Volume 2.04 | Feb 1

Pancreatic Cell News 2.04, February 1, 2011.

TOP STORY 

Researchers Uncover Potential ‘Cure’ for Type 1 Diabetes  ShareThis
Type 1 diabetes could be converted to an asymptomatic, non-insulin-dependent disorder by eliminating the actions of a specific hormone, new findings suggest. These findings in mice show that insulin becomes completely superfluous and its absence does not cause diabetes or any other abnormality when the actions of glucagon are suppressed. [Press release from University of Texas Southwestern Medical Center discussing online prepublication in Diabetes]
 
ON134_645x110
 
SPECIAL FEATURES
 


Facebook Cell Therapy News is now on Facebook. Join us!

Twitter Follow us on Twitter! @PancreaticCell

Interested in recruiting talented individuals? Post your career opportunities in Pancreatic Cell News at no cost. Contact us at [email protected]

SCIENCE NEWS

Artificial Pancreas in Pregnancy Promises Fewer Diabetes Deaths
Research has for the first time successfully demonstrated the potential of an artificial pancreas in pregnant women with type 1 diabetes. [Press release from the University of Cambridge discussing online prepublication in Diabetes Care]

Immunomedics Reports First Experimental Studies Combining Antibody-Drug Conjugate with Antibody-Directed Radiation Therapy for Pancreatic Cancer
Immunomedics, Inc. announced that combining antibody-directed drug and radionuclide therapeutics for pancreatic cancer improved efficacy in preclinical studies with minimal toxicity. [Press release from Immunomedics, Inc. discussing research presented at the American Society of Clinical Oncology 2011 Gastrointestinal Cancers Symposium]

ON122-mTeSR1_SC_645x110

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Magnetosome-Like Ferrimagnetic Iron Oxide Nanocubes for Highly Sensitive MRI of Single Cells and Transplanted Pancreatic Islets
Pancreatic islet grafts and their rejection could be imaged using ferrimagnetic iron oxide nanocubes (FIONs) on a 1.5 T clinical magnetic resonance imaging (MRI) scanner. The strong contrast effect of FIONs enabled MR imaging of transplanted islets in small rodents as well as in large animals. [ Proc Natl Acad Sci U S A]

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
Researchers conclude that blocking glucagon action prevents the deadly metabolic and clinical derangements of type 1 diabetic mice. [Diabetes]

Ongoing Beta Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes
Researchers aimed 1) to measure beta cell turnover in adult nonhuman primates; 2) to establish the relative contribution of beta cell replication and formation of new beta cells from other precursors; and 3) to establish whether there is an adaptive increase in beta cell formation in streptozotocin-induced diabetes in adult nonhuman primates. [Diabetes]

The Expression and Function of Glucose-Dependent Insulinotropic Polypeptide in the Embryonic Mouse Pancreas
Glucose-dependent insulinotropic polypeptide signaling may play a role in early embryonic pancreas differentiation to form insulin-positive cells or beta cells. [Diabetes]

Phosphatidylinositol-4-Phosphate-5-Kinase Alpha Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice
Findings suggest that phosphatidylinositol-4-phosphate-5-kinase alpha plays a complex role in restricting insulin release from pancreatic beta cells through helping to maintain plasma membrane phosphatidylinositol-4,5-bisphosphate levels and integrity of the actin cytoskeleton under both basal and stimulatory conditions. [Diabetes]

Stage-Specific Signaling Through TGF Beta Family Members and WNT Regulates Patterning and Pancreatic Specification of Human Pluripotent Stem Cells
Researchers elucidated the temporal requirements for TGF beta family members and canonical WNT signaling at these developmental stages and show that the duration of nodal/activin A signaling plays a pivotal role in establishing an appropriate definitive endoderm population for specification to the pancreatic lineage. [Development]

Sox9+ Ductal Cells Are Multipotent Progenitors Throughout Development But Do Not Produce New Endocrine Cells in the Normal or Injured Adult Pancreas
Although endocrine cells arise from the Sox9+ ductal domain throughout embryogenesis and the early postnatal period, Sox9+ ductal cells of the adult pancreas no longer give rise to endocrine cells under both normal conditions and in response to partial duct ligation. [ Development]

