Volume 2.13 | Apr 5

Pancreatic Cell News 2.13, April 5, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Cell-Cell Communication Mimicry with Poly(Ethylene Glycol) Hydrogels for Enhancing β-Cell Function
The biomimetic hydrogels presented here can provide crucial cell-cell communication signals for dispersed β-cells and improve their survival and proliferation. [Proc Natl Acad Sci U S A]

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SCIENCE NEWS

Diabetes Veterans May Show Ways to Prevent Complications
A major study has found that some people who have survived diabetes for many decades exhibit remarkably few complications—a discovery that points toward the presence of protective factors that guard against the disease’s effects. [Press release from Joslin Diabetes Center discussing online prepublication in Diabetes Care]

Aspirin May Lower the Risk of Pancreatic Cancer
The use of aspirin at least once per month is associated with a significant decrease in pancreatic cancer risk, according to results of a large case-control study. [Press release from the American Association for Cancer Research (AACR) discussing research presented at the AACR 102nd Annual Meeting 2011]

Avoiding or Controlling Diabetes May Reduce Cancer Risk and Mortality
Results of the National Institutes of Health-American Association of Retired Persons Diet and Health Study revealed that diabetes is associated with lower risk of prostate cancer in men but with higher risk of other cancers in both men and women. [Press release from the American Association for Cancer Research (AACR) discussing research presented at the AACR 102nd Annual Meeting 2011]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Viral Infection Prevents Diabetes by Inducing Regulatory T Cells Through NKT Cell-Plasmacytoid Dendritic Cell Interplay
As invariant natural killer T (NKT) cell-plasmacytoid dendritic cell cooperation controls viral replication in the pancreatic islets, researchers investigated whether this cellular cross talk could interfere with type 1 diabetes development during viral infection. [J Exp Med]

Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts
The objective of this study was to determine whether somatic fibroblasts from NOD mice could be reprogrammed to become induced pluripotent stem cells, providing an alternative source of stem cells for the production of genetically modified NOD cells and mice. [Diabetes]

Immobilization of Soluble Complement Receptor 1 on Islets
Human soluble complement receptor 1 was immobilized on the islet cell surface through poly(ethylene glycol)-conjugated phospholipid without loss of islet cell viability or insulin secretion ability. [Biomaterials]

Protection from Retinopathy and Other Complications in Patients with Type 1 Diabetes of Extreme Duration
Researchers assessed complication prevalence and identify protective factors in patients with diabetes duration of more of 50 years. [Diabetes Care]

Glucagon-Like Peptide 1 Stimulates Post-Translational Activation of Glucokinase in Pancreatic Beta Cells
Researchers report that glucagon-like peptide 1 augments glucose-dependent rises in NAD(P)H autofluorescence in both βTC3 insulinoma cells and islets in a manner consistent with post-translational activation of glucokinase. [J Biol Chem]

Differences Between Human and Rodent Pancreatic Islets: Low Pyruvate Carboxylase, ATP Citrate Lyase and Pyruvate Carboxylation; High Glucose-Stimulated Acetoacetate in Human Pancreatic Islets
The present information supports previous data that indicate beta cells can use a pathway involving succinyl-CoA:3-ketoacid-CoA transferase and acetoacetyl-CoA synthetase to synthesize and use acetoacetate and suggests human islets may use this pathway more than pyruvate carboxylase and citrate to form cytosolic acyl-CoAs. [J Biol Chem]

Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice Via an Inhibition of Insulin Secretion
Overexpression of human IGF binding protein-3 in mice delays in vivo insulin clearance and reduces glucose-stimulated insulin secretion in pancreatic islets by both IGF-dependent and IGF-independent mechanisms. [Endocrinology]

PANCREATIC CANCER

Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy
Researchers define three pancreatic ductal adenocarcinoma subtypes: classical, quasimesenchymal and exocrine-like, and present evidence for clinical outcome and therapeutic response differences between them. [Nat Med]

Trefoil Factor 1 Acts to Suppress Senescence Induced by Oncogene Activation During the Cellular Transformation Process
Researchers report that trefoil factor 1 acts as a promoter of tumorigenesis in the context of prostate and pancreatic cancers by suppressing oncogene-induced senescence. [Proc Natl Acad Sci U S A]

Role of Heparanase in Radiation-Enhanced Invasiveness of Pancreatic Carcinoma
Results suggest that combining radiotherapy with heparanase inhibition is an effective strategy to prevent tumor resistance and dissemination, observed in many ionizing radiation-treated pancreatic cancer patients. [Cancer Res]

Silencing of hHS6ST2 Inhibits Progression of Pancreatic Cancer Through Inhibition of Notch Signaling
Researchers found that hHS6ST2, not other virants, was activated in human pancreatic cancer. [Biochem J]

