Volume 2.31 | Aug 9

Pancreatic Cell News 2.31, August 9, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Pancreatic β-Cell Prosurvival Effects of the Incretin Hormones Involve Post-Translational Modification of Kv2.1 Delayed Rectifier Channels
Focusing on Kv2.1, researchers examined whether regulation of voltage-gated potassium (Kv) channels in β-cells contributes to the prosurvival effects of incretins. [Cell Death Differ]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Multipotent Stem/Progenitor Cells in Human Biliary Tree Give Rise to Hepatocytes, Cholangiocytes and Pancreatic Islets
Transplantation into quiescent livers of immunocompromised mice results in functional human hepatocytes and cholangiocytes, whereas if into fat pads of streptozocin-induced diabetic mice, results in functional islets secreting glucose-regulatable human C-peptide. [Hepatology]

Modulation of Pancreatic Islets-Stress Axis by Hypothalamic Releasing Hormones and 11β-Hydroxysteroid Dehydrogenase
Here, researchers demonstrate the expression of messenger RNA for corticotropin-releasing hormone (CRH) and CRH-receptor type 1 (CRHR1) and of protein for CRHR1 in rat and human pancreatic islets and rat insulinoma cells. [Proc Nat Acad Sci USA]

Pancreatic β-Cell Raf-1 Is Required for Glucose Tolerance, Insulin Secretion, and Insulin 2 Transcription
This work provides the first direct evidence that Raf-1 signaling is essential for the regulation of basal insulin transcription and the supply of releasable insulin in vivo. [FASEB J]

Formation of Pancreatic Islets Involves Coordinated Expansion of Small Islets and Fission of Large Interconnected Islet-like Structures
Investigators have carried out a comprehensive analysis of changes of islet size distribution in the intact mouse pancreas from birth to eight months, including mathematical modeling to quantify this dynamic biological process. [Biophys J]

Ultrastructural Analysis, Zinc Transporters, Glucose Transporters and Hormones Expression in New World Primate (Callithrix jacchus) and Human Pancreatic Islets
Ultrastructure, and gene expression of pancreatic islets and the recently described diabetes auto antigenic zinc transporters families in human, new world primates and pig pancreas were studied. [Gen Comp Endocrinol]

PANCREATIC CANCER

Deficiency of the Macrophage Growth Factor CSF-1 Disrupts Pancreatic Neuroendocrine Tumor Development
Researchers show in this study that CD68+ macrophages positively correlate with tumor grade and liver metastasis in human pancreatic neuroendocrine tumors. [Oncogene]

High Expression of Delta-Like Ligand 4 Predicts Poor Prognosis After Curative Resection for Pancreatic Cancer
The aim was to determine whether high Delta-Like Ligand 4 expression is correlated with poor prognosis after curative resection for pancreatic ductal adenocarcinoma. [Ann Surg Oncol]

Tumor-Infiltrating Neutrophils in Pancreatic Neoplasia
In this study, the presence of tumor-infiltrating neutrophils within and/or adjacent to neoplastic cells was investigated in pancreatic neoplasms. [Mod Pathol]

Semaphorin 4D, a Lymphocyte Semaphorin, Enhances Tumor Cell Motility Through Binding its Receptor, PlexinB1, in Pancreatic Cancer
Here, researchers report a new signaling pathway that was found to mediate the enhanced tumor cell motility in pancreatic cancer. [Cancer Sci]

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INDUSTRY NEWS

Amarantus BioSciences and Generex Biotechnology Collaborate on Cell Therapy for Late Stage Diabetes
Amarantus BioSciences and Generex Biotechnology Corporation are making public the details of their intended third joint diabetes research collaboration. [Generex Biotechnology Corporation Press Release]

ViaCyte Announces Executive Management Changes
ViaCyte, Inc. announced changes to its executive management team, including the appointment of Allan Robins, Ph.D., as Acting Chief Executive Officer, and the promotion of Kevin D’Amour, Ph.D., to Chief Scientific Officer. [PR Newswire]

Thomas Jefferson University Receives $1 Million to Study Uncharted 98 Percent of Human Genome and its Role in Diseases
The multidisciplinary team will soon begin studying a particular group of DNA motifs called pyknons. Researchers and physicians will be looking at what function they serve in the context of several types of cancers, platelet aggregation properties, two autoimmune disorders, and type-1 diabetes. [Thomas Jefferson University Hospitals Press Release]

DiaMedica Expands Scientific Advisory Board with the Appointment of John M. Amatruda, M.D.
DiaMedica Inc. announced that John M. Amatruda, M.D. has joined the company’s Scientific Advisory Board, enhancing DiaMedica’s experienced advisory team. [DiaMedica Inc. Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Regenerative Medicine: New Approaches to Healthcare
September 28, 2011
New York, United States

Visit our events page to see a complete list of events in the pancreatic cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Fellow – Stem Cell, Diabetes (City of Hope, Beckman Research Institute)

Senior Scientific Advisor for Clinical & Translational Research (The National Institute of Diabetes and Digestive and Kidney Diseases)

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