Volume 1.35 | Dec 21

Pancreatic Cell News 1.35, December 21, 2010.

TOP STORY 

Neurogenin3 Inhibits Proliferation in Endocrine Progenitors by Inducing Cdkn1a  ShareThis
The study reveals a crucial role for Neurogenin3 (Neurog3) in regulating the cell cycle during the differentiation of islet cells and demonstrates that the subsequent down-regulation of Neurog3 allows the mature islet cell population to expand. [Proc Natl Acad Sci U S A]

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SCIENCE NEWS

Missing Molecules Hold Promise of Therapy for Pancreatic Cancer
The production of a particular cluster of genetic snippets known as microRNAs is dramatically reduced in human pancreatic tumor cells compared to healthy tissue. When researchers restored this tiny regulator, called miR-143/145, back to normal levels in human pancreatic cancer cells, those cells lost their ability to form tumors. [Press release from Johns Hopkins Medicine discussing online prepublication in Genes and Development]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Variants and Haplotypes of TCF7L2 Are Associated with Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1
TCF7L2 diabetes risk variants, either as single-nucleotide polymorphisms or as haplotypes, detrimentally influence beta cell function and might play a role in determining the metabolic phenotype of patients with newly diagnosed type 2 diabetes. [J Clin Endocrinol Metab]

Resveratrol Potentiates Glucose-Stimulated Insulin Secretion in INS-1E Beta Cells and Human Islets Through Sirt1 Dependent Mechanism
Resveratrol markedly enhanced the glucose response of INS-1E cells and human islets, even after removal of the compound from the medium. [J Biol Chem]

Structural Polymorphism of Human Islet Amyloid Polypeptide (hIAPP) Oligomers Highlights the Importance of Interfacial Residue Interactions
In this work, on the basis of recent solid-state NMR and mass-per-length data, researchers model a series of human islet amyloid polypeptide oligomers with different beta-layers (one, two, and three layers), symmetries (symmetry and asymmetry), and associated interfaces using molecular dynamics simulations. [Biomacromolecules]

Beta Cell Neogenesis: Experimental Considerations in Adult Stem Cell Differentiation
Using the smallest subset of bone marrow cells lacking immuno-hematopoietic lineage markers, researchers have detected incorporation and conversion into insulin-producing cells. [Stem Cells Dev]

Bone Marrow-Derived Mesenchymal Stem Cells Co-Cultured with Pancreatic Islets Display Beta Cell Plasticity
The direct co-culturing effect of rat bone-marrow-derived mesenchymal stem cells on the pancreatic islets was studied to obtain functional islet cells. [J Tissue Eng Regen Med]

PANCREATIC CANCER

Repression of the miR-143/145 Cluster by Oncogenic Ras Initiates a Tumor-Promoting Feed-Forward Pathway
Loss of miR-143/145 expression is observed frequently in KRAS mutant pancreatic cancers, and restoration of these microRNAs abrogates tumorigenesis. [Genes Dev]

Panhematin Provides a Therapeutic Benefit in Experimental Pancreatitis
Researchers tested the utility of Panhematin, a water-soluble hemin formulation, in activating and inducing pancreatic heme-oxygenase-1, and as a therapeutic agent in treating mouse acute pancreatitis. [Gut]

Role for NQO1 and MnSOD in 17AAG-Induced Hsp90 Inhibition in Pancreatic Cancer Cells
Data confirm the role of NQO1 in sensitivity to 17AAG and demonstrate that superoxide dismutase functions in conjunction with NQO1 to maintain intracellular levels of 17AAGH2, the active Hsp90 inhibitor derived from17AAG. [J Pharmacol Exp The]
 
Overexpression of KAI1 Induces Autophagy and Increases MiaPaCa-2 Cell Survival Through the Phosphorylation of Extracellular Signal-Regulated Kinases
By using transmission electron microscopy, confocal microscopy, and western blotting, researchers found that KAI1 can induce autophagy in a dose- and time-dependent manner in the human pancreatic cell line MiaPaCa-2. [Biochem Biophys Res Commun]

The Neuronal Pentraxin II Gene (NPTX2) Inhibits Proliferation and Invasion of Pancreatic Cancer Cells In Vitro
This study suggests that NPTX2, as a tumor-suppressor, plays an anti-tumor effect on pancreatic cancer and its low expression, due to promoter hypermethylation, may play a role in the tumorigenesis of pancreatic cancer. [Mol Biol Rep]

INDUSTRY NEWS

Metabolic Disease Alliance with MedImmune
Evotec AG announced that via its subsidiary Develogen AG it has entered into a license and collaboration agreement with MedImmune (the global biologics unit of AstraZeneca), in the diabetes therapeutic area, with a particular focus on the regeneration of insulin producing beta cells. [Evotec AG Press Release]

Cancer Research Institute Announces Launch of Cancer Vaccine Acceleration Fund
Cancer Research Institute, Inc. announced the launch of the Cancer Vaccine Acceleration Fund, a new model of philanthropic investment and academic-industry collaboration established in partnership with the Ludwig Institute for Cancer Research Ltd. to speed the clinical development of therapeutic cancer vaccines and other immune system-based therapies. [Cancer Research Institute, Inc. Press Release]

Medtronic Launches CareLink Pro 3.0, the First Diabetes Management Software to Offer Advanced Decision Support
Medtronic, Inc. announced the Food and Drug Administration approval and the market launch of CareLink® Pro 3.0 Therapy Management Software, the first software program to offer advanced decision support to healthcare professionals managing diabetes. [Medtronic, Inc. Press Release]

Myriad Genetics Launches PANEXIA, New Predictive Test for Hereditary Pancreatic and Related Cancers
Myriad Genetics, Inc. announced the launch of PANEXIA™, a predictive medicine product for hereditary pancreatic and related cancers. PANEXIA is a comprehensive analysis of the PALB2 and BRCA2 genes for assessing a person’s risk of developing pancreatic cancer later in life. [Myriad Genetics, Inc. Press Release]

POLICY NEWS

Senate Spending Bill Would Boost NSF, NIH Budgets
In some good fiscal news for the U.S. science community, a Senate spending panel has crafted a 2011 federal budget that would give several science agencies increases that are close to their requested levels. [Senate, United States]

Collaboration Offers Clinical Center Resources to External Investigators
A new pilot partnership between the National Institutes of Health Clinical Center, the National Cancer Institute’s Center for Cancer Research, and the Damon Runyon Cancer Research Foundation will offer some of the capabilities and expertise of America’s research hospital to an external group of clinical investigators in cancer research. [National Institutes of Health, United States]

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS (Listed by Date)

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Keystone Symposia: Obesity
January 12-17, 2011
Keystone, United States

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Early Development for Innovative Diabetes & Metabolic Syndrome Therapeutics Conference
January 26-27, 2011
Amsterdam, The Netherlands

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

2nd Annual International Diabetes Summit
February 22-24, 2011
Dubai, United Arab Emirates

World Cell Culture Congress 2011
February 28-March 2, 2011
Munich, Germany

PITTCON 2011
March 13-18, 2011
Atlanta, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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