Volume 1.33 | Dec 7

Pancreatic Cell News 1.33, December 7, 2010.

TOP STORY 

Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats  ShareThis
Human bone marrow-derived clonal mesenchymal stem cells (hcMSCs) reduced inflammation and damage to pancreatic tissue in a rat model of acute pancreatitis; they reduced levels of cytokines and induced numbers of Foxp3+ regulatory T cells. hcMSCs might be developed as a cell therapy for pancreatitis. [Gastroenterology]

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SCIENCE NEWS

Researchers Identify Why Diabetes Risk Increases as We Age
A new study shows that enhancing activity of a gene in the mitochondria prevents damage that can trigger type 2 diabetes. [Press release from Yale University discussing online prepublication in Cell Metabolism

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance
Data suggest that the preserved mitochondrial function maintained by reducing mitochondrial oxidative damage may prevent age-associated whole-body energy imbalance and muscle insulin resistance. [Cell Metab]
 
Noninvasive Imaging of Pancreatic Islet Inflammation in Type 1A Diabetes Patients
Researchers report the development of a noninvasive method to visualize type 1A diabetes at the target organ level in patients with active insulitis. [J Clin Invest]
 
Calcineurin Increases Glucose Activation of ERK1/2 by Reversing Negative Feedback
Researchers show that, in beta cells, glucose activates the ERK1/2 cascade primarily through B-Raf. [Proc Natl Acad Sci U S A]

Controlled Insulin Release from Glucose-Sensitive Self-Assembled Multilayer Films Based on 21-Arm Star Polymer
A glucose-sensitive multilayer film was fabricated by the layer-by-layer assembly method with positively charged 21-arm poly[2-(dimethylamino)ethyl methacrylate] (star PDMAEMA) and negatively charged insulin and glucose oxidase in the form of {(Star PDMAEMA/Insulin)4 + (Star PDMAEMA/GOD)4 + Star PDMAEMA}. [Biomaterials]

TNF-Alpha Acutely Upregulates Amylin Expression in Murine Pancreatic Beta Cells
TNF-alpha acutely induces amylin gene expression in beta cells through multiple signaling pathways, possibly contributing to amylin elevation in acute inflammation-related pancreatic disorders. [Diabetologia]
 
Decreased Insulin Secretion and Increased Risk of Type 2 Diabetes Associated with Allelic Variations of the WFS1 Gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Prospective Study
The most frequent haplotype at the haplotype block containing the WFS1 gene modulated insulin secretion and was associated with an increased risk of type 2 diabetes. [Diabetologia]
 
Evaluation of Impaired Beta Cell Function in Nonobese-Diabetic (NOD) Mouse Model Using Bioluminescence Imaging
This is the first evidence that selective expression of the luciferase gene represents a sensitive method for noninvasive in vivo monitoring of early beta cell dysfunction, subtle metabolic changes, such as endogenous ATP levels, indicative of a pathological condition in a tissue at the cellular level. [FASEB J]
 
Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic Beta Cells
Researchers show that downregulation of the class II phosphoinositide 3-kinase (PI3K) isoform PI3K-C2alpha specifically impairs insulin granule exocytosis in rat insulinoma cells without affecting insulin content, the number of insulin granules at the plasma membrane or the expression levels of key proteins involved in insulin secretion. [J Biol Chem]

PANCREATIC CANCER


The Receptor for Advanced Glycation End-products (RAGE) Protects Pancreatic Tumor Cells Against Oxidative Injury
Researchers investigated the effect of oxidative stress on activation of the Receptor for Advanced Glycation Endproducts (RAGE) and subsequent protection against H2O2-induced pancreatic tumor cell damage. They found that exposure of pancreatic tumor cells to H2O2 provoked a nuclear factor kappa B-dependent increase in RAGE expression. [Antioxid Redox Signal]
 
NADPH Oxidase Activation in Pancreatic Cancer Cells Is Mediated Through Akt Dependent Up-Regulation of p22phox
Researchers investigate the mechanisms through which insulin-like growth factor I and serum activate NADPH oxidase in pancreatic cancer cells. [J Biol Chem]
 
Melatonin Reduces Pancreatic Tumor Cell Viability by Altering Mitochondrial Physiology
Data support the likelihood that melatonin reduces viability of tumor AR42J cells via its action on mitochondrial activity and caspase-3 activation. [J Pineal Res]

INDUSTRY NEWS

Merck to Acquire SmartCells, Inc.
Merck & Co., Inc. and SmartCells, Inc. announced that they have entered into a definitive agreement under which Merck will acquire SmartCells, a private company developing a glucose responsive insulin formulation for the treatment of diabetes mellitus. [Merck & Co., Inc. Press Release]

Eurand to be Acquired by Axcan for $12.00 per Share in Cash
Eurand N.V. and Axcan Holdings, Inc. announced that they have entered into a definitive agreement under which Axcan will acquire all the outstanding shares of Eurand for $12.00 per share in cash. [Axcan Holdings, Inc. Press Release]

Case Western Reserve University Grants Thermalin Diabetes Exclusive License For Insulin Analog Therapies
Case Western Reserve University has granted an exclusive license on a portfolio of insulin analogs to Thermalin Diabetes, LLC, which has assembled more than $3 million to support the development of these important new drugs. [Case Western Reserve University Press Release]

SUTENT® Receives European Approval for a New Indication in Progressive Pancreatic Neuroendocrine Tumors (NET)
Pfizer Inc. announced that the European Commission has approved SUTENT® (sunitinib malate) for the treatment of unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumors with disease progression in adults. [Pfizer Inc. Press Release]

New International Competition Focuses on Early Career Scientists
The Howard Hughes Medical Institute launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents with the goal of helping these talented individuals establish independent research programs. [Howard Hughes Medical Institute Press Release]

POLICY NEWS

FDA and Life Sciences Industry Relationship Is Complicated by New Science and Changing Expectations, Finds PwC Survey
Growing public demand for increased medical device and drug safety, as well as the need to develop medical products faster, is complicating the current regulatory approval process and relationship between the life sciences industry and its chief regulator, the U.S. Food and Drug Administration, according to a new PricewaterhouseCoopers (PwC) report. [Food and Drug Administration, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)
 
Therapeutic Goods Administration (Australia)

EVENTS (Listed by Date)

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Keystone Symposia: Obesity
January 12-17, 2011
Keystone, United States

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Early Development for Innovative Diabetes & Metabolic Syndrome Therapeutics Conference
January 26-27, 2011
Amsterdam, The Netherlands

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

2nd Annual International Diabetes Summit
February 22-24, 2011
Dubai, United Arab Emirates

World Cell Culture Congress 2011
February 28-March 2, 2011
Munich, Germany

PITTCON 2011
March 13-18, 2011
Atlanta, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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