Volume 2.01 | Jan 11

Pancreatic Cell News 2.01, January 11, 2011.

TOP STORY 

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes  ShareThis
Researchers identified a common variant (rs950994) in the human transcription factor B1 mitochondrial (TFB1M) gene associated with reduced insulin secretion, elevated postprandial glucose levels, and future risk of type 2 diabetes. [Cell Metab]

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SCIENCE NEWS

Less Invasive Techniques Help Manage Complications of Severe Pancreatic Disease
The use of combined treatments for severe acute pancreatitis is safe and effective in managing the disease, resulting in shorter hospitalizations and fewer radiological procedures than standard therapy, according to a study. [Press release from EurekAlert! discussing online prepublication in Clinical Gastroenterology and Hepatology]

Researchers Take Step Forward in Diabetes Study
Researchers are studying a solution they believe will improve the quantity and quality of isolated human pancreatic islet cells. The harvested cells can then be transplanted into the livers of patients with type 1 diabetes, enabling them to produce their own insulin. [Baylor Health Care System Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Augmented Glucose-Induced Insulin Release in Mice Lacking Go2, but not Go1 or Gi Proteins
Researchers show that one of the two splice variants of Go, Go2, is a key player in the control of glucose-induced insulin secretion by beta cells. [Proc Natl Acad Sci U S A]
 
Genetic Inducible Fate Mapping in Larval Zebrafish Reveals Origins of Adult Insulin-Producing Beta Cells
Researchers report on using Cre-based fate mapping to indelibly label pancreatic Notch-responsive cells (PNCs) at larval stages and follow their fate in the adult pancreas. They show that the PNCs represent a population of progenitors that can differentiate to multiple lineages, including adult ductal cells, centroacinar cells and endocrine cells. [Development ]

Glucagon-Like Peptide-1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in Humans
The glucagon-like peptide receptor agonist exenatide prevented prednisolone-induced glucose intolerance and islet-cell dysfunction in healthy humans. Incretin-based therapies should be explored as a potential strategy to prevent steroid diabetes. [Diabetes Care]

Paracrine Signaling Loops in Adult Human and Mouse Pancreatic Islets: Netrins Modulate Beta Cell Apoptosis Signaling via Dependence Receptors
Results highlight the large number of potential islet growth factors and point to a context-dependent pro-survival role for netrins in adult beta cells. [Diabetologia]

An Islet-Specific Pulse of TGF-Beta Abrogates CTL Function and Promotes Beta Cell Survival Independent of Foxp3+ T Cells
Researchers show that expression of TGF-beta for just 1 week in inflamed islets of non-obese diabetic mice significantly delays diabetes development. [J Immunol]

Differential Regulation of Endoplasmic Reticulum Stress by Protein Tyrosine Phosphatase 1B and T Cell Protein Tyrosine Phosphatase
Results demonstrate that protein-tyrosine phosphatase 1B (PTP1B) and T cell protein-tyrosine phosphatase (TCPTP) play non-redundant roles in modulating endoplasmic reticulum (ER) stress in pancreatic beta cells and suggest that changes in PTP1B and TCPTP expression may serve as an adaptive response for the mitigation of chronic ER stress. [J Biol Chem]

Metabolomic Analyses Reveal Profound Differences in Glycolytic and Tricarboxylic Acid Cycle Metabolism in Glucose-Responsive and -Unresponsive Clonal Beta Cell Lines
To increase understanding of stimulus-secretion coupling and metabolic processes potentially involved in the pathogenesis of type 2 diabetes, a comprehensive investigation of the metabolic response in the glucose-responsive INS-1 832/13 and glucose-unresponsive INS-1 832/2 beta cell lines was performed. [Biochem J]

PANCREATIC CANCER

miR-301a as an NF-KappaB Activator in Pancreatic Cancer Cells
In this work, researchers investigated whether microRNAs contribute to NF-kappaB activation in pancreatic cancer. [EMBO J]

Lineage Tracing Reveals the Dynamic Contribution of Hes1+ Cells to the Developing and Adult Pancreas
The study clarifies the roles of Notch and Hes1 in the developing and adult pancreas, and open new avenues to study Notch signaling in this and other tissues. [Development]

DNA Mismatch Repair Gene Polymorphisms Affect Survival in Pancreatic Cancer
DNA mismatch repair gene variants may have potential value as prognostic markers for overall survival in pancreatic cancer patients. [Oncologist]

