to establish the occurrence, modulation and functional significance of compound exocytosis in insulin-secreting beta cells. [Diabetologia] Abstract

Group VIA PLA2 (iPLA2β) Is Activated Upstream of p38 MAP Kinase in Pancreatic Islet Beta Cell Signaling
Researchers found that p38 MAP Kinase is activated by phosphorylation in INS-1 insulinoma cells and mouse pancreatic islets, that this increases with iPLA2β expression level, and that it is stimulated by the iPLA2β reaction product arachidonic acid. [J Biol Chem] Abstract

FTY720 Normalizes Hyperglycemia by Stimulating β-Cell In Vivo Regeneration in db/db Mice through the Regulation of Cyclin D3 and p57KIP2
Here investigators show that oral administration of FTY720, a sphingosine 1-phosphate receptor modulator, to db/db mice normalizes fasting blood glucose by increasing β-cell mass and blood insulin levels without affecting insulin sensitivity. [J Biol Chem] Abstract

Conophylline Suppresses Pancreatic Stellate Cells and Improves Islet Fibrosis in Goto-Kakizaki Rats
Researchers analyzed the involvement of stellate cells in islet fibrosis in Goto-Kakizaki rats, a model of type 2 diabetes mellitus. [Endocrinology] Abstract

PANCREATIC CANCER

Inhibition of Glycogen Synthase Kinase-3 Activity Triggers an Apoptotic Response in Pancreatic Cancer Cells through JNK-Dependent Mechanism
Researchers demonstrate that prolonged inhibition of glycogen synthase kinase-3 triggers an apoptotic response only in human pancreatic cancer cells but not in human non-transformed pancreatic epithelial cells. [Carcinogenesis] Abstract

Dual Combination Therapy Targeting DR5 and EMMPRIN in Pancreatic Adenocarcinoma
The goal of this study was to assess the efficacy of combined EMMPRIN and DR5 targeted therapy for pancreatic adenocarcinoma in orthotopic mouse models using multi-modal imaging. [Mol Cancer Ther] Abstract

MicroRNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer
Researchers studied the role of mitogen-activated protein kinase in the aberrant expression of microRNAs in pancreatic cancer cells. [Mol Cancer Res] Abstract

Pancreatic Cancer Cells and Normal Pancreatic Duct Epithelial Cells Express an Autocrine Catecholamine Loop That Is Activated by Nicotinic Acetylcholine Receptors α3, α5, and α7
Using two pancreatic cancer cell lines and immortalized pancreatic duct epithelia in vitro, researchers’ current data show, that all three cell lines synthesized and released the catecholamine neurotransmitters noradrenaline and adrenaline upon exposure to nicotine and that this activity was regulated by α3, α5, and α7-nicotinic acetylcholine receptors. [Mol Cancer Res] Abstract

VEGF-A/VEGFR-2 Signaling Plays an Important Role for the Motility of Pancreas Cancer Cells
VEGFRs (vascular endothelial growth factor receptors) might play an important role for the development of pancreatic cancer cells. The purpose of this study was to evaluate the efficacy of VEGF/VEGFR-2-targeted therapy in pancreatic carcinoma. [Ann Surg Oncol] Abstract

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INDUSTRY NEWS

Osiris Therapeutics Provides Update on Groundbreaking Stem Cell Trial for Type 1 Diabetes
Osiris Therapeutics, Inc. provided an update on its Phase II trial evaluating Prochymal, a formulation of adult mesenchymal stem cells, in patients with newly diagnosed type 1 diabetes. [Osiris Therapeutics, Inc.]
Press Release

John Buse to Chair Federal Diabetes Education Program
John Buse, M.D., Ph.D. has been named the new chair of the National Diabetes Education Program. [National Institutes of Health, United States] Press Release

Cellular-Imaging Center Gets Over $8 Million to Speed Search for Earlier Diagnostic Tests and Treatments for Cancer
A team of cancer imaging experts has embarked on a five-year research initiative to speed development of early diagnostic tests and new treatments for breast, prostate and other common cancers. [Johns Hopkins Medicine] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Pathogenesis of Diabetes
January 29-February 3, 2012
Santa Fe, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Fellowship in Stem Cell Biology (The University of British Columbia)

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