Volume 2.41 | Oct 18

Pancreatic Cell News 2.41, October 18, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs 
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TOP STORY
New Molecular Target for Diabetes Treatment Discovered
Researchers have identified a key molecular pathway responsible for the natural decrease in the proliferation of insulin-producing cells that occurs as a person ages. [Press release from the Stanford University School of Medicine discussing online prepublication in Nature] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
The aim of the study was to investigate the effect of WldS (Wallerian degeneration slow) on β-cells and glucose homeostasis. [Diabetes] Abstract

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
The aim of the study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking β-cell ATP-binding cassette transporter A1 (ABCA1). [Diabetes] Abstract

Surface Modification of Pancreatic Islets Using Heparin-DOPA Conjugate and Anti-CD154 mAb for the Prolonged Survival of Intrahepatic Transplanted Islets in a Xenograft Model
The study proposes a combination method of using 3,4-dihydroxy-L-phenylalanine (DOPA) conjugated heparin (heparin-DOPA) and a low dose of anti-CD154 monoclonal antibody (mAb) treatment to improve the survival time of intrahepatic islet xenograft. [Biomaterials] Abstract

Abnormalities of Dendritic Cell Precursors in the Pancreas of the NOD Mouse Model of Diabetes
Here researchers investigated whether the pancreas contains dendritic cell (DC) precursors and whether these precursors contribute to DC accumulation in the non-obese diabetic (NOD) pancreas. [Eur J Immunol] Abstract

Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells
The objective of the study was to investigate the effects of chronic over supply of palmitate upon glucose- and amino acid-stimulated insulin secretion and autocrine-dependent insulin signalling with particular focus on the importance of ceramide, ERK and CaMKII signalling. [PLoS One] Abstract

PANCREATIC CANCER

Variations of Oral Microbiota Are Associated with Pancreatic Diseases Including Pancreatic Cancer
In this study, researchers measured variations of salivary microbiota and evaluated their potential associations with pancreatic cancer and chronic pancreatitis. [Gut] Abstract | Press Release

The Clinical Implications and Biologic Relevance of Neurofilament Expression in Gastroenteropancreatic Neuroendocrine Neoplasms
Given the role of internexin alpha in neuronal development, the authors assessed its function in neuroendocrine cell systems and the clinical implications of its expression as a gastroenteropancreatic neuroendocrine neoplasm biomarker. [Cancer] Abstract

Real-Time Detection of Hepatic Micrometastases from Pancreatic Cancer by Intraoperative Fluorescence Imaging
Recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. [Cancer] Abstract

Differentially Expressed MicroRNAs in Pancreatic Cancer Stem Cells
The objective of the study was to analyze and identify pancreatic cancer stem cell-specific microRNAs and messenger RNAs to investigate their correlations to cancer stem cell biology. [Pancreas] Abstract

Contribution of Germline Mutations in the BRCA and PALB2 Genes to Pancreatic Cancer in Italy
Researchers selected 29 Italian pancreatic adenocarcinoma (PC) patients from a case–control study of PC according to their personal and family history of both PC and breast/ovarian cancer and tested them for presence of germline mutations in BRCA1, BRCA2 and PALB2. [Fam Cancer] Abstract

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INDUSTRY NEWS

Maryland Stem Cell Research Commission Issues Requests for Applications
Per the Maryland Stem Cell Commission (Commission) meeting on Sept.15, 2010, the Commission has issued three official Requests for Applications for funding through the Maryland Stem Cell Research Fund under the Maryland Stem Cell Research Act. [Maryland Stem Cell Research Fund] Press Release

$4.2 Million Grant Funds Type 1 Diabetes Research
A scientist has been awarded $4.2 million from the National Institutes of Health in a program to advance what the agency calls “bold and creative research” into Type I diabetes. [The Scripps Research Institute] Press Release

Infinity Completes Enrollment in Phase 2 Trial of IPI-926, an Oral Smoothened Antagonist, in Pancreatic Cancer and Provides Additional Program Updates
Infinity Pharmaceuticals, Inc. announced updates to its development program for IPI-926, including that the company has completed enrollment of its Phase 2 trial of IPI-926 in patients with previously untreated pancreatic cancer. [Infinity Pharmaceuticals, Inc.] Press Release

POLICY NEWS

Function of Type 1 Diabetes Genes (DP3) (RFA-DK-11-019) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW National Conference on Biopharmaceuticals & Healthcare
November 4-5, 2011
Bangalore, India

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Senior Scientific Advisor for Clinical & Translational Research (The National Institute of Diabetes and Digestive and Kidney Diseases)

Postdoctoral Fellowship in Pancreatic Cancer Research (Johns Hopkins University)

Postdoctoral Fellow – Islet Cell Electrophysiology (Vanderbilt University)    

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