Closed-Loop Insulin Delivery During Pregnancy Complicated by Type 1 Diabetes
This study evaluated closed-loop insulin delivery with a model predictive control algorithm during early (12-16 weeks) and late gestation (28-32 weeks) in pregnant women with type 1 diabetes. [Diabetes Care]

Co-Transplantation of Mesenchymal Stem Cells Maintains Islet Organization and Morphology in Mice
Co-transplantation of islets with mesenchymal stem cells (MSCs) had a profound impact on the remodeling process, maintaining islet organization and improving islet revascularization. MSCs also improved the capacity of islets to reverse hyperglycemia. [Diabetologia]

PANCREATIC CANCER

Spatial Regulation of RhoA Activity During Pancreatic Cancer Cell Invasion Driven by Mutant p53
Researchers demonstrate for the first time, an analysis of RhoA activity at a subcellular level using FLIM-FRET (fluorescence lifetime imaging microscopy-fluorescence resonance energy transfer) imaging in a live animal model of pancreatic cancer. [Cancer Res]

Intracellular CD24 Inhibits Cell Invasion by Posttranscriptional Regulation of BART Through Interaction with G3BP
Researchers report a novel function for the CD24 molecule in pancreatic cancer cells. Results imply that surface CD24 may play a role in the inhibition of cell invasion and metastasis, and that intracellular CD24 inhibits invasiveness and metastasis through its influence on the posttranscriptional regulation of Binder of Arl Two (BART) mRNA levels via G3BP RNase activity. [Cancer Res]

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth
Results provide evidence that combined targeted biological therapy in addition to cytotoxic chemotherapy can overcome treatment resistance. Such treatment strategies may be used to tailor therapy based on identified biomarkers of resistance to targeted monotherapy. [Clin Cancer Res]

INDUSTRY NEWS

Six Million Euros for Europe Wide Diabetes Research Network
The Peninsula College of Medicine and Dentistry, University of Exeter, is one of 13 academic institutions and businesses across Europe to form a EUR 6 million research and analysis network, funded by the EU for a five-year period, which is designed to investigate the possible role of virus infection in the cause of type 1 diabetes. [Peninsula College of Medicine and Dentistry Press Release]

Diamyd Expects to Begin Reporting Phase III Results in Late Spring 2011
Diamyd Medical’s President and CEO Elisabeth Lindner states in the CEO comments in a quarterly report that the Company expects to begin reporting the results from the European Phase III trial in type 1 diabetes as planned in late spring 2011. [Diamyd Medical AB Press Release]

Ecron Acunova Adds on Stem Cell Therapy and Diabetes Center to Conduct Studies for Global and Indian Sponsors
Ecron Acunova, a full-fledged clinical research organization, has added an additional focus area which is the stem cell therapy and diabetes centre. The center provides the marketing authorization for allogenic or autologous stem cell products. [PharmaBiz]

Number of Americans with Diabetes Rises to Nearly 26 Million
Nearly 26 million Americans have diabetes, according to new estimates from the Centers for Disease Control and Prevention. In addition, an estimated 79 million U.S. adults have prediabetes, a condition in which blood sugar levels are higher than normal, but not high enough to be diagnosed as diabetes. [Centers for Disease Control and Prevention Press Release]

American Diabetes Association Announces 2010 Diabetes Year-in-Review
The American Diabetes Association released its diabetes year-in-review for 2010. The complete list, which highlights focusing on diabetes achievements by the numbers, can be found at www.diabetes.org. [American Diabetes Association Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS

NEW PancreasFest 2011
July 28-30, 2011
Pittsburgh, United States

Visit
our events page to see a complete list of events in the pancreatic cell community.


JOB OPPORTUNITIES

Lab Technologist – Cell Separation (STEMCELL Technologies)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Postdoctoral Scientist (University of Oxford Nuffield Department of Surgical Sciences)

Chief, Division of Endocrinology (University of Florida/Shands)

Postdoctoral Research Fellowship in Diabetes/Cardiovascular Disease (Children’s Hospital Boston/Harvard Medical School)

Postdoctoral Research Fellow in Bioinformatics/Computational Biology – Diabetes (Lund University)

Recruit Top Talent

Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News at no cost.

Visit
here to post your career opportunities.



Have we missed an important article or publication in Pancreatic Cell News? Click here to submit!

 
forwardafriendicon

Learn more about Pancreatic Cell News: Archives | Events | Contact Us