Protein Alterations Associated with Pancreatic Cancer and Chronic Pancreatitis Found in Human Plasma Using Global Quantitative Proteomics Profiling
Differential proteins associated with pancreatic cancer were identified, and their relationship with the proteome of pancreatic tissue and pancreatic juice from our previous studies was discussed. [J Proteome Res]

INDUSTRY NEWS

Tethys and Duke Clinical Research Institute Establish PREVAIL Initiative to Improve Care and Reduce Incidence of Type 2 Diabetes
Tethys Bioscience, Inc. and Duke Clinical Research Institute have established the PREVAIL patient registry, a multi-center, national initiative that will analyze primary care ambulatory practices for risk factor management of patients at high risk of conversion to type 2 diabetes in the U.S. [Tethys Bioscience, Inc. Press Release]

Abcodia Builds Interanational Collaborations to Support Earlier Diagnosis of Pancreatic Cancer
Abcodia, a newly formed company engaged in the validation and discovery of molecular biomarkers for disease diagnosis and screening, is seeking to advance the screening and diagnosis of pancreatic cancer and help save countless lives through the use of its human serum collected from over 202,000 volunteers. [Cambridge Network Press Release]

Sirona Biochem Acquires TFChem
Sirona Biochem Corporation announced that it has completed its acquisition of TFChem S.A.S. [Sirona Biochem Corporation Press Release]

American Diabetes Association Announces New Research Grant Program in Clinical Care Delivery
A major new research initiative was announced by the American Diabetes Association. The awards are part of a $1.5 million initiative being funded by sanofi-aventis U.S. [American Diabetes Association Press Release]

CPRIT Awards $36.7 Million to UT Southwestern Investigators for Cancer Studies
The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded more than $36.7 million in new grants to investigators at UT Southwestern Medical Center to support cancer-related projects and to recruit pre-eminent cancer investigators. [University of Texas Southwestern Medical Center Press Release]

Neogenix Oncology Novel Therapeutic Antibody, NEO-101 (Ensituximab) Data to Be Presented at AACR’s 2011 Annual Symposium
Neogenix Oncology, Inc. announced that members of its scientific staff will present laboratory studies of NEO-101, a novel monoclonal antibody in development to diagnose and treat pancreatic and colorectal cancers. [BusinessWire]

Metabolic Solutions Development Company Launches Phase IIa Trial of Its Second Compound to Treat Type 2 Diabetes
Metabolic Solutions Development Company (MSDC) announced that it has launched a Phase IIa trial for MSDC-0602, the company’s second drug candidate for the treatment of type 2 diabetes. [Metabolic Solutions Development Company Press Release]

Infinity to Present New Preclinical Data on IPI-926, a Novel Smoothened Antagonist Targeting the Hedgehog Pathway, at Upcoming AACR Meeting
Infinity Pharmaceuticals, Inc. announced that the company will present new preclinical data supporting ongoing development of IPI-926 in chondrosarcoma during the American Association for Cancer Research 102nd Annual Meeting. IPI-926 is a novel, oral molecule that inhibits Smoothened, a key component of the Hedgehog pathway. [Infinity Pharmaceuticals, Inc. Press Release]

Report to Nation Finds Continued Declines in Many Cancer Rates
Rates of death in the United States from all cancers for men and women continued to decline between 2003 and 2007, the most recent reporting period available, according to the latest Annual Report to the Nation on the Status of Cancer. [National Institutes of Health Press Release]

POLICY NEWS
Next Set of NICE Quality Standards Launched on Depression, Diabetes and Glaucoma
NICE has launched new quality standards on depression in adults, diabetes in adults and glaucoma, adding to the library of standards already published. [National Institute for Health and Clinical Excellence, United Kingdom]

New Strategic Plan for NIH Obesity Research Seeks to Curb Epidemic
To combat the obesity epidemic, the National Institutes of Health is encouraging diverse scientific investigations through a new Strategic Plan for NIH Obesity Research. [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW 2011 American Society of Clinical Oncology Annual Meeting
June 3-7, 2011
Chicago, United States

NEW The Endocrine Society’s 93rd Annual Meeting & Expo (ENDO 2011)
June 4-7, 2011
Boston, United States

NEW American Diabetes Association’s 71st Scientific Sessions
June 24-28, 2011
San Diego, United States

Visit our events page to see a complete list of events in the pancreatic cell community.

JOB OPPORTUNITIES

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Position (Johns Hopkins University School of Medicine)

Postdoctoral Positions – Stem Cell Biology (Joslin Diabetes Center/Harvard Stem Cell Institute)

Field Applications Specialist – Cell Therapy (Medical) (Pall Corporation)

Postdoctoral Scientist (University of Oxford Nuffield Department of Surgical Sciences)

Postdoctoral Research Fellowship in Diabetes/Cardiovascular Disease (Children’s Hospital Boston/Harvard Medical School)

Postdoctoral Research Fellow in Bioinformatics/Computational Biology – Diabetes (Lund University)

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