Volume 2.28 | Jul 19

Pancreatic Cell News 2.28, July 19, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
The L6 Domain Tetraspanin Tm4sf4 Regulates Endocrine Pancreas Differentiation and Directed Cell Migration
In this study, researchers determined that Tm4sf4 is localized to the ductal epithelial compartment and is prominent in the Ngn3+ islet progenitor cells. [Development]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
DIABETES

Accurate Measurement of Pancreatic Islet ß-cell Mass Using a Second-Generation Fluorescent Exendin-4 Analog
Researchers report on the development and testing of a near-infrared fluorescent ß-cell imaging agent. [Proc Nat Acad Sci USA]

Generation of Pancreatic Insulin-Producing Cells From Rhesus Monkey Induced Pluripotent Stem Cells
Here researchers try to generate insulin-producing cells from rhesus monkey induced pluripotent stem cells. [Diabetologia]

Association Between the GIPR Gene and the Insulin Level After Glucose Loading in Schizophrenia Patients Treated with Olanzapine
Researchers assessed the influence of the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene polymorphism (rs10423928) on glucose metabolism in 60 schizophrenic patients treated with olanzapine and 103 healthy controls. [Pharmacogenomics J]

Apelin Alleviates Diabetes-Associated Endoplasmic Reticulum Stress in the Pancreas of Akita Mice
Researchers aimed to investigate the effects of apelin on endoplasmic reticulum stress in the pancreas of Akita mice, a well-established type 1 diabetic model. [Peptides]

Improved Outcome of Islet Transplantation in Partially Pancreatectomized Diabetic Mice by Inhibition of Dipeptidyl Peptidase-4 with Sitagliptin
This study was designed to evaluate the effects of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on the outcome of islet transplantation in diabetic mice after partial pancreatectomy. [Pancreas]

PANCREATIC CANCER

Oncogene-Induced Nrf2 Transcription Promotes ROS Detoxification and Tumorigenesis
Here, researchers investigated reactive oxygen species (ROS) metabolism in primary murine cells following the expression of endogenous
oncogenic alleles of Kras, Braf and Myc, and found that ROS are actively suppressed by these oncogenes. [Nature]

Advancing a Clinically Relevant Perspective of the Clonal Nature of Cancer
Researchers applied DNA content-based flow sorting to identify and isolate the nuclei of clonal populations from tumor biopsies, which was
coupled with array CGH and targeted resequencing. [Proc Nat Acad Sci USA]

A Dose Escalation Study of Gemcitabine Plus Oxaliplatin in Combination with Imatinib for Gemcitabine-Refractory Advanced Pancreatic Adenocarcinoma
This study aimed to define safe doses of gemcitabine plus oxaliplatin when combined with imatinib in patients with advanced gemcitabine-refractory pancreatic cancer. [Ann Oncol]

Pinhole Micro-SPECT/CT for Noninvasive Monitoring and Quantitation of Oncolytic Virus Dispersion and Percent Infection in Solid Tumors
The purpose of this study was to validate the ability of pinhole micro-single-photon emission computed tomography/computed tomography
(SPECT/CT) to accurately resolve the intratumoral dispersion pattern and quantify the infection percentage in solid tumors of an oncolytic measles virus encoding the human sodium iodide symporter. [Gene Ther]

Comprehensive Genomic Analysis of a BRCA2 Deficient Human Pancreatic Cancer
Here researchers report a genome-wide assessment of structural variations and high-depth exome characterization of single nucleotide
variants and small insertion/deletions in Capan-1. [PLoS One]

Galectin-1 Secreted by Activated Stellate Cells in Pancreatic Ductal Adenocarcinoma Stroma Promotes Proliferation and Invasion of Pancreatic Cancer Cells: An In Vitro Study on the Microenvironment of Pancreatic Ductal Adenocarcinoma
This study aimed to clarify that the activated pancreatic stellate cells are the origin of the highly expressed galectin-1 in the stroma of pancreatic ductal adenocarcinoma tissue and to evaluate the effect of the secreted galectin-1 on proliferation and invasion ability of pancreatic cancer cell line CFPAC-1 in vitro. [Pancreas]

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INDUSTRY NEWS

Novo Nordisk Gains EU Approval for FlexTouch® – The Latest Innovation within Prefilled Insulin Pens
Novo Nordisk has been granted approval by the European Commission for the new prefilled insulin pen – FlexTouch®. [Novo Nordisk A/S Press Release]

Novartis Delivers Strong Financial Results and Four Major Approvals in Second Quarter of 2011
Novartis achieved 19% sales growth in constant currencies and excellent operating leverage in the second quarter. [Novartis International AG Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 2011 World Stem Cell Summit
October 3-5, 2011
Pasadena, United States

Visit
our events page to see a complete list of events in the pancreatic cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Post-Doctoral Research Fellow (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Stem Cell Biology and Immunology (NIH Center for Biomedical Research Excellence)

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