Volume 2.33 | Aug 23

Pancreatic Cell News 2.33, August 23, 2011
     In this issue: Current Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Cellular Features of Senescence During the Evolution of Human and Murine Ductal Pancreatic Cancer
Here, researchers have characterized a panel of potential oncogene-induced senescence biomarkers in human and murine pancreatic intraepithelial neoplasia, and found that only senescence-associated β-galactosidase activity is specifically enriched in these precursors, compared with pancreatic ductal adenocarcinoma. [Oncogene]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Increased Neuronal Nitric Oxide Synthase Dimerisation Is Involved in Rat and Human Pancreatic Beta Cell Hyperactivity in Obesity
The aim was to investigate whether changes in neuronal nitric oxide synthase function affect beta cell compensation in two relevant models: the Zucker fa/fa rats and pancreatic islets from obese humans. [Diabetologia]

A Role for Glutamate Transporters in the Regulation of Insulin Secretion
The data suggests that insulin secretion from β-cells is modulated by the flux of glutamate through the secretory granules. [PLoS One]

Nkx2.2 and Arx Genetically Interact to Regulate Pancreatic Endocrine Cell Development and Endocrine Hormone Expression
To begin to understand the cooperative functions of Nkx2.2 and Arx in the development of endocrine cell lineages, scientists generated progenitor cell-specific deletions of Arx on the Nkx2.2 null background. [Dev Biol]

Activin, BMP and FGF Pathways Cooperate to Promote Endoderm and Pancreatic Lineage Cell Differentiation from Human Embryonic Stem Cells
In this study, investigators describe the roles of growth factors bFGF, BMP4 and Activin A in early human embryonic stem cell fate determination. [Mech Dev]

PANCREATIC CANCER

Proteomic Analysis of an Immortalized Mouse Pancreatic Stellate Cell Line Identifies Differentially-Expressed Proteins in Activated vs. Non-Proliferating Cell States
Researchers aimed to compare differentially expressed proteins from an immortalized cell line of mouse pancreatic stellate cells in the activated and serum-starved cell states using mass spectrometry-based proteomics. [J Proteome Res]

Claudin-4 Expression Predicts Survival in Pancreatic Ductal Adenocarcinoma
Using quantitative real-time reverse transcription-polymerase chain reaction, researchers analyzed CLDN4 mRNA expression in a panel of 9 pancreatic cancer cell lines and formalin-fixed paraffin-embedded tissues from 100 patients with pancreatic ductal adenocarcinoma. [Ann Surg Oncol]

An Oncolytic Adenovirus Defective in pRb-Binding (dl922–947) Can Efficiently Eliminate Pancreatic Cancer Cells and Tumors In Vivo in Combination with 5-FU or Gemcitabine
Researchers demonstrate that dl922–947 is highly efficacious in pancreatic cancers and conclude that oncolytic adenoviruses harboring the E1ACR2 deletion have great potential for development into future clinical candidates for pancreatic cancer. [Cancer Gene Ther]

Over-Expression of FoxM1 Leads to Epithelial–Mesenchymal Transition and Cancer Stem Cell Phenotype in Pancreatic Cancer Cells
Researchers established FoxM1 over-expressing pancreatic cancer (AsPC-1) cells, which showed increased cell growth, clonogenicity, and cell migration. [J Cell Biochem]

Pluripotency-Associated Stem Cell Marker Expression in Proliferative Cell Cultures Derived from Adult Human Pancreas
The aim of this study was to investigate expression of pluripotency-associated stem cell markers in proliferative cultures derived from adult human pancreas. [J Endocrinol]

Transcriptional Activity of DNMT3B in Pancreatic Cancer Cells: Effects of −149 (C → T) Promoter Polymorphism
The aim of this study was to investigate the effect of DNMT3B promoter genetic variant on its transcriptional activity and to compare activity in several pancreatic cell lines. [Biochem Biophys Res Commun]

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INDUSTRY NEWS

Nuvilex’s SG Austria Affiliate Receives Milestone Payment
Nuvilex, Inc. announced its affiliate, SG Austria, has received a milestone payment from the Economic Development Board of Singapore. [Nuvilex, Inc. Press Release]

$30 Million Gift Creates New Center for Personalized Cancer Care
A $30 million gift from the Commonwealth Foundation for Cancer Research has enabled the Johns Hopkins Kimmel Cancer Center to establish a Center for Personalized Cancer Medicine. [Johns Hopkins Medicine Press Release]

POLICY NEWS

Pilot Studies in Pancreatic Cancer (R21) (PA-11-297) [National Institutes of Health, United States]

Pilot Studies in Pancreatic Cancer (R03) (PA-11-298)
[National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW International Society for Cell Therapy North American Regional Meeting
September 14-16, 2011
Charlottesville, United States

Visit our events page to see a complete list of events in the pancreatic cell community.

JOB OPPORTUNITIES
Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Research and Development Technologist (STEMCELL Technologies) 

Postdoctoral Fellow – Stem Cell, Diabetes (City of Hope, Beckman Research Institute)

Senior Scientific Advisor for Clinical & Translational Research (The National Institute of Diabetes and Digestive and Kidney Diseases)

Postdoctoral Fellow in Cardiovascular/Diabetic Research (Boston University)

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