Volume 11.23 | Jun 16

2020-16-06 | PACN 11.23
Pancreatic Cell News by STEMCELL Technologies
Vol. 11.23 – June 16, 2020
TOP STORY

BAP1 Is a Haploinsufficient Tumor Suppressor Linking Chronic Pancreatitis to Pancreatic Cancer in Mice

Researchers found that heterozygous loss of histone H2A lysine 119 deubiquitinase BRCA1 Associated Protein-1 associated with a history of chronic pancreatitis and occurred in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.
[Nature Communications]

Full Article

Explore Antibodies for Epithelial Cell Markers
PUBLICATIONSRanked by the impact factor of the journal

NKG2D Signaling within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T Cell Numbers

To directly assess the role of NKG2D in the pancreas, researchers generated NOD mice that expressed an NKG2D ligand in β-islet cells.
[Diabetes]

Abstract

Fasting Parameters for Estimation of Stimulated β-Cell Function in Islet Transplant Recipients with or without Basal Insulin Treatment

Scientists determined to what extent fasting glycemic indices could estimate stimulated β‐cell function in islet transplant recipients with and without basal insulin.
[American Journal of Transplantation]

Abstract

MicroRNA-181c-5p Promotes the Formation of Insulin-Producing Cells from Human Induced Pluripotent Stem Cells by Targeting smad7 and TGIF2

Investigators showed that the accelerated phenotype was driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Cell Death & Disease]

Full Article

Mutations in the C1 Element of the Insulin Promoter Lead to Diabetic Phenotypes in Homozygous Mice

Scientists used CRISPR–Cas9 technology to generate mice with mutations in the promoter regions of the insulin I and II genes.
[Communications Biology]

Full Article

Plasma Interleukin-8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer

In vivo activity of nanoliposomal irinotecan was validated in an orthotopic nude murine model expressing TAK1-specific shRNA. Differential expression profiling revealed the gene coding for interleukin-8 as the most significantly downregulated in shTAK1 pancreatic cancer cell lines.
[Clinical Cancer Research]

AbstractFull Article

Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways

Researchers showed glutathione S-transferase pi-1 knockdown reduced pancreatic ductal adenocarcinoma (PDAC) cell growth, prolonged the G0/G1 phase, and elevated reactive oxygen species in PDAC cells.
[Cancers]

Full ArticleGraphical Abstract

An Unbiased High‐Throughput Drug Screen Reveals a Potential Therapeutic Vulnerability in the Most Lethal Molecular Subtype of Pancreatic Cancer

In multiple in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC), spanning human and murine PDAC cells, and orthotopic xenografts, researchers determined that the expression of keratin 17 resulted in a more than two‐fold increase in resistance to Gem and 5‐fluorouracil, key components of current standard‐of‐care chemotherapeutic regimens.
[Molecular Oncology]

Abstract

Mir34a Constrains Pancreatic Carcinogenesis

Investigators showed that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Scientific Reports]

Full Article

Download an e-book covering the evolution of organoids, from their development to updated applications and future outlooks.
REVIEWS

Beta-Cell Failure in Type 2 Diabetes: Mechanisms, Markers, and Clinical Implications

Researchers discuss the progression of type 2 diabetes mellitus in the context of beta-cell failure and describe how C-peptide testing can be used to assess beta-cell function in primary care practice.
[Postgraduate Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Seven Bridges and the Pancreatic Cancer Action Network Partner to Develop High-Quality, Actionable Cancer Data Platform

Seven Bridges announced that it has been selected by the Pancreatic Cancer Action Network to build a customized, integrated health data platform to accelerate pancreatic cancer research.
[Seven Bridges Genomics]

Press Release

PharmaCyte Biotech Completes Final cGMP Audit of Manufacturing Facility for Pancreatic Cancer Clinical Trial Product

PharmaCyte Biotech, Inc. announced that cGMP Validation, the company’s cGMP consultant, has completed its post manufacturing audit of the manufacturing facility in Thailand and that the facility has successfully passed the audit.
[PharmaCyte Biotech, Inc.]

Press Release

Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]

Editorial

FEATURED EVENT

International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs

2020-10-12 – 2020-10-14
Paris, France

> See All Events

JOB OPPORTUNITIES

Postdoctoral Fellow in Diabetes, Molecular Metabolism and Cardiovascular Research

Cornell University – New York City, New York, United States

Postdoctoral Scholar – Developmental & Stem Cell Biology

University of California San Francisco – San Francisco, California, United States

PhD Student – Pancreatic Cancer

University College Dublin – Dublin, Ireland

Postdoctoral Scientist Position – Drug Vulnerabilities of Pancreatic Cancer

Klinikum rechts der Isar der Technischen Universität München – Munich, Germany

Senior Investigator – Electron Microscopy Research

NIH National Cancer Institute – Bethesda, Maryland, United States

Postdoctoral Fellow – Pancreas and Islet Biology Research

Vanderbilt University Medical Center – Nashville, Tennessee, United States

Postdoctoral Position – Diabetic Endothelial Cell Remodeling

Aarhus University – Aarhus C, Denmark

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism

The University of Alabama at Birmingham – Birmingham, Alabama, United States

Research Positions – Pancreatic Beta-Cells

Université de Montréal – Montréal, Quebec, Canada

> See All Jobs

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