Endoscopic and Percutaneous Drainage of Symptomatic Walled-Off Pancreatic Necrosis Reduces Hospital Stay and Radiographic Resources
For patients with symptomatic walled-off pancreatic necrosis, combined modality therapy provided a more effective and safer management technique, resulting in shorter hospitalizations and fewer radiologic procedures than standard percutaneous drainage. [Clin Gastroenterol Hepatol]

Glutamate Increases Pancreatic Cancer Cell Invasion and Migration via AMPA Receptor Activation and Kras-MAPK Signaling
Researchers show that glutamate-mediated alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activation increases invasion and migration of pancreatic cancer cells via activation of the classical MAPK pathway. [Int J Cancer]

INDUSTRY NEWS

Boehringer Ingelheim and Eli Lilly and Company Announce Strategic Alliance to Bring New Diabetes Treatments to Patients Worldwide
Boehringer Ingelheim and Eli Lilly and Company announced a global agreement to jointly develop and commercialize a portfolio of diabetes compounds currently in mid- and late-stage development. [Boehringer Ingelheim GmbH Press Release]

Neogenix Oncology® Receives Additional Federal Grant, Bringing Total Award to Over $730,000
Neogenix Oncology, Inc. announced that the company has been awarded an additional grant under the Qualifying Therapeutic Discovery Project Program, bringing the total amount received by Neogenix Oncology under this federal program to $733,437.74. [Business Wire]

Merck Announces FDA Acceptance of New Drug Application for an Investigational Extended-Release Formulation of JANUMET® (sitagliptin/metformin HCI) for Type 2 Diabetes
Merck announced that the New Drug Application for the Company’s investigational extended-release formulation of JANUMET for type 2 diabetes has been accepted for standard review by the U.S. Food and Drug Administration (FDA). [Merck & Co., Inc. Press Release]

DARA BioSciences Announces Additional Details From Phase I Clinical Study of DB959 for the Treatment of Type 2 Diabetes
DARA BioSciences, Inc. provided additional details from the recently completed Phase I clinical study for DB959, its PPAR (peroxisome proliferator activated receptor) delta/gamma agonist, an oral drug in development for the treatment of type 2 diabetes. [DARA BioSciences, Inc. Press Release]

Lexicon Announces Positive Results from New Clinical Study of LX4211 in Type 2 Diabetes Patients
Lexicon Pharmaceuticals, Inc. announced data from a recently completed clinical trial and mechanistic study of a solid oral dose formulation for LX4211, a dual inhibitor of sodium-glucose co-transporters 1 and 2. [Lexicon Pharmaceuticals, Inc. Press Release]

Peregrine Initiates Randomized Phase II Trial of Bavituximab in Pancreatic Cancer
Peregrine Pharmaceuticals, Inc. announced that it has initiated a randomized Phase II clinical trial in patients with previously untreated stage IV pancreatic cancer. [Peregrine Pharmaceuticals, Inc. Press Release]

American Diabetes Association Announces New National Officers and Board Members
The American Diabetes Association is pleased to announce its officers and Board of Directors members for 2011. [American Diabetes Association Press Release]

POLICY NEWS

The Number of U.S. Adults Treated for Diabetes More Than Doubled Between 1996 and 2007
Approximately 19 million U.S. adults reported receiving treatment for diabetes in 2007, more than double the 9 million who said they received care in 1996, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. [Agency for Healthcare Research and Quality, United States]

American Diabetes Association Announces Legislative Priorities
The American Diabetes Association is pleased to announce its legislative priorities for the first session of the 112th Congress. [American Diabetes Association, United States]

FDA Questions Effectiveness of Proposed Pancreatic-Enzyme Drug
Food and Drug Administration (FDA) staff questioned whether a new type of a pancreatic-enzyme replacement product is as effective as products now on the market. [Food and Drug Administration, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS

NEW 13th World Congress of the International Pancreas and Islet Transplant Association (IPITA)
June 1-4, 2011
Prague, Czech Republic

Visit
our events page to stay up to date with the latest events in the pancreatic cell community.


JOB OPPORTUNITIES

Lab Technologist – Cell Separation (STEMCELL Technologies)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Postdoctoral Scientist (University of Oxford Nuffield Department of Surgical Sciences)

Chief, Division of Endocrinology (University of Florida/Shands)

Principal Investigator, Stem Cell Biology and Diabetes (McEwen Centre for Regenerative Medicine/ University of Toronto)

Postdoctoral Research Fellowship in Diabetes/Cardiovascular Disease (Children’s Hospital Boston/Harvard Medical School)

Postdoctoral Research Associate in Ryanodine Receptor Calcium Signaling and Pancreatitis (Yale University School of Medicine)

Postdoctoral Research Fellow in Bioinformatics/Computational Biology – Diabetes (Lund University